Sex differences in the association of adverse childhood experiences on past 30-day opioid misuse among Florida justice-involved children.

INTRODUCTION: Opioid misuse remains a chief public health concern in the United States, especially among justice-involved children and adolescents (JIC). Adverse childhood experiences (ACEs) are prevalent among JIC and are associated with a higher risk for opioid misuse. Justice involvement can be harsher for females, who tend to have higher ACE scores and experience more physiological and psychological risk factors than males. However, this study was the first to examine how sex may moderate the link between ACEs and opioid misuse. This study hypothesized that females will have higher odds of opioid misuse than males with equivalent ACEs. METHODS: The study team examined cross-sectional data on 79,960 JIC in the Florida Department of Juvenile Justice from 2007 to 2015. The study measured ACEs using 10 questions from the Positive Achievement Change Tool. Opioid misuse was reported by either self-disclosure, positive urinalysis, or other evidence of opioid consumption within the past 30 days. The team estimated logistic regression, marginal effects, and multiplicative interaction terms to test the hypotheses. RESULTS: JIC with an ACE score of 4 or higher were 2.59 times more likely to misuse opioids than JIC with lower ACE scores. Among JIC with 4 or more ACEs, females had significantly higher odds of opioid misuse than males. CONCLUSION: Reducing exposure to ACEs may decrease the risk for opioid misuse, particularly among females. These findings corroborate trauma-informed and sex-responsive prevention programs in the juvenile justice system.

Sex differences in the effects of physical and sexual abuse on the odds of past 30-day opioid misuse among Florida justice-involved children.

AIM: Opioid misuse is a severe threat to justice-involved children and adolescents. Identifying risk factors and sex differences is critical to design accurate risk assessments and person-centered interventions. Stress theory and research posit that abuse may be linked to opioid misuse, and the consequences may be harsher for females. The study tests the hypothesis that physical and sexual abuse will individually and cumulatively increase the risk for opioid misuse, and females will have a higher risk than males. METHODS: A statewide sample of 79,960 justice-involved children in Florida were examined. Opioid misuse, illicit and non-medical use, was measured by urine analysis or self-disclosure within the past-30 days. Bivariate and multivariate logistic regression analyses were employed. Marginal effects were estimated to investigate the interaction between abuse and sex. RESULTS: Over 2000 youth met the criteria for opioid misuse. One-third of female opioid users experienced both physical and sexual abuse. Compared to those with no history of physical or sexual abuse, those who were physically abused had 43% higher odds of opioid misuse, those who were sexually abuse had 78% higher odds, and those who experienced both had twice as high odds of opioid misuse. The individual and combined effects of these abuse types were higher for females. For example, female youth who were sexually abused had 2.7-times higher odds of opioid misuse than males who were sexually abused. CONCLUSION: Intervention efforts can be improved by integrating physical and sexual abuse into risk assessments and tailoring assessments by sex.