[Basis for the use of enclosed 125I sources for interstitial radiation therapy]. / Obosnovanie primeneniia zakrytykh istochnikov 125I dlia vnutritkanevoi luchevoi terapii.

Experimental models of closed sources of 125I low energy photon radiation in the titanium capsules sealed by means of pulsed laser welding were designed. Doses in the tissue equivalent medium from a single 125I point source were calculated using ES-1022 computer, tables for calculating dose fields in different layouts of sources were drawn, and layout parameters in preset doses calculated. Using the 125I source in interstitial irradiation of murine breast tumors one managed to establish the local nature of tissues corresponding to the calculated dose distribution for photon radiation with the energy of 27-35 keV.

[Experimental evaluation of Bengal rose labeled with 123I]. / Eksperimental'naia otsenka bengal'skogo rozovogo, mechennogo 123I]

Experimental evaluation of Bengal rose labeled with short-lived 123I was performed. The best diagnostic feature in 123I-Bengal rose were shown during a scintigraphic study of the rabbit liver and biliferous tract conducted in simultaneous experiments with the use of the agent labeled with 131I and 99mTc-HIDA. These were a high quality of the image of the organs, a low radiation exposure and the absence of extrahepatic uptake of the agent, particularly under conditions of the ligament of the common bile duct. The absence of a noticeable toxic effect of 123I-Bengal rose was established in experiments on rats and mice.

[Dosimetric characteristics of encapsulated 125I sources for interstitial radiation therapy]. / Dozimetricheskie kharakteristiki kapsulirovannykh istochnikov 125I dlia vnutritkanevoi luchevoi terapii.

Thermoluminescent dosimetry in the Mix-D material was used to study the dosimetric characteristics of discrete sources in the form of titanium and nylon capsules, sizes 0.8 X 2.5 and 1.7 X 7 mm with an activity of 20-40 MB K. Permissible within the limits of volume subject to radiotherapy, dose field parameters and a higher dose gradient beyond the field limits as compared to 226Ra, 198Au and 192Ir were established. Manufactured 125I discrete sources meet the requirements of interstitial radiation therapy in the protracted tumor irradiation mode.

[Radionuclide study of the influence of beta-adrenoblockaders on the cardiotonic effect of cardiac glycosides]. / Radionuklidnoe issledovanie vliianiia beta-adrenoblokatorov na kardiotonicheskii éffekt serdechnykh glikozidov.

Radiocardiography was used in 234 patients to explore the effect of corglycon, a glycoside drug obtained from Convallaria L., cardiac glycoside (CG) digoxin, beta-adrenoblockers (BAB) anapriline and trasicor, and combinations of CG and BAB on the minute and stroke volumes of the circulation and heart rate. It has been shown that administration of CG coupled with BAB increasing the tolerance to the cardiotoxic effect of CG does not entail a reduction of their beneficial inotropic action.