1.
J Inorg Biochem
; 66(2): 77-82, 1997 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9112758
RESUMO
Two novel metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic, and X-ray diffraction methods. The crystal structure of both, (erxH2) [FeCl4]Cl and (kinoH2)[CuCl4]. H2O, is presented and discussed (erxH2 = doubly protonated form of enrofloxacin, kinoH2 = doubly protonated form of the second quinolone). In both compounds, the hydrogen atom is bonded between the 4-keto oxygen O(1) and carboxylic oxygen O(11), thus preventing the bonding of the metal to this part of the molecule. Antimicrobial activities of metal-quinolone compounds were tested against different microorganisms.
Assuntos
Anti-Infecciosos/química , Metais , Quinolonas/química , Antibacterianos , Anti-Infecciosos/síntese química , Anti-Infecciosos/farmacologia , Bactérias/efeitos dos fármacos , Cristalografia por Raios X , Fungos/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Modelos Moleculares , Estrutura Molecular , Quinolonas/síntese química , Quinolonas/farmacologia , Relação Estrutura-Atividade
2.
Boll Chim Farm
; 114(3): 146-50, 1975 Mar.
Artigo
em Italiano
| MEDLINE
| ID: mdl-1131317