1.
Bioorg Med Chem Lett
; 9(13): 1807-12, 1999 Jul 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10406646
RESUMO
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo in the ovariectomized rat model of osteoporosis.