RESUMO
The extent of extrahepatic hepatitis C virus (HCV) replication seems to be low-level and confined to cells of hematopoietic lineage. However, given the spectrum of extrahepatic manifestations associated with HCV, several tissues other than the liver have been suggested as targets of HCV replication and damage. The presence and level of HCV RNA were examined in 19 skin tissue samples from patients chronically infected with HCV and referred for lichen ruber planus (n = 11) or cutaneous vasculitis associated with mixed cryoglobulinemia (n = 8). Serum HCV RNA was quantitated and genotyped by assays that are available commercially. Tissue HCV RNA of genomic- and minus-strand polarity was titrated by a strand-specific semiquantitative RT-PCR. Low titers of genomic-strand HCV RNA were found in three skin specimens from patients with cutaneous vasculitis due to mixed cryoglobulinemia, but in none with lichen ruber planus. The replication intermediate HCV RNA was not detected in any of the skin tissues examined, independent of the serum HCV RNA level or genotype. It is concluded that the occurrence of cutaneous vasculitis and lichen ruber planus in chronic hepatitis C patients is unlikely to be due to HCV replication in the skin.
Assuntos
Hepacivirus/isolamento & purificação , Hepatite C Crônica/virologia , Líquen Plano/virologia , Vasculite Leucocitoclástica Cutânea/virologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Crioglobulinemia/complicações , Feminino , Genótipo , Hepacivirus/fisiologia , Hepatite C Crônica/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , RNA Viral/sangue , RNA Viral/genética , Replicação ViralRESUMO
NERDS is an eosinophilic disorder recently described by Butterfield and characterized by an association of nodules, eosinophilia, rheumatism, dermatitis and swelling. We describe an additional case, the third, of this new eosinophilic syndrome. The cardinal features included joint and cutaneous manifestations with prominent para-articular nodules and rheumatism, xerosis, recurrent urticarial eruption with angioedema associated with tissue and peripheral blood eosinophilia. A drug-induced (diclofenac) allergic rash and lymphadenopathy appeared during the course of the illness. Persistent leukocytosis with a maximum of 65% of eosinophils, mostly exhibiting the hypodense phenotype (activation index), was always present. During the acute phase of the disease, flow-cytometric analysis of blood and bone marrow revealed proliferation of activated CD4+/OKDR+ T helper cells and CD25+/OKDR+ eosinophils.
Assuntos
Dermatite/diagnóstico , Edema/diagnóstico , Eosinofilia/diagnóstico , Doenças Reumáticas/diagnóstico , Nódulo Reumático/diagnóstico , Doença Aguda , Antígenos CD4/metabolismo , Dermatite/imunologia , Edema/imunologia , Eosinofilia/imunologia , Eosinófilos/imunologia , Feminino , Citometria de Fluxo , Antígenos HLA-DR/metabolismo , Humanos , Ativação Linfocitária , Pessoa de Meia-Idade , Receptores de Interleucina-2/metabolismo , Doenças Reumáticas/imunologia , Nódulo Reumático/imunologia , Síndrome , Linfócitos T Auxiliares-Indutores/imunologiaAssuntos
Amálgama Dentário/efeitos adversos , Dermatite Alérgica de Contato/patologia , Doenças da Língua/induzido quimicamente , Idoso , Diagnóstico Diferencial , Feminino , Humanos , Hipertrofia , Língua/efeitos dos fármacos , Língua/patologia , Doenças da Língua/patologia , Neoplasias da Língua/patologiaRESUMO
The authors present a case of Muir-Torre syndrome, the "sporadic" form, with a review of the literature. The importance of the close scrutiny of these patients and their relatives is stressed.
Assuntos
Neoplasias Abdominais , Adenoma , Neoplasias Faciais , Neoplasias Primárias Múltiplas , Neoplasias das Glândulas Sebáceas , Família , Feminino , Humanos , Pessoa de Meia-Idade , Linhagem , SíndromeAssuntos
Matadouros , Dermatite de Contato/etiologia , Dermatite Ocupacional/etiologia , Dermatoses da Mão/etiologia , Carne/efeitos adversos , Adulto , Animais , Bovinos , Humanos , Hipersensibilidade Imediata/imunologia , Masculino , Proteínas/efeitos adversos , Teste de Radioalergoadsorção , Dermatopatias Vesiculobolhosas/etiologiaRESUMO
We describe 2 cases of severe photosensitivity dermatitis following the use of nifedipine for arterial hypertension. In both cases casual rechallenge with nifedipine confirmed that this drug was the causative agent.
Assuntos
Toxidermias/etiologia , Nifedipino/efeitos adversos , Transtornos de Fotossensibilidade/induzido quimicamente , Idoso , Toxidermias/patologia , Feminino , Humanos , Hipertensão/tratamento farmacológico , Pessoa de Meia-Idade , Transtornos de Fotossensibilidade/patologiaRESUMO
A case of early cutaneous involvement by an acute myeloid leukemia in a Caucasian man, previously affected by a "classical" Kaposi's sarcoma is reported. The diagnoses were based upon histologic examinations and appropriate hematologic investigations. After reviewing extensively the literature about the association of lymphoreticular system malignancies and Kaposi's sarcoma, possible implications and hypothetical etiopathogenetic mechanisms are discussed.
Assuntos
Leucemia Mieloide Aguda/patologia , Neoplasias Primárias Múltiplas/patologia , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A case of Lichen aureus in a 15-year old boy is presented. The case is particularly underlined due to lesions on both legs.