[Chlamydia infection in gynecology]. / Chlamydieninfektion in der gynäkologie.

The frequency of chlamydial infections was investigated by means of the McCoy culture technique and a serological procedure using the microimmunofluorescence test in female outpatients showing suspect symptoms; in patients suffering from acute salpingitis, and in women with involuntary infertility. In 18.6% of 290 subjects of the first group, chlamydiae were isolated from cultures. Of 26 patients with acute salpingitis, Chlamydia trachomatis could be detected in 10. The high frequency of positive serological tests suggests chlamydial infection to constitute an important etiological factor in female infertility and extrauterine pregnancies.

[Genital chlamydia infections and extrauterine pregnancy]. / Genitale Chlamydieninfektionen und Extrauteringravidität.

Serum samples of 217 patients with ectopic pregnancy (e.p.) and of 152 women with intrauterine pregnancy (i.u.p.) were examined for their antibody content to chlamydia trachomatis by means of the indirect immunofluorescence technique. In 81% of the sera of patients with e.p., antibody could be detected, while patients with i.u.p. revealed antibody in 39%. Titres greater than or equal to 1:128 were found in 49% (e.p.) and in only 11% (i.u.p.) respectively; so they possess a high diagnostic value. These results show significant differences in the behaviour of antibodies in both groups of patients and are illustrated in 2 charts. Anamnestic data showed 54% of the patients with e.p. (i.e. adnexitis 23%, gonorrhea 12.3%, previous e.p. 18.4%); the mean age was 29 years. Affected tubes may lose their physiological function, possibly resulting in an ectopic pregnancy. The level of antibody in the serum remains stabile for many years, this enables a retrospective diagnosis of chlamydial infections. An early diagnosis and treatment, including the partners, represent the best way for prevention of complications.

[Chlamydia infections in the gynecology outpatient clinic]. / Chlamydieninfektionen in der gynäkologischen Poliklinik.

Chlamydia trachomatis is a common agens of non-specific genitourinary inflammatory conditions. We examined 269 female outpatients of the clinic. For 16 per cent of the patients Chlamydia trachomatis could be isolated. In these positive cases we found the following distribution: 32.5 per cent in the cervix and urethra, 60.5 per cent only in the cervix and 7 per cent only in the urethra. The clinical symptoms and importance of the disease are discussed.

[Estimation of 131I hippuran clearance during pregnancy (author's transl)]. / Bestimmung der 131J-Hippuratclearance im Verlaufe der Schwangerschaft.

Changes in 131I hippuran clearance were estimated by a non-catheter method, as well as total clearance and clearance of each kidney, in 43 women at various stages of pregnancy and in 13 non-pregnant women who were not using hormonal contraceptives. The results are demonstrated in graph form. The methods used are described in detail. The procedure for determining clearance in separate kidneys is indicated. It was found that clearance values increased up to the 35th and 36th weeks of pregnancy. The difference between the sides that were found corresponds with the previously known difference in the function of the right and left kidneys and ureters.

[Studies on renal function in H-gestosis using renal sequence scintigraphy and 131-J-hippurate clearance (author's transl)]. / Untersuchungen zur Nierenfunktion bei H-Gestose mit der Nierensequenzszintigraphie und 131-J-Hippuratclearance.

The article comments on the results of a study conducted in 23 women with H-gestosis, in 43 gravidae of the corresponding period of gestation with healthy kidneys, as well as in a control group of 13 women with healthy kidneys, in order to determine, by means of renal sequence scintigraphy and 131-J-hippurate clearance, the change in renal function caused by H-gestosis. The clearance data are shown both globally and broken down according to the individual kidneys. Typical activity-time curves of the relevant groups under examination are also demonstrated. The results show that with mild to moderate H-gestosis, the clearance equivalents are just below the values found in pregnancy without complications, the difference not being statistically significant. In the 28th-34th week of pregnancy, the elimination phase above the right renal parenchyma "regions of interest" is enhanced in a partly statistically significant manner, compared with the corresponding control group.

[Clinical studies on the effect of pregnancy and labor on the pharmacokinetics of ampicillin]. / Klinische Untersuchungen zum Einfluss von Schwangerschaft und Geburt auf die Pharmakokinetik von Ampizillin.

After giving 5 g Ampicillin intravenously to a total of 33 women (gravidae during the VIII. month pregnancy, women in labor and health controll persons) the serum levels of the mothers were analysed according to the pharmacokinetic parameter half-life of elimination.--Our results show that only the delivery cause significant differences of the kinetic of ampicillin.--Our results are discussed with the data given by literature.

[Correlation of antenatal cardiotocogram and amnioscopy in the management of pregnant women with prolonged pregnancy]. / Korrelation von antenatalem Kardiotokogramm und Amnioskopie bei der Uberwachung von Schwangeren nach Uberschreitung des errechneten Geburtstermins

In 125 women whose pregnancy continued for more than the calculated date of delivery 171 CTG were written and the parameters were analysed quantitatively. The lead of the CTG involved an amnioscopy in each case. The findings were compared with each other and with the condition of the newborn. The results show: 1. The normal value for the density of fluctuation-types (given by Rüttgers [15]) exceed in our cases. 2. A significant increase of density for the silent fluctuation-type was demonstrated well overdue of the calculated date. 3. There is no close correlation between the findings of the amniotic fluid and the characteristerics of CTG in excess of the fixed birthdate, even if the newborns show symptoms of overmaturity. The combined application of amnioscopy and prenatal CTG are considered as valuable methods to recognise the fetal risk early in post-term birth.

[The significance of meconium-containing amniotic fluid at the onset of labor following a normal pregnancy]. / Bedeutung von mekoniumhaltigem Fruchtwasser zu Beburtsbeginn nach normalem Schwangerschaftsverlauf

The delivery process of 218 gravids admitted after a normal course of pregnancy with meconium containing amniotic fluid are analysed. The higher operative frequency (25,2%) in comparison with the test group (10,9%) and the fact that in 4 fetuses the pH value on admission was under 7,20 confirm the recommendation to make obligatory the admission amnioscopy of all gravids at the beginning of birth. This practice involves continuous medical shift work. The perinatal mortality of the analysed deliveries was 0,46%.