Neuropsychological Performance in Alzheimer's Disease versus Late-Life Depression: A Systematic Review and Meta-Analysis.

OBJECTIVE: Despite decades of research, neuropsychological tests (NPTs) that clearly differentiate between Alzheimer's disease (AD) and late-life depression (LLD) have yet to be agreed upon. Given this gap in knowledge and the rapid deployment of disease-modifying drugs for the two disorders, accurate clinical diagnosis using evidence-based assessment is essential. This study aims to systematically examine the literature to identify NPTs that would be able to differentiate AD and LLD. METHOD: Databases and bibliographies were searched to identify articles for analysis. Two major inclusion criteria were that the studies compared neuropsychological functioning of AD versus LLD using normed NPTs and provided data for effect size calculation. Risk of bias was minimized by having independent coders for all steps in the review. RESULTS: Forty-one studies met inclusion criteria (N = 2,797) and provided effect sizes for tests that were classified as belonging to 15 domains of functioning. The two groups were well differentiated by tasks of delayed contextual verbal memory as compared to immediate or non-contextual memory, recognition cueing, confrontation naming, visuospatial construction, and conceptualization. Specific NPTs that appear to be useful for differential diagnosis include the Rey Auditory Verbal Learning Test-Delayed Recognition; Boston Naming Test; the Dementia Rating Scale's memory, conceptualization, and construction subscales; and the CERAD Constructional Praxis. CONCLUSIONS: The NPTs highlighted in this systematic review could be used as a relatively simple and cost-effective method to differentiate between patients with cognitive dysfunction due to AD versus LLD.

Geometrical frustration versus Kitaev interactions in BaCo2(AsO4)2.

Recently, Co-based honeycomb magnets have been proposed as promising candidate materials to host the Kitaev spin liquid (KSL) state. One of the front-runners is BaCo2(AsO4)2 (BCAO), where it was suggested that the exchange processes between Co2+ ions via the surrounding edge-sharing oxygen octahedra could give rise to bond-dependent Kitaev interactions. In this work, we present and analyze a comprehensive inelastic neutron scattering (INS) study of BCAO with fields in the honeycomb plane. Combining the constraints from the magnon excitations in the high-field polarized state and the inelastic spin structure factor measured in zero magnetic field, we examine two leading theoretical models: the Kitaev-type [Formula: see text] model and the XXZ[Formula: see text]model. We show that the existing experimental data can be consistently accounted for by the XXZ[Formula: see text]model but not by the [Formula: see text] model, and we discuss the implications of these results for the realization of a spin liquid phase in BCAO and more generally for the realization of the Kitaev model in cobaltates.

Uncovering Footprints of Dipolar-Octupolar Quantum Spin Ice from Neutron Scattering Signatures.

Recent experiments on Ce_{2}Zr_{2}O_{7} suggest that this material may host a novel form of quantum spin ice, a three-dimensional quantum spin liquid with an emergent photon. The Ce^{3+} local moments on the pyrochlore lattice are described by pseudospin-1/2 degrees of freedom, whose components transform as dipolar and octupolar moments under symmetry operations. In principle, there exist four possible quantum spin ice regimes, depending on whether the Ising component is in the dipolar or octupolar channel, and two possible flux configurations of the emergent gauge field. In this Letter, using exact diagonalization and molecular dynamics, we investigate the equal-time and dynamical spin structure factors in all four quantum spin ice regimes using quantum and classical calculations. Contrasting the distinct signatures of quantum and classical results for the four possible quantum spin ice regimes and elucidating the role of quantum fluctuations, we show that the quantum structure factor computed for the π-flux octupolar quantum spin ice regime is most compatible with the neutron scattering results on Ce_{2}Zr_{2}O_{7}.

Sign Structure of Thermal Hall Conductivity and Topological Magnons for In-Plane Field Polarized Kitaev Magnets.

The appearance of half-quantized thermal Hall conductivity in α-RuCl_{3} in the presence of in-plane magnetic fields has been taken as a strong evidence for the Kitaev spin liquid. Apart from the quantization, the observed sign structure of the thermal Hall conductivity is also consistent with predictions from the exact solution of the Kitaev honeycomb model. Namely, the thermal Hall conductivity changes sign when the field direction is reversed with respect to the heat current, which is perpendicular to one of the three nearest neighbor bonds on the honeycomb lattice. On the other hand, the thermal Hall conductivity is almost zero when the field is applied along the bond direction. Here, we theoretically demonstrate that such a peculiar sign structure of the thermal Hall conductivity is a generic property of the polarized state in the presence of in-plane magnetic fields. In this case, the thermal Hall effect arises from topological magnons with finite Chern numbers, and the sign structure follows from the symmetries of the momentum space Berry curvature. Using a realistic spin model with bond-dependent interactions, we show that the thermal Hall conductivity can have a magnitude comparable to that observed in the experiments. Hence, the sign structure alone cannot make a strong case for the Kitaev spin liquid. The quantization at very low temperatures, however, will be a decisive test as the magnon contribution vanishes in the zero temperature limit.