Differential characteristics of carbon emission efficiency and coordinated emission reduction pathways under different stages of economic development: Evidence from the Yangtze River Delta, China.

Regional carbon emission efficiency (CEE) has differentiated characteristics under different economic development stages and patterns, and identifying such characteristics is important for formulating corresponding policies for high-quality regional development. Using input‒output data related to economic development and energy consumption, a comprehensive evaluation model of the Super-SBM and Malmquist‒Luenberger (ML) index is constructed to evaluate the spatial and temporal changes and driving forces of CEE. Based on this index, a proposal is designed for collaborative carbon emission reduction zoning. The results indicate that the CEE of the Yangtze River Delta shows a fluctuating upward trend with obvious spatial agglomeration characteristics, and CEE changes are closely related to economic development stages. The annual average CEE values in each stage show positive changes, indicating that economic development gradually evolves to low carbonization levels. Moreover, CEE improvement gradually shifts from being driven by efficiency changes to being driven by technological changes. Finally, according to the characteristics of total carbon emissions and the efficiency of different cities, a synergistic emission reduction path is proposed with four aspects: land use optimization, ecological co-preservation, innovation cooperation and low carbon development.

Inhibition of Three Diabetes-Related Enzymes by Procyanidins from Lotus (Nelumbo nucifera Gaertn.) Seedpods.

The inhibitory effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpods on the activities of α-amylase, α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), were studied and compared with those of (+)-catechin, (-)-epicatechin, epigallocatechin gallate (EGCG), procyanidin dimer B2 and trimer C1. The results showed that Lotus procyanidin extract (LPE) significantly inhibited α-amylase, α-glucosidase and PTP1B with IC50 values of 5.5, 1.0, and 0.33 µg/mL, respectively. The inhibition increased with the degree of polymerization and the existence of galloyl or gallocatechin units. Kinetic analysis showed that LPE inhibited α-glucosidase activity in a mixed competitive and noncompetitive mode. Fluorescence quenching revealed that α-glucosidase interacted with LPE or EGCG in an apparent static mode, or the model of "sphere of action". The apparent static (K) and bimolecular (kq) constants were 4375 M-1 and 4.375 × 1011 M-1 s-1, respectively, for LPE and 1195 M-1 and 1.195 × 1011 M-1 s-1, respectively, for EGCG. Molecular docking analysis provided further information on the interactions of (+)-catechin, (-)-epicatechin, EGCG, B2 and C1 with α-glucosidase. It is hypothesized that LPE may bind to multiple sites of the enzyme through hydrogen bonding and hydrophobic interactions, leading to conformational changes in the enzyme and thus inhibiting its activity. These findings first elucidate the inhibitory effect of LPE on diabetes-related enzymes and highlight the usefulness of LPE as a dietary supplement for the prophylaxis of diabetes.

The response of grain production to changes in quantity and quality of cropland in Yangtze River Delta, China.

BACKGROUND: Cropland in Yangtze River Delta has declined drastically since economic reforms in 1978 that led to rapid economic development. Such cropland loss due to population growth has led to a decline in grain production. This study aimed at analyzing the impact of land use changes on grain production. To achieve this, the spatiotemporal dynamics of cropland during 1980-2010 were analyzed. Irrigation and soil fertility data were used as additional lines of evidence. RESULTS: Cropland loss had negative impacts on grain production. About 80 and 66% of grain production decreased during 1980-2005 and 2005-2010 respectively. This decline was attributed to the conversion of cropland to built-up areas. Abandoned cropland areas were mainly concentrated in regions with high irrigation capability and high soil fertility, while cropland reclamation was mainly in areas with low irrigation and soil fertility, implying that, although cropland was reclaimed, production remained low. The decline in cropland area has reinforced the chronic food insecurity in Yangtze River Delta. CONCLUSION: This study demonstrated the response of grain production to the changes in cropland quantity and quality. It also provides scientific evidence for decision makers to protect cropland and enhance grain production.