Correlation between subclinical hypothyroidism and carotid atherosclerosis in patients with acute ischemic stroke / 国际脑血管病杂志

Objective To investigate the correlation between subclinical hypothyroidism (SCH) and carotid atherosclerosis in patients with acute ischemic stroke.Methods Patients with acute ischemic stroke admitted to Nanjing Shengze Hospital Affiliated to Nanjing Medical University from July 2014 to July 2017 were enrolled retrospectively.SCH was defined as elevated levels of serum thyroid stimulating-hormone (TSH),but the free thyroxine (FT4) and free-triiodothyronine (FT3) levels were normal.Carotid plaque and carotid stenosis were assessed using carotid ultrasound.Multivariate logistic regression analysis was used to determine the correlation between SCH and carotid atherosclerosis.Resuts A total of 176 patients with acute ischemic stroke were enrolled,including 81 females and 95 males;36 complicated with SCH,126 complicated with carotid atherosclerotic plaques,and 9 had carotid stenosis.High-density lipoprotein cholesterol (1.36±0.48 mmol/L vs.1.18 ± 0.30 mmol/L;t =2.090,P =0.039) and TSH (6.29[5.44-7.01]mU/L vs.1.87[1.31-2.67] mU/L;Z =9.243,P =0.001) levels in the SCH group were significantly higher than those in the non-SCH group.There were significant differences in age (73.5[65.0-80.0]years vs.68.0[56.0-75.0]years;Z =2.707,P=0.007),stroke etiology classification (x2 =9.270,P=0.038),TSH level (2.19[1.47-3.72]mU/L vs.2.18[1.24-2.62]mU/L;Z=3.230,P=0.001),and the proportion of patients with SCH (26.98％ vs.4.00％;x2 =11.622,P =0.001) between the plaque group and the non-plaque group.There was no statistical difference in demographic and clinical data between the stenosis group and the non-stenosis group (all P ＞0.05).Multivariatelogistic regression analysis showed that advanced age (odds ratio 1.050,95％ confidence interval 1.014-1.088;P =0.006) and SCH (odds ratio 5.328,95％ confidence interval 1.322-21.468;P =0.019) were the independent risk factors for carotid atherosclerotic plaques.Conclusion Advanced age and SCH were the independent risk factors for carotid plaque in patients with acute ischemic stroke.

Risk factors for ischemic stroke complicated with atherosclerotic plaques of lower extremities / 国际脑血管病杂志

Objective To investigate the risk factors for acute ischemic stroke in patients with lower extremity atherosclerosis (LEA).Methods The consecutive patients with acute ischemic stroke admitted to hospital within 7 d after onset were enrolled retrospectively.Color Doppler flow imaging was used to detect LEA.The demographic characteristics,vascular risk factors,and laboratory parameters were identified and analyzed.Results A total of 156 patients with acute ischemic stroke were enrolled,including 138 with LEA.Univariate analysis showed that age (69.5± 11.8 years vs.60.4± 11.5 years;t =3.063,P =0.003) and the proportion of patients with hypertension (81.1％ vs,55.6％;x2 =2.467,P =0.014) in the LEA group were significantly higher than those in the non-LEA group.Multivariate logistic regression analysis showed that after adjustment for confounders such as gender,baseline systolic blood pressure,diabetes mellitus,and ischemic heart disease,age (odds ratio [OR] 1.059,95％ confidence interval [CI] 1.016-1.105;P=0.007),and hypertension (OR 3.128,95％ CI 1.084-9.026,P =0.035) were the independent risk factors for acute ischemic stroke complicated with LEA.Conclusions Age and hypertension are associated with acute ischemic stroke complicated with LEA.

Comparative study of anatomic locking compression plate and anatomic plate fixation for Pilon fracture / 中国基层医药

Objective To compare the clinical effect of locking compression plate and anatomic plate fixation for Pilon fracture.Methods 68 patients with tibial Pilon fracture were selected and divided into two groups according to the random number table method,34 cases in each group,the observation group was given lock plus pressure plate fixation while the control group received anatomic plate for treatment,the clinically relevant indicators,treatment effect and occurrence of complications of the two groups were compared.Results The operation time of the observation group[(46.46 ±3.56)min],incision length[(5.25 ±0.75)cm],blood loss[(36.77 ±5.12)mL],plaster braking time[(13.23 ±1.77)d],fracture healing time [(12.42 ±1.43 )weeks],postoperative hospital stay [(9.89 ± 1.88)d]were less than or shorter than those of the control group [(68.76 ±4.45 )min,(12.78 ±1.54)cm, (84.75 ±8.65)mL,(20.30 ±2.43)d,(18.94 ±2.30)weeks,(15.67 ±2.64)d],the differences were statistically significant(t =6.834,9.455,7.488,6.591,7.033,8.210,all P <0.05).The excellent rate of the observation group was 94.12%,which was higher than 80.00% of the control group,the difference was statistically significant(χ2 =8.238,P <0.05).The postoperative complications occurred in the observation group was 5.88%,which was signifi-cantly increased to 17.65% in the control group,the difference was statistically significant(χ2 =7.657,P <0.05). Conclusion Compared with anatomical plate fixation,the locking compression fixation for Pilon fractures can shorten the healing time and reduce the incidence of complications,so it is safe and has significant advantages for the clinical application.

Electroencephalogram slow wave activity of sleep disorders and mild cognitive impairment patients with Parkinson's disease / 中华神经医学杂志

Objective To observe the electroencephalogram (EEG) activity of sleep disorders and mild cognitive impairment (MCI) patients with Parkinson's disease (PD).Methods Forty-nine PD patients,admitted to our hospital from December 2012 to June 2013,were examined by Parkinson's Disease Rating Scale,Hospital Anxiety and Depression Scale,Pittsburgh Sleep Quality Scale (PSQS) and Scale Montreal Cognitive Assessment (MoCA); electroencephalogram and their clinic features were analyzed.Results As compared with the normal sleep and non-MCI patients with PD (61.8％),sleep disorder and MCI patients with PD showed higher incidence of slow wave (65.6％).Logistic regression analysis showed that sleep quality was positively correlated to the incidence of slow wave (OR=4.117,P=0.042).PD patients with slow wave had higher PSQS scores and lower MoCA scores as compared with PD patients without slow wave.Conclusion PD patients with sleep disorder and MCI show high incidence of slow wave.

Effect of floating acupuncture on the processus transverses of vertebrae lumbales Ⅲ syndrome / 中国康复理论与实践

@#ObjectiveTo explore the therapeutic effect of floating acupuncture on the the processus transverses of vertebrae lumbales Ⅲ syndrome.Methods40 patients with the processus transverses of vertebrae lumbales Ⅲ syndrome were divided into the floating acupuncture group (20 cases) and the traditional group (20 cases). The pain was evaluated with visual analogue scale (VAS) before and after treatment.ResultsCompared with traditional treatment, the floating acupuncture can relieve pain rapidly after 15 min and 1 d of treatment. ConclusionThe floating acupuncture shows preferable clinical curative effect to patients with the processus transverses of vertebrae lumbales Ⅲ syndrome.

The study of acupuncture for patients with vertebral-artery-type cervical spondylosis using TCD and BAEP / 中华物理医学与康复杂志

Objective To observe the effect of acupuncture on patients with vertebral-artery-type cervical spondylosis by means of transcranial Doppler sonography ~TCD) and brainstem auditory evoked potentials ~BAEP), and to explore the mechanism of acupuncture in treatment of cervical spondylosis by means of blood velocity and neuroelectrophysiology measurements. Methods Forty patients with vertebral-artery-type cervical spondylosis were divided into acupuncture treatment group ~20 cases) and routine treatment group ~20 cases). The TCD and BAEP were examined before the rehabilitation treatment and 2 week later. Comparing with the control group, the effect of acupuncture on the blood velocity and cerebral electrophysiology was analyzed. Results ~1)The total efficiency rates in the two treatment groups were 90% and 85%, respectively. The clinical heal rate was 45% in acupuncture group and 35% in routine group. There was no statistic difference with regard to the therapeutic effect and the length of treatment between the two groups. ~2)The blood velocity of vertebrobasilar artery ~VBA) in the patient group was decreased. The abnormal rate of TCD was 77.5% ~31/40 cases), characterized with the decrease of VBA. The abnormal rate of BAEP was 75% ~30/40 cases), characterized with brainstem abnormality type. ~3)The blood velocity in both groups was increased after treatment. Compared with the routine therapy group, the velocity of blood flow in vertebral artery in acupuncture treatment group was increased markedly ~P

Clinical study of standing bed for the orthostatic hypotension after cervical spinal cord injury / 中国康复理论与实践

@#ObjectiveTo observe the therapeutic effect of standing bed on orthostatic hypotension with cervical spinal cord injury. Methods36 patients with cervical spinal cord injury were divided randomly into the standing bed group and routine treatment group. The blood pressure of all patients were measured every day during rehabilitation treatment. The function of spinal cord was assessed before and after treatment.ResultsThe function of sensory and motor in the two groups were all improved, but there was no statistical difference between the two groups in the grades of spinal cord function. There were 27 patients who had orthostatic hypotension in the study. All the patients with complete spinal cord injury suffered the orthostatic hypotension. There was no improvement in blood pressure of complete spinal cord injury after treatment. In incomplete spinal cord injury patients, there was a significant improvement and the difference of blood presure between lying and standing was decreased in standing bed group after treatment (P<0.05). Compared with routine treatment group, the blood pressure in standing bed group was improved (P<0.05). Conclusions Cervical spinal cord injury could have orthostatic hypotension. Complete spinal cord injury would suffer orthostatic hypotension in different degree. The standing bed treatment could improve the orthostatic hypotension in incomplete spinal cord injury.