[The effect of tocopherol and nicotinic acid on the microcirculation and blood coagulability in patients with ischemic heart disease]. / Vliianie tokoferola i nikitinovoi kisloty na mikrotsirkuliatsiiu i svertyvaemost' krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Patients with ischemic heart disease were treated by routine techniques (53), using also tocopherol acetate (54) and combination of tocopherol with nicotinic acid (53). Changes of the microcirculatory bed of the bulbar conjunctiva was studied biomicroscopically and in the process of blood coagulation hemoelectrocoagulographically. Complex treatment using tocopherol acetate produced a positive effect on the coagulation properties of the blood and did essentially influence the fibrinolytic activity and microcirculation. Tocopherol plus nicotinic acid resulted in normalization of the blood coagulation process, favoured activation of fibrinolysis and improvement of the microcirculatory bed.

[Nicotinic acid in the treatment of chronic circulatory failure in patients with ischemic heart disease]. / Nikotinovaia kislota v lechenii khronicheskoi nedostatochnosti krovoobrashcheniia u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Examined were 98 patients with chronic forms of ischemic heart disease, mainly atherosclerotic cardiosclerosis with different degrees of cardiac insufficiency. Two groups were distinguished. Patients of the first group received traditional treatment while patients of the second group received also nicotinic acid agents. It was found that inclusion of nicotinic acid in the complex treatment of patients with ischemic heart disease increased the therapeutic efficacy.