Histidine Metabolic Pathway Contributes to Clozapine-Induced Sialorrhea Based on Nontargeted Metabolomics.

INTRODUCTION: Clozapine-induced sialorrhea (CIS) is one of the most common side effects of clozapine use, while the mechanism remains unclear. METHODS: A total of 51 schizophrenia patients taking clozapine were selected. Among them, 32 had sialorrhea, and 19 had no sialorrhea. Saliva metabolites were identified using ultra-high-performance liquid chromatography-MS/MS (UHPLC-MS/MS), and the differences in saliva metabolites in each group were analyzed through qualitatively searching HMDB, KEGG, and self-built databases, combined with multivariate statistics. After further evaluation by receiver-operating characteristic curve (ROC) analysis, the screened differential metabolites were enriched and topologically analyzed. RESULTS: The biomarkers potentially related to CIS included 37 differential metabolites involving 17 metabolic pathways, mainly histidine metabolism (p < 0.05, impact = 0.50), pyrimidine metabolism (p < 0.05, impact = 0.08), and ß-alanine metabolism (p < 0.05, impact = 0.06). CONCLUSION: Our study indicates that histidine metabolic pathway may contribute to the mechanism of CIS.

Data Storage Mechanism Based on Blockchain with Privacy Protection in Wireless Body Area Network.

Wireless body area networks (WBANs) are expected to play a vital role in the field of patient-health monitoring shortly. They provide a convenient way to collect patient data, but they also bring serious problems which are mainly reflected in the safe storage of the collected data. The privacy and security of data storage in WBAN devices cannot meet the needs of WBAN users. Therefore, this paper adopts blockchain technology to store data, which improves the security of the collected data. Moreover, a storage model based on blockchain in WBAN is proposed in our solution. However, blockchain storage brings new problems, for example, that the storage space of blockchain is small, and the stored content is open to unauthorized attackers. To solve the problems above, this paper proposed a sequential aggregate signature scheme with a designated verifier (DVSSA) to ensure that the user's data can only be viewed by the designated person and to protect the privacy of the users of WBAN. In addition, the new signature scheme can also compress the size of the blockchain storage space.

Data Query Mechanism Based on Hash Computing Power of Blockchain in Internet of Things.

In the IoT (Internet of Things) environment, smart homes, smart grids, and telematics constantly generate data with complex attributes. These data have low heterogeneity and poor interoperability, which brings difficulties to data management and value mining. The promising combination of blockchain and the Internet of things as BCoT (blockchain of things) can solve these problems. This paper introduces an innovative method DCOMB (dual combination Bloom filter) to firstly convert the computational power of bitcoin mining into the computational power of query. Furthermore, this article uses the DCOMB method to build blockchain-based IoT data query model. DCOMB can implement queries only through mining hash calculation. This model combines the data stream of the IoT with the timestamp of the blockchain, improving the interoperability of data and the versatility of the IoT database system. The experiment results show that the random reading performance of DCOMB query is higher than that of COMB (combination Bloom filter), and the error rate of DCOMB is lower. Meanwhile, both DCOMB and COMB query performance are better than MySQL (My Structured Query Language).