1.
J Org Chem
; 89(4): 2656-2664, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38324782
RESUMO
We have developed a metal-free photocatalytic selective hydroxylation of benzylic methylenes to secondary alcohols. This approach utilizes low-cost eosin Y as photocatalyst, O2 as green oxidant, and inexpensive triethylamine as inhibitor for overoxidation. The mild reaction conditions enable the production of secondary alcohols with 56-95% yields, making it a promising and environmental-friendly method for the synthesis of secondary alcohols from benzylic methylenes.