RESUMO
(±)-Heterocageflavone (1), a pair of enantiomeric isoprenylated flavonoids, were isolated from Artocarpus heterophyllus. Compound 1 incorporates an unusual tricyclo[5.3.1.03,8]undecane moiety, forming a unique caged polycyclic system. The structures of the pair were determined by spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction. Compound 1 showed significant inhibitory activity against LPS-induced NO production in RAW264.7 cells with an IC50 value of 49.2 µM.
Assuntos
Artocarpus , Alcanos , Anti-Inflamatórios/farmacologia , Artocarpus/química , Flavonoides/química , Flavonoides/farmacologiaRESUMO
The title compound, C15H14BrN, has an E conformation about the C=N bond and the dihedral angle between the benzene rings is 50.7â (2)°. In the crystal, mol-ecules are linked via C-Hâ¯π inter-actions, forming columns propagating along [010].
RESUMO
In the title compound, C15H14BrN, the dihedral angle between the benzene rings is 6.4â (2)° and the mol-ecule has an E conformation about the C=N bond. In the crystal, mol-ecules are linked by C-Hâ¯π inter-actions, forming two-dimensional networks lying parallel to (001).