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1.
Phys Rev Lett ; 132(6): 066101, 2024 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-38394575

RESUMO

Superelastic alloys used for stents, biomedical implants, and solid-state cooling devices rely on their reversible stress-induced martensitic transformations. These applications require the alloy to sustain high deformability over millions of cycles without failure. Here, we report an alloy capable of enduring 10×10^{7} tensile stress-induced phase transformations while still exhibiting over 2% recoverable elastic strains. After millions of cycles, the alloy is highly reversible with zero stress hysteresis. We show that the major martensite variant is reversible even after multimillions of cycles under tensile loadings with a highly coherent (11[over ¯]0)_{A} interface. This discovery provides new insights into martensitic transformation, and may guide the development of superelastic alloys for multimillion cycling applications.

2.
J Anim Sci ; 1012023 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-37583344

RESUMO

We investigated the effects of different Bacillus subtilis QST713 doses and a B. subtilis QST713 and ß-mannanase mix on growth performance, intestinal barrier function, and gut microbiota in weaned piglets. In total, 320 healthy piglets were randomly assigned to four groups: 1) control group (basal diet), 2) BS100 group (basal diet plus 100 mg/kg B. subtilis QST713), 3) BS200 group (basal diet plus 200 mg/kg B. subtilis QST713), and 4) a BS100XT group (basal diet plus 100 mg/kg B. subtilis QST713 and 150 mg/kg ß-mannanase). The study duration was 42 d. We showed that feed intake in weaned piglets on days 1 to 21 was increased in group BS100 (P < 0.05), and that the feed conversion ratio in group BS100XT animals decreased throughout the study (P < 0.05). In terms of microbial counts, the BS100XT group showed reduced Escherichia coli and Clostridium perfringens numbers on day 21 (P < 0.05). Moreover, no significant α-diversity differences were observed across all groups during the study (P > 0.05). However, principal coordinates analysis indicated clear separations in bacterial community structures across groups (analysis of similarities: P < 0.05) on days 21 and 42. Additionally, E-cadherin, occludin, and zonula occludens-1 (ZO-1) expression in piglet feces increased (P < 0.05) by adding B. subtilis QST713 and ß-mannanase to diets. Notably, this addition decreased short-chain fatty acid concentrations. In conclusion, B. subtilis QST713 addition or combined B. subtilis QST713 plus ß-mannanase effectively improved growth performance, intestinal barrier function, and microbial balance in weaned piglets.


The use of antibiotics in pig farming raises serious concerns in terms of antibiotic resistance. Consequently, alternative approaches such as probiotics, including Bacillus subtilis, and enzymes such as ß-mannanase, have been proposed to improve pig health and performance. In particular, B. subtilis improves gut microbiota and reduces the prevalence of harmful bacteria such as Escherichia coli and Clostridium perfringens. Similarly, ß-mannanase enhances feed digestibility and improves nutrient use in pigs. Thus, combined B. subtilis and ß-mannanase may provide synergistic effects toward pig performance and gut health. In this study, we showed that adding B. subtilis to a weaned piglet diet improved feed intake, while a B. subtilis and ß-mannanase mix reduced feed conversion ratios in weaned piglets.


Assuntos
Microbioma Gastrointestinal , Animais , Suínos , Bacillus subtilis , beta-Manosidase/farmacologia , Dieta/veterinária , Fezes/microbiologia , Escherichia coli
3.
Nano Lett ; 20(11): 8332-8338, 2020 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-33078611

RESUMO

Both crystallographic compatibility and grain engineering are super critical to the functionality of shape memory alloys, especially at micro- and nanoscales. Here, we report a bicrystal CuAl24Mn9 micropillar engraved at a high-angle grain boundary (GB) that exhibits enhanced reversibility under very demanding driving stress (about 600 MPa) over 10 000 transformation cycles despite its lattice parameters are far from satisfying any crystallographic compatibility conditions. We propose a new compatibility criterion regarding the GB for textured shape memory alloys, which suggests that the formation of GB compatible twin laminates in neighboring textured grains activates an interlock mechanism, which prevents dislocations from slipping across GB.

4.
Proc Natl Acad Sci U S A ; 111(47): 16872-6, 2014 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-25385619

RESUMO

Johnson-Lindenstrauss (JL) matrices implemented by sparse random synaptic connections are thought to be a prime candidate for how convergent pathways in the brain compress information. However, to date, there is no complete mathematical support for such implementations given the constraints of real neural tissue. The fact that neurons are either excitatory or inhibitory implies that every so implementable JL matrix must be sign consistent (i.e., all entries in a single column must be either all nonnegative or all nonpositive), and the fact that any given neuron connects to a relatively small subset of other neurons implies that the JL matrix should be sparse. We construct sparse JL matrices that are sign consistent and prove that our construction is essentially optimal. Our work answers a mathematical question that was triggered by earlier work and is necessary to justify the existence of JL compression in the brain and emphasizes that inhibition is crucial if neurons are to perform efficient, correlation-preserving compression.


Assuntos
Modelos Biológicos , Neurociências
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