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Medicated effect of CDKN1B on promoting proliferation of islet β cells in diabetes mellitus / 中国综合临床
Clinical Medicine of China
; (12): 233-236, 2023.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-992495
RESUMO
The serious decrease in the number of functional β cells is one of the main features in the pathogenesis of diabetes mellitus. CDKN1B is a new kind of regulatory protein, which can bind and inactivate cyclin and cyclin-dependent kinase complex to control the process of cell cycle. It was suggested that down-regulation or deletion of CDKN1B in islet β cells could accelerate the proliferation of islet β cells, thus increasing the number of islet β cells, which is of great significance for treatments of diabetes.