RESUMO
The aim of the present work was to analyze the reported data related to the diagnostic potential of delineating the degree of blood vessel involvement into the tumorous process in patients with cancer diseases of varying sites and to the choice of the method for surgical treatment of this group patients. Half century ago an idea was advanced of the necessity of performing vascular operations during evacuation of tumors of certain sites. Based on the analysis of numerous publications the authors have established that the lowering of the lethality and improvement of the quality of life in patients with oncopathology are determined in many respects by one-stage operations performed on the great vessels, allowing to broaden the indications for tumor resection. The review elucidates the current achievements of vascular surgery linked with oncology, mirrors the historical viewpoint of the given problem, describes an experience of different authors gained with the use of the modern noninvasive research modalities in the diagnosis of vascular involvement into tumorous growth. As dependent on the site, tumor morphology and hemodynamic significance of the affected vascular segment, the indications have been worked out for different types of operations on the arteries and veins. The authors emphasize the potential and safety of great vessel ligation after radical resection of tumors of certain sites.
Assuntos
Neoplasias/irrigação sanguínea , Neoplasias/cirurgia , Procedimentos Cirúrgicos Vasculares/métodos , HumanosRESUMO
The importance of NK-cells was shown in 12 patients with nephroblastoma and 10 patients with neuroblastoma using ICO-11 monoclonal antibodies. The numbers of circulating LFA-1+ cells were shown to be different in the untreated and treated patients. A certain regular influence of antitumour therapy on the amount of circulating LFA-1+ cells was established.
Assuntos
Anticorpos Monoclonais , Antígenos de Neoplasias/análise , Antígenos de Superfície/análise , Neoplasias Renais/imunologia , Neuroblastoma/imunologia , Tumor de Wilms/imunologia , Adolescente , Criança , Pré-Escolar , Terapia Combinada , Feminino , Imunofluorescência , Humanos , Lactente , Neoplasias Renais/terapia , Células Matadoras Naturais/imunologia , Antígeno-1 Associado à Função Linfocitária , Masculino , Neuroblastoma/terapia , Tumor de Wilms/terapiaRESUMO
The possibility to reveal the following types of neuroblastoma is described: with c-ALL-antigen; with Thy-1-antigen (ICO-10); with granulocytic antigen (ICO-G2); with B-cell antigen (IPO-10). Immunocompetent cells in the tumour may be studied with the use of monoclonal antibodies ICO-1, ICO-11, ICO-GM-1, OKT3, IPO-3.
Assuntos
Anticorpos Monoclonais , Neuroblastoma/imunologia , Criança , Feminino , Humanos , MasculinoRESUMO
Peripheral blood lymphocytes were studied in 22 pediatric patients suffering nephroblastoma and neuroblastoma. Monoclonal antibodies were used. Failure of T-cell immunity was registered in both groups. Nephroblastoma patients revealed high levels of natural killer cells. Immunity was studied versus clinical stage, duration of disease and response. Immunocorrection modalities are discussed.