Outcomes and predictors of treatment failure after anti-reflux mucosectomy for management of gastroesophageal reflux disease.

BACKGROUND: Anti-reflux mucosectomy is a novel endoscopic treatment for gastroesophageal reflux disease that serves as an intermediate therapy between medical and surgical intervention. We aimed to evaluate outcomes and identify predictors of treatment failure in patients requiring anti-reflux mucosectomy. METHODS: A prospective quality database was retrospectively reviewed. Upper endoscopy, pH testing, and functional luminal impedance planimetry were obtained at preop and 1 year post-operation. Quality of life outcomes were assessed by Gastroesophageal Reflux Disease-Health Related Quality of Life, Reflux Symptom Index, and dysphagia scores preoperatively and up to 5 years postoperatively. RESULTS: Fifty-eight patients requiring anti-reflux mucosectomy were analyzed between 2016 and 2023. Preop Gastroesophageal Reflux Disease-Health Related Quality of Life mean scores improved at all time points 3 weeks to 2 years postoperatively (all P < .05). Preop mean Reflux Symptom Index scores also significantly improved at 6-month, 1-year, and 2-year timepoints (all P < .05). Dysphagia at 3 weeks was higher than preop scores (1.2 vs 2.1, P < .01) but returned to baseline. Upon follow-up, 43 patients (74.1%) had symptom improvement off proton pump inhibitors, 29 of whom reported complete symptom resolution. Out of 58 patients, 31 (53.4%) failed treatment due to DeMeester score (n = 22), erosive esophagitis (n = 2), Gastroesophageal Reflux Disease-Health Related Quality of Life ≥13 (n = 4), or <70% symptom resolution in the absence of pH or survey data (n = 3). Current smoking status was predictive of treatment failure (odds ratio 3.52, P < .031). Body mass index, DeMeester score, acid exposure time, and hiatal hernia ≤2 cm were not associated with treatment failure. CONCLUSION: Anti-reflux mucosectomy is associated with significant improvement in quality of life; however, symptom resolution may not correlate with objective reflux control. Smoking is a predictor of treatment failure and should be considered in patient selection.

Applying VitalTalkTM Techniques to Best Case/Worst Case Training to Increase Scalability and Improve Surgeon Confidence in Shared Decision-making.

OBJECTIVE: Best Case/Worst Case (BC/WC) is a communication tool designed to promote shared decision-making for high-risk procedures near the end of life. This study aimed to increase scalability of a BC/WC training program and measure its impact on surgeon confidence in and perceived importance of the methodology. DESIGN: A prospective cohort pre-post study; December 2018 to January 2019. SETTING: Multi-center tertiary care teaching hospital. PARTICIPANTS: Forty-eight resident surgeons from general surgery and otolaryngology. RESULTS: Learners were 24 to 37 years old with 52% in post graduate year 1 to 2. Although learners encountered high-stakes communication (HSC) frequently (3.6 [0.7] on 5-point Likert scale), most reported no HSC training in medical school (74.5%) or residency (87.5%). BC/WC training was accomplished with an instructor to learner ratio of 1-to-5.3. After training, learner confidence improved on all measured communication skills on a 5-point scale (e.g., exploring patient's values increased from 3.6 [0.8] to 4.1 [0.6], p = <0.0001); average within-person improvement was 0.72 (0.6) points across all skills. Perceived importance improved across all skills (e.g., basing a recommendation on patient's values increased from 4.4 [0.8] to 4.8 [0.5], p = 0.0009); average within-person improvement was 0.46 (0.5) points across all skills. Learners reported this training would likely help them in future interactions (4.4 [0.73] on 5-point scale) and 95.2% recommended it be offered to resident physicians in other residency programs and to attending surgeons. CONCLUSIONS: Formal training in BC/WC increases learners' perception of both the importance of HSC skills and their confidence in exercising those skills in clinical practice. VitalTalkTM methodology permitted scaling training to 5.3 learners per instructor and was highly recommended for other surgeons. Ongoing training, such as this, may support more patient-centered decision-making and care.

Upper limb neurodynamic test of the radial nerve: a study of responses in symptomatic and asymptomatic subjects.

STUDY DESIGN: Clinical measurement. INTRODUCTION: Nonspecific cervical pain is a common clinical presentation. The role of upper limb neurodynamic tests (ULNT), for evaluation and treatment intervention, is not well defined for this population. PURPOSE OF THE STUDY: This study's purpose was to determine if the radial-biased (RB)-ULNT discriminates any response differences between symptomatic subjects with a positive (+) RB-ULNT (n=36), symptomatic subjects with a negative (-) RB-ULNT (n=24), and asymptomatic subjects (n=60). METHODS: Sixty asymptomatic and 60 subjects presenting with nonspecific cervical and/or unilateral upper extremity pain were compared using the RB-ULNT. Symptomatic subjects were further divided in (+) and (-) RB-ULNT groups due to their response to the RB-ULNT. Within the symptomatic population, a positive response to the RB-ULNT was defined by the symptomatic subject reporting their sensations were increased with contralateral cervical lateral flexion and decreased with ipsilateral cervical lateral flexion. Sensation provocation and location were evaluated using the RB-ULNT in all the subjects during each stage of the testing. RESULTS: Significant differences on stage of reproduction and type of sensations were identified between 1) the (+) RB-ULNT symptomatic subjects, 2) the (-) RB-ULNT symptomatic subjects, and 3) the asymptomatic subjects. The (+) RB-ULNT group showed significantly increased pain responses during the first stage of the RB-ULNT compared with the (-) RB-ULNT group and the asymptomatic subjects. The (+) RB-ULNT also showed significantly decreased glenohumeral abduction passive range of motion when compared with the asymptomatic group. CONCLUSION: Clinically, the differences found between the groups in their response to the RB-ULNT suggest heightened mechanosensitivity in the (+) RB-ULNT group. LEVEL OF EVIDENCE: 3a.

A new measurement method for spine reposition sense.

BACKGROUND: A cost effective tool for the measurement of trunk reposition sense is needed clinically. This study evaluates the reliability and validity of a new clinical spine reposition sense device. METHODS: The first part of this three part investigation included 45 asymptomatic subjects examined in the first 20 repeated trials portion assessing spine reposition sense. The second portion, test-retest, examined 57 asymptomatic subjects. Initial testing consisted of subjects sitting on the device and performing 20 trials of a self-determined 2/3 trunk flexion position. The second portion of the study involved 7 trials of trunk flexion performed twice. The angular position for each trial was calculated and the mean reposition error from the initial 2/3 position was determined. For the third portion, the new device was compared to the Skill Technologies 6D (ST6D) Imperial Motion Capture and Analysis System. RESULTS: ICC (3,1) for trials 4-7 was 0.79 and 0.76 for time one and time two, respectively and the test-retest ICC (3,k) was 0.38. Due to the poor test-retest ICC, the Bland Altman method was used to compare test and retest absolute errors. Most measurement differences were small and fell within the 95% confidence interval. Comparable measures between the two methods were found using the Bland Altman method to compare the reposition sense device to the ST6D system. CONCLUSION: The device may be a cost effective clinical technique for sagittal trunk reposition sense measurement.

Electromyographic Analysis of a Repetitive Hand Gripping Task.

Electromyography (EMG) has been proposed as a method for determining muscle effort in repetitive upper limb tasks, which are often related to cumulative trauma disorders. EMG activity of the finger flexor musculature was investigated during a repetitive hand gripping task having 5 different cycle durations (2 to 6 s), various percentage of work time (and rest) within the work cycle (20% to 80%), and 3 different grip force levels. Thirty healthy adult participants each performed 27 randomly ordered 30-s repetitive hand gripping trials as well as 3 isometric contractions, which were used to normalize data from the hand gripping trials. There was a significant decrease in mean EMG as the duration of the work-rest cycle time increased. At each force level, EMG increased as the percentage of work time within the work-rest cycle increased, but to a greater extent at the highest force level. The results of this study suggest that overall muscle effort, and perhaps muscle fatigue, can be reduced most effectively by modifying the force requirements of the repetitive task. Other variables, such as the percentage of work time within a cycle and overall work cycle time have less effect on the EMG activity level. The results of this study have implications for developing strategies to reduce muscle fatigue during repetitive hand gripping tasks in an effort to reduce the effects of cumulative trauma disorders.