RESUMO
The research is devoted to establishing of early diagnostic, differential-diagnostic criteria and the prognosis of hypixemic-ischaemic damage of central nervous system (that differs due to characteristics and the degree of complexity) of preliminary-born in acuity on the basis of their complex interdisciplinary research (anamnesis, neurological, clinical, instrumental--neurovoiceprint, immune-enzyme, in particular the dynamics of quantity level changes of brain-derived neurotropic factor in blood serum).
Assuntos
Edema Encefálico/diagnóstico , Hipóxia-Isquemia Encefálica/diagnóstico , Hemorragias Intracranianas/diagnóstico , Leucomalácia Periventricular/diagnóstico , Doença Aguda , Edema Encefálico/sangue , Edema Encefálico/etiologia , Fator Neurotrófico Derivado do Encéfalo/sangue , Diagnóstico Diferencial , Humanos , Hipóxia-Isquemia Encefálica/sangue , Hipóxia-Isquemia Encefálica/complicações , Recém-Nascido , Recém-Nascido Prematuro , Hemorragias Intracranianas/sangue , Hemorragias Intracranianas/etiologia , Leucomalácia Periventricular/sangue , Leucomalácia Periventricular/etiologia , PrognósticoRESUMO
The work includes a research of morphological and immune-histochemical specifics of baby rats' cerebral structures in the conditions of experimental hypoxia model and with the administration of Cerebrocurin. It was ascertained that the most pronounced changes in the form of pericellular and perivascular edema, spongiform loci and loci of necrosis, with the phenomena of apoptosis and aponeuroses, occurred during severe hypoxia. Administration of Cerebrocurin in baby rats, which experienced moderate hypoxia, causes a decrease in pathological changes in cerebral structures and the approximation of the level of CD95 APO-1/Fas and Bcl-21 gene expression to their level in intact animals.
Assuntos
Tronco Encefálico/patologia , Hipóxia/patologia , Neurônios/patologia , Fármacos Neuroprotetores/uso terapêutico , Animais , Animais Recém-Nascidos , Apoptose/efeitos dos fármacos , Encefalopatias/imunologia , Encefalopatias/metabolismo , Encefalopatias/patologia , Encefalopatias/prevenção & controle , Tronco Encefálico/efeitos dos fármacos , Tronco Encefálico/imunologia , Tronco Encefálico/metabolismo , Modelos Animais de Doenças , Expressão Gênica/efeitos dos fármacos , Hipóxia/imunologia , Hipóxia/metabolismo , Neurônios/imunologia , Neurônios/metabolismo , Fármacos Neuroprotetores/administração & dosagem , Fármacos Neuroprotetores/química , Proteínas Proto-Oncogênicas c-bcl-2/genética , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Ratos , Receptor fas/genética , Receptor fas/metabolismoRESUMO
The authors carried out the sudy on morphofunctional changes of mitochondria of neurocytes of the brainstem of rats under experimental model of hypoxia and administration of Cerebrokurin and lipin. Cerebrokurin administration to rats which underwent severe chronic hypoxia lead to increase in mitochondria diameter and considerable increase of their area in the unit of volume as well it resulted in renewal of myelin sheaths. Use of Cerebrokurin and lipin in animals which underwent moderate hypoxia lead to probable increase in mitochondria area in the unit of volume in comparison with animals not treated with these agents.
Assuntos
Aminoácidos/uso terapêutico , Encéfalo , Hipóxia Fetal/patologia , Mitocôndrias/efeitos dos fármacos , Peptídeos/uso terapêutico , Aminoácidos/administração & dosagem , Animais , Animais Recém-Nascidos , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Encéfalo/ultraestrutura , Misturas Complexas , Modelos Animais de Doenças , Quimioterapia Combinada , Metabolismo Energético/efeitos dos fármacos , Feminino , Microscopia Eletrônica de Transmissão , Mitocôndrias/metabolismo , Mitocôndrias/ultraestrutura , Tamanho Mitocondrial/efeitos dos fármacos , Compostos Orgânicos/administração & dosagem , Compostos Orgânicos/uso terapêutico , Peptídeos/administração & dosagem , Gravidez , RatosRESUMO
Overall, fifty newborn infants born to mothers with extragenital pathology (diabetes mellitus) were studied for the coagulative link of the homeostasis system as were 20 babies born to essentially healthy mothers. The studies were made by day 1 to 3 and 5 to 7 the babies' life. The conducted studies revealed signs of hypercoagulation presenting with activation of the external and internal route of hemostasis in those infants born to mothers with diabetes mellitus (DM). Toward the period of early neonatal adaptation shifts are still observable in the coagulating system at the expense of stimulation of the first phase of coagulation. The disclosed abnormalities in the coagulative link of the coagulating system in infants born to DM mothers pose a threat of development of thrombohaemorrhagic complications.
Assuntos
Coagulação Sanguínea , Hemorragia/sangue , Trombose/sangue , Adulto , Testes de Coagulação Sanguínea , Diabetes Mellitus/sangue , Suscetibilidade a Doenças/sangue , Feminino , Humanos , Recém-NascidoRESUMO
A study was made on the condition of lipid peroxidation and of the antioxident system of defence in 20 infants born to healthy mothers (control group), 12 babies born to mothers with diabetes mellitus, 15 infants born to mothers with neurocirculatory asthenia and 12 infants born to mothers with congenital heart diseases. In infants born to mothers with diabetes mellitus and cardiovascular pathology, the system of regulation was found to have gotten out of balance, the compensatory-and-adaptive reactions upset. Accumulation of peroxidic products and depletion of the antioxidant system of defence tended to be more readily seen in those babies born to mothers with diabetes mellitus. The results secured attest to the need for employment of drugs endowed with antioxidant activity.