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1.
Sci Rep ; 12(1): 8635, 2022 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-35606380

RESUMO

As a powerful, non-destructive analysis tool based on thermal neutron capture reaction, prompt gamma neutron activation analysis (PGNAA) indeed requires the appropriate neutron source. Neutrons produced by electron Linac-based neutron sources should be thermalized to be appropriate for PGNAA. As a result, thermalization devices (TDs) are used for the usual fast neutron beam to simultaneously maximize the thermal neutron flux and minimize the non- thermal neutron flux at the beam port of TD. To achieve the desired thermal neutron flux, the optimized geometry of TD including the proper materials for moderators and collimator, as well as the optimized dimensions are required. In this context, TD optimization using only Monte Carlo approaches such as MCNP is a multi-parameter problem and time-consuming task. In this work, multilayer perceptron (MLP) neural network has been applied in combination with Q-learning algorithm to optimize the geometry of TD containing collimator and two moderators. Using MLP, both thickness and diameter of the collimator at the beam port of TD have first been optimized for different input electron energies of Linac as well as for moderators' thickness values and the collimator. Then, the MLP has been learned by the thermal and non-thermal neutron flux simultaneously at the beam port of TD calculated by MCNPX2.6 code. After selecting the optimized geometry of the collimator, a combination of Q-learning algorithm and MLP artificial neural network have been used to find the optimal moderators' thickness for different input electron energies of Linac. Results verify that the final optimum setup can be obtained based on the prepared dataset in a considerably smaller number of simulations compared to conventional calculation methods as implemented in MCNP.

2.
Appl Radiat Isot ; 118: 149-153, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27640175

RESUMO

An electron linear accelerator (Linac) can be used for boron neutron capture therapy (BNCT) by producing thermal neutron flux. In this study, we used a Varian 2300 C/D Linac and MCNPX.2.6.0 code to simulate an electron-photoneutron source for use in BNCT. In order to decelerate the produced fast neutrons from the photoneutron source, which optimize the thermal neutron flux, a beam-shaping assembly (BSA) was simulated. After simulations, a thermal neutron flux with sharp peak at the beam exit was obtained in the order of 3.09×108n/cm2 s and 6.19×108n/cm2 s for uranium and enriched uranium (10%) as electron-photoneutron sources respectively. Also, in-phantom dose analysis indicates that the simulated thermal neutron beam can be used for treatment of shallow skin melanoma in time of about 85.4 and 43.6min for uranium and enriched uranium (10%) respectively.


Assuntos
Terapia por Captura de Nêutron de Boro/instrumentação , Desenho Assistido por Computador , Elétrons/uso terapêutico , Nêutrons/uso terapêutico , Aceleradores de Partículas/instrumentação , Planejamento da Radioterapia Assistida por Computador/métodos , Neoplasias Cutâneas/radioterapia , Desenho de Equipamento , Análise de Falha de Equipamento , Humanos , Melanoma/patologia , Melanoma/radioterapia , Neoplasias Cutâneas/patologia , Resultado do Tratamento
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