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Nucleosides Nucleotides Nucleic Acids
; 34(11): 763-85, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26398773
RESUMO
Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.