1.
J Virol
; 88(4): 2333-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24307584
RESUMO
The discovery that RNA viruses, lacking any DNA intermediate, can be engineered to express both coding and noncoding RNAs suggests that this platform may have therapeutic value as a delivery vehicle. Here we illustrate that a self-replicating, noninfectious RNA, modeled on influenza virus, provides one such example of a versatile in vivo delivery system for silencing and/or expressing a desired RNA for therapeutic purposes.