[Organisation of medical care to military personnel with viral hepatitis. A during the local armed conflicts].

Organisation of medical care to military personnel with viral hepatitis A during the local armed conflicts. The article provides an analysis of medical care organisation system to patients with viral hepatitis A during conducting counterterror operations on the North Caucasus (1994-1996 and 1999-2002). The authors provided information on the main problems of medical support in modern local armed conflicts and shortcomings of organization of medical care to patients with viral hepatitis A in the following conditions: multistage, discrepancy between calculation of forces and facilities and character of military conditions, shortcoming of staff structure of medicalfacilities, inappropriate level ofproficiency ofphysicians of infectious profile and absence of regulations, concerning the use for equipment of infectious hospitals. 'Possible -ways for resolving these problems are showed.

[The treatment of acute intestinal diarrheal infections]. / Lechenie ostrykh kishechnykh diareinykh infektsii.

The article presents a short characteristic of the general therapeutic principles in intestinal diarrheal infections, the main of which are the following: early beginning, individual approach and complex therapy. Therapeutic schemes of the most frequent diseases are given. Special attention is paid to the great importance of rational bacterio-therapy in current treatment of acute intestinal diarrheal infections. Individual approach considers determination or supposition of disease etiology and clinical form before treatment, as well as evaluation of state pathogenesis taking into account the body physiologic specificity, severity and period of disease, possible complications and concomitant disease. Complex therapy supposes simultaneous effect on disease agent, several links of its pathogenesis, struggle with intoxication, restoration of the disturbed functions of organs and systems, increase in body defense, treatment of concomitant diseases.

[Emergency care for infectious disease patients]. / Neotlozhnaia pomoshch' infektsionnym bol'nym.

Urgent critical condition during acute course of infectious diseases can be developed in early terms and suddenly with fast irreversible changes in vital organs and systems. In connection with generality of pathogenesis of many groups of infectious diseases the critical conditions characterized by stereotyped clinical syndromes. They include infective toxic shock, infective toxic encephalopathy and cerebral hypertension, acute dehydration, acute respiratory, cardiac, hepatic, adrenal and renal insufficiency. Urgent therapeutic measures can be standardized with reference to that or other syndromes of critical conditions. In their number--prescription of glucocorticosteroids, diuretics, neuroleptics, antipyretic preparations, solutions of various applicability. Application of antimicrobic preparations and specific antitoxic serums, antimalarial preparations requires care in connection with possible development of complications of toxic or allergic character.

[Effect of inducers and inhibitors of mixed function oxidases on body resistance to endotoxins of gram-negative bacteria]. / Vliianie induktorov i ingibitorov oksidaz smeshannoi funktsii na rezistentnost' organizma k éndotoksinam gramotritsatel'nykh bakterii.

Experimental typhoid intoxication in white mice leads to the inhibition of microsomal oxidation in the liver, which is manifested by the prolongation of hexenal-induced sleep and a decrease in the toxic action of parathion. Phenobarbital, capable of inducing oxidases with mixed function (OMF), enhances the process of the detoxification of endotoxin injected into the animals, which is manifested by the increase of its LD50. Soluble levomycetin succinate, widely used for the treatment of typhoid-paratyphoid infections, is a powerful inhibitor of OMF (as shown by the hexenal test). Benzonal, the analog of phenobarbital, removes the inhibitory effect of the antibiotic. Experimental studies carried out in the course of this investigation make it possible to substantiate the clinical trial of these preparations (OMF inducers) used in the complex therapy of typhoid-paratyphoid infections for the stimulation of natural detoxification mechanisms of the body. Benzonal is the preparation of choice for use in clinical practice.