[Therapy of rapid ejaculation using dietary supplement "NeyroDoz": results of a multicenter non-randomized clinical study].

The main aim of the study was to determine the effectiveness of a multicomponent dietary supplement NeyroDoz in patients with rapid ejaculation. We examined 50 patients with rapid ejaculation (premature ejaculation), who were recruited in 9 clinical centers in different regions of Russia. These patients received NeyroDoz, 2 capsules twice a day for one month, followed by a control observation for 1 month. In study group of patients, symptomatic improvement was achieved in 45 (90%) of 50 patients at 4-week observation target date. In assessing the impact of NeyroDoz on different groups of symptoms, it was found that it significantly increases the average time of sexual intercourse by 2 times, increases the orgasm brightness, reduces the severity of psychosomatic component and has a positive effect on all components of the copulative cycle. In assessing the afterimpression, this effect was maintained throughout the period of follow-up.

[The use of ProstaDoz in patients with chronic prostatitis. Results ofa multicenter nonrandomized clinical study].

The main purpose of the study was to determine the effectiveness of a multicomponent dietary supplement ProstaDoz in patients with chronic prostatitis. The study included 50 men with clinical symptoms of a chronic prostatitis, which were observed in 9 clinical centers in different regions of Russia. All patients have received 2 capsules of ProstaDoz twice a day for 1 month, followed by dynamic observation for 4 weeks. Symptomatic improvement was achieved in 46 (92%) patients. Evaluation of effects of ProstaDoz on various groups of symptoms has revealed that it reduces pain, promotes urination normalization and improvement of quality of life. These effects were maintained during all follow-up period.

[Efficacy of vitaprost forte in the treatment of prostatic adenoma].

Thirty patients with a documented diagnosis of prostatic adenoma were treated with vitaprost forte (100 mg rectal suppositoria) for 60 days. Treatment efficacy was assessed after therapy and for two months with a 30-day interval. It is shown that the drug can be used as monotherapy. Its efficacy was proved by improved urodynamics of the lower urinary tract, reduction of prostatic size. A therapeutic effect after the drug discontinuation points to a complex organotropic action of the drug. Side effects were not registered. Vitaprost forte is recommended for treatment of patients suffering from prostatic adenoma with mild and moderate symptoms.

[Prevention and treatment of complications in patients after cystectomy with enterocystoplasty].

Surgical outcomes have been analysed for 211 patients with urinary bladder tumors. The operation consisted in cystectomy with one- or multistage creation of intestinal neocystis. Causes of early and late postoperative complications were studied. Original surgical techniques with creation of orthotopic intestinal bladder preventing complications of cystectomy are proposed.

[Choice of a method of surgical treatment of urinary bladder neoplasms]. / Vybor metoda operativnoogo lecheniia novoobrazovanii mochevogo puzyria.

The results of treatment of 850 patients with urinary bladder cancer (UBC) are analysed. Precise staging of the tumor should be made in the following order: suprapubic ultrasonic investigation (USI), cystoscopy and microcystoscopy, transrectal, transurethral USI. Indications for different treatments are outlined: typical and atypical papillary fibroepithelioma, papillary cancer in stage T1 should be managed with TUR after previous electrocoagulation; cancer in stage T2-3--with urinary bladder resection and uni- or bilateral pelvic lymphadenectomy; total papillomatosis, multiple lesions in stage T3, in cases of recurrent cancer--with cystectomy including one-stage or multistage replacement of the urinary bladder by intestinal transplant. The only physiologically sound method of treating patients after cystectomy with ureterocutaneostomy and ureterocolostomy is creation of intraperitoneal intestinal urinary bladder with reestablishment of transurethral urination. Arguments against creation of artificial urinary bladder made of detubularized segments consist in the absence of advantages.

[The formation of an artificial bladder from the intestines]. / Formirovanie artifitsial'nogo kishechnogo mochevogo puzyria.

Basing on the long-term experience in radical surgery of 252 patients with invasive bladder cancer, the authors come to the conclusion that the establishment of intestinal bladder with postcystectomy recovery of physiological uresis is the most proper therapeutic approach. Extra- or intraperitoneal position of the transplant was decided upon regarding the type and stage of cystectomy and prior methods of derivation. The techniques of one- and multistage operations are presented. Clinical practice evidences that more rapid recovery of urethral uresis can be obtained with application of primary continuous suture of artificial intestinal bladder (ideal enterocystoplasty) at the end of the surgery. Urodynamic low urinary tract findings are provided. The technique developed by the authors offers new surgical opportunity for bladder cancer patients following cystectomy.