Ureaplasma urealyticum osteomyelitis in a very low birth weight infant.

We are reporting on a very low birth weight male infant with osteomyelitis of the right femur during blood stream infection with Ureaplasma urealyticum. After previously recognized pulmonary and central nervous system infections, our case description link U. urealyticum to bone disease, widening the spectrum of pathologic conditions in neonates due to this agents.

Ureaplasma urealyticum infection in newborns: three case reports.

We report three newborns with different manifestations of Ureaplasma urealyticum infection; a term newborn with acute neonatal pneumonia and two very low birth weight infants with bronchopulmonary dysplasia and osteomyelitis of the femur, respectively. The association of U. urealyticum with acute and chronic respiratory disease in term and preterm newborns has recently been reported. Our two cases are similar to other case reports from the literature, but we were unable to find any previous reports of osteomyelitis due to U. urealyticum in the premature babies. Isolation of U. urealyticum in pure culture from the blood was considered to be related to local infection in all three patients. All patients were cured by erythromycin.

[Hemorrhagic disease of the newborn]. / Hemoragijska bolest novorodenceta.

The authors present 16 patients with the idiopathic forms of hemorrhagic disease in newborns, none of which, after birth, having prophylactically received K-vitamin. Seven of them had an early form, four a classical form, and five a late form of hemorrhagic disease. All of them were born at term, four were female and 12 male newborns. The diagnosis was established on the basis of the decreased prothrombin time (PV) and the activated partial thromboplastin time (APTV), as well as their normalization following the applied therapy. The PV values in these patients ranged from 0.009 to 0.65 and the APTV from 33 to 120. The authors point out the significance of the prophylaxis of hemorrhagic diseases in the newborn and the still inconclusive state of scientific dilemmas and clinical practice in this connection.

[The amazing neonate]. / Cudesno novorodence.

According to a questionnaire including 78 general practitioners, specialists in pediatrics and obstetrics, physicians specializing pediatrics and obstetrics, and 43 students of a High Nursing School, 21.8% of physicians and 58% of nurses think that the newborn does not see, 17.9% of physicians and 18.6% of nurses think that the newborn does not hear, and 44.9% of physicians and 79.1% of nurses think that the newborn has no feeling of the position of the body in space and of its movements. The existence of the sense of smell in the newborn is denied by 66.7% of physicians and 55.8% of nurses, and of the sense of taste by 44.9% of physicians and 41.9% of nurses. All the nurses know that the newborn has the sense of touch, while 3.8% of physicians think the opposite. Two thirds of those included in the questionnaire think that the newborn can memorize and the three quarters of them think it can learn. Much fewer nurses than physicians (32.4%:61%) consider the newborn a passive receiver of external stimuli. As many as 97% of physicians think that an early stimulation of the newborn helps its psychomotor development and a high percentage of them positively assess the majority of measures implementing it. Yet, only 66.7% of physicians consider it necessary for parents to be near the hospitalized premature infant, while 24.4% of all the questioned do not consider the prevention of the birth of undesirable children a measure by which the quality of the parent-child relation could be influenced.

[Massive adrenal hemorrhage in a neonate due to neuroblastoma]. / Masivna adrenalna hemoragija u novorodenceta uzrokovana neuroblastomom.

A newborn with symptoms of massive adrenal hemorrhage is presented. The cause was a unilateral neuroblastoma of the adrenal gland, bringing about severe anemia and hemorrhagic shock. The suspicion of a tumor of the adrenal gland was confirmed by infusion urography, ultrasound examination of the kidney, and the increased amount of vanillymandelic acid in the urine. Nephrectomy was performed on the fourth day of the newborn's life. The tumour was classified in the IV-S stage after Evans et al. Following the operation, neither cytostatics nor radiation was applied. The child is developing normally and the amount of vanillymandelic acid in the urine is within normal limits. The child is now in the 16th month of life.

A liver urocanase deficiency.

Two sisters with a rare inborn error of histidine metabolism resulting from urocanase deficiency are being presented. The more common form of familial histidinemia due to histidase deficiency is excluded. The urocanase deficiency is proven by demonstrating increased excretion of metabolites of the product of the urocanase enzyme action. Further, the strongest evidence for the urocanase defect rests on the demonstration of urocanase deficiency and normal histidase activity in liver.