Tubo-ovarian abscess during therapy of chronic hepatitis C with pegylated interferon and ribavirin.

BACKGROUND: Serious infections are rare complications of standard treatment in chronic hepatitis C with pegylated interferon alpha (Peg IFN) and ribavirin. CASE: We report two cases of life-threatening tubo-ovarian abscess (TOA) in women older than 40 year of age. No casual risk factors of TOA could be identified in them. In one case septic shock and acute renal failure occured. TOA was caused by endogenic bacteria (Porphyromonas asaccharolytica in the first case and Streptococcus intermedius in the latter). Surgical treatment and interruption of IFN therapy was necessary in both cases. CONCLUSIONS: Serious gynecological infections may have the significant negative influence on chronic hepatitis C therapy outcome. Because of the risk of TOA developing during IFN therapy gynecological care is needed in chronic hepatitis C management.

Structural, spectral, and magnetic properties of end-to-end di-mu-thiocyanato-bridged polymeric complexes of Ni(II) and Co(II). X-ray crystal structure of di-mu-thiocyanatobis(imidazole)nickel(II).

Thiocyanatonickel(II) and thiocyanatocobalt(II) complexes of the composition Ni(NCS)(2)(HIm)(2) (1) and Co(NCS)(2)(HIm)(2) (2), where HIm = imidazole, were prepared and studied. In particular, the crystal structure of Ni(NCS)(2)(HIm)(2) was determined by X-ray methods. This compound crystallizes in the monoclinic system, space group P2(1)/n, with a = 7.720(1) A, b = 5.557(1) A, c = 13.774(3) A, beta = 102.54(3) degrees, and Z = 2. Its structure consists of a one-dimensional polymeric chain in which nickel(II) ions are bridged by two thiocyanate groups bonding in an end-to-end fashion in a trans arrangement. The Ni...Ni distance is 5.557(1) A. The crystal packing is determined by the intermolecular hydrogen bonds and ring-stacking interactions. From their X-ray powder-diffraction patterns and IR spectra, the complexes 1 and 2 were found to be mutually isomorphous. The coordination compounds were identified and characterized using elemental analysis, magnetic measurements, and infrared and ligand-field spectra. Both complexes are first examples of ferromagnetically coupled one-dimensional polymeric compounds with double end-to-end thiocyanate bridges. The magnetic properties of the title compounds were investigated over the 1.9-290 K temperature range. The compounds exhibit long-range magnetic ordering with T(c) equal to 5.0 and 5.5 K for 1 and 2, respectively. Their isothermal magnetization was also studied. The magnetostructural properties of the nickel(II) compound obtained are discussed and compared to those of other double end-to-end thiocyanate-bridged nickel(II) complexes.