Association between Polyphenol Intake and Lipid Profile of Adults and Elders in a Northeastern Brazilian Capital.

This research was aimed at evaluating the relationship between the estimated polyphenol intake and the atherogenic lipid profile in adult and elder residents in the city of Teresina, located in the Northeastern Region of Brazil. This study was a cross-sectional population-based survey with 501 adults and elders, conducted in Teresina, Brazil. Food intake was obtained by 24-h food recall. The estimated polyphenol intake was calculated by multiplying the food consumption data from the recall by the polyphenol content in the foods described in the Phenol-Explorer database. The mean intake of total polyphenols was 1006.53 mg/day. The phenolic acids was the class with the highest intake, followed by the flavonols. Coffee, beans and apples were the main foods contributing to the total polyphenol intake. In the individuals with elevated serum concentrations of total cholesterol and triglycerides, the intake of total polyphenols was significantly higher. The intake of total polyphenols, phenolic acids and lignans was higher in the subjects with dyslipidemia. This article provides, for the first time, data on the intake of the total polyphenol classes and subclasses in the evaluated population and the relationship with the lipid profile. The individuals with a higher intake of total polyphenols had a worse lipid profile, which may be a consequence of an improved diet in those individuals who present with dyslipidemia.

Association between Consumption of Ultra-Processed Food and Body Composition of Adults in a Capital City of a Brazilian Region.

The present study investigates the relationship between the consumption of ultra-processed foods (UPF) and anthropometric indices of body composition in adults and seniors living in Teresina, the state capital of an area in northeastern Brazil. The article seeks to address two questions: Is UPF consumption linked to worsening body composition in different age groups? Do anthropometric indicators of body composition change with the increasing consumption of UPF? The study is a cross-sectional, household, population study, carried out with 490 adults and seniors. The food consumption was obtained with a 24 h food recall, and the foods were classified using NOVA. Anthropometric indicators evaluated were waist-to-height ratio, triceps skinfold thickness, arm circumference, corrected arm muscle area, subscapular skinfold thickness, and calf circumference. The association between energy contribution of UPF with anthropometric indicators was verified with a simple and multiple linear regression analysis. Individuals aged 20 to 35 years showed a significant association between UPF consumption and skinfold thickness (ß: 0.04; CI: 0.03/0.09), demonstrating an increase in this subcutaneous body fat marker with higher UPF consumption. Moreover, in participants aged 36 to 59 years, an inverse correlation between UPF intake and muscle mass markers, arm circumference (ß: -0.02; confidence interval: -0.03/-0.01), and corrected arm muscle area (ß: -0.07; confidence interval: -0.12/-0.02) were observed. Such results suggest there is decreased muscle mass with increasing UPF consumption. This is the first study that verified an association between UPF consumption and low-cost body composition indicators in different age groups.

Sensibilidade, especificidade e eficiência dos indicadores do estado nutricional de idosos atendidos pela Estratégia de Saúde da Família / Sensitivity, specificity and efficiency of indicators of the nutritional status of the elderly attended by the Family Health Strategy

Objetivo: Averiguar a sensibilidade, especificidade e eficiência dos indicadores do estado nutricional de idosos. Métodos: Trata-se de uma pesquisa descritiva, transversal, com uma abordagem quantitativa. Foram avaliados 252 idosos assistidos por equipe da Estratégia Saúde da Família. O estado nutricional dos idosos foi avaliado a partir dos indicadores antropométricos Índice de Massa Corporal (IMC), Circunferência da Panturrilha (CP), Dobra Cutânea Tricipital (DCT), Área Muscular do Braço (AMB) e Circunferência Muscular do Braço (CMB) e da Mini Avaliação do Estado Nutricional (MAN). O índice kappa foi utilizado para avaliar a concordância entre os métodos de avaliação do estado nutricional de idosos, com nível de significância estabelecido em p < 0,05. Resultados: Em relação ao estado de desnutrição, destacou-se a comparação do IMC vs. CMB (sensibilidade S =100%, valor preditivo negativo VPN = 100%, p = 0,001). O estado de eutrofia foi determinado utilizando os indicadores IMC vs. MAN (S = 84,4%, VPN = 71,1%, p = 0,04), bem como a do IMC vs. CMB (especificidade = 95,8%, VPN = 56%, p = 0,02). O intuito foi diagnosticar o estado de obesidade entre idosos, em relação aos indicadores IMC vs DCT, (especificidade = 82,8%, VPN= 70,2%, p= 0.06). Conclusão: Existe uma boa associação entre os indicadores, para determinar o estado nutricional de idosos atendidos pela Estratégia Saúde da Família, quanto a sensibilidade e especificidade dos métodos de avaliação. (AU)

Objective: To determine the sensitivity, specificity and efficiency indicators of the nutritional status of the elderly. Methods: This is a descriptive, cross-sectional research with a quantitative approach. We evaluated 252 elderly assisted by the Family Health Strategy team. The nutritional status of the elderly was evaluated based on anthropometric indicators: Body Mass Index (BMI), Circumference Calf (CP), Triceps Skin Fold (TSF), Arm Muscle Area (AMA) and Circumference Muscular Arm (CMA) and Mini nutritional assessment (MNA). The kappa index was used to evaluate the correlation between the methods of evaluating the nutritional status of the elderly, with a significance level set at p < 0.05. Results: In relation to the state of malnutrition we highlighted the comparison of BMI vs. CMA (S = 100% sensitivity, negative predictive value NPV = 100%, p = 0.001). We evaluated the state of normal weight using BMI vs. MNA indicators (S = 84.4% NPV = 71.1%, p = 0.04), as well as BMI vs. CMA (Specificity = 95.8% NPV = 56%, p = 0.02). The aim was to diagnose the state of obesity among the elderly in relation to BMI indicators vs. TSF (Specificity = 82.8%, NPV = 70.2%, p = 0.06). Conclusion: There is a good association between the indicators to determine the nutritional status of the elderly assisted by the Family Health Strategy, regarding the sensitivity and specificity of the evaluation methods. (AU)

Ferulic acid ethyl ester diminished Complete Freund's Adjuvant-induced incapacitation through antioxidant and anti-inflammatory activity.

Ferulic acid ethyl ester (FAEE) is a derivate from ferulic acid which reportedly has antioxidant effect; however, its role on inflammation was unknown. In this study, we investigated the orally administered FAEE anti-inflammatory activity on experimental inflammation models and Complete Freund's Adjuvant (CFA)-induced arthritis in rats. CFA-induced arthritis has been evaluated by incapacitation model and radiographic knee joint records at different observation time. FAEE (po) reduced carrageenan-induced paw edema (p < 0.001) within the 1st to 5th hours at 50 and 100 mg/kg doses. FAEE 50 and 100 mg/kg, po inhibited leukocyte migration into air pouch model (p < 0.001), and myeloperoxidase, superoxide dismutase, and catalase activities (p < 0.001) increased total thiol concentration and decreased the TNF-α and IL-1ß concentrations, NO, and thiobarbituric acid reactive species. In the CFA-induced arthritis, FAEE 50 and 100 mg/kg significantly reduced the edema and the elevation paw time, a joint disability parameter, since second hour after arthritis induction (p < 0.001). FAEE presented rat joint protective activity in radiographic records (p < 0.001). The data suggest that the FAEE exerts anti-inflammatory activity by inhibiting leukocyte migration, oxidative stress reduction, and pro-inflammatory cytokines.

IN VITRO AND IN VIVO ANTIOXIDANT ACTIVITY OF BURITI FRUIT (MAURITIA FLEXUOSA L.F.).

INTRODUCTION: studies have shown high concentration of monounsaturated fatty acids, carotenoids, polyphenols and ascorbic acid in Buriti fruit (Mauritia flexuosa L.f.). This study evaluated the in vitro and in vivo antioxidant activities of buriti fruit (Mauritia flexuosa L.f.). METHODS: the chemical composition and total phenolic and carotenoid contents of the buriti pulp and the feed rations were determined, and the in vitro antioxidant activity was analyzed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay. Wistar rats (21 days old) were randomly allocated (n=10) into a control groups and experimental groups (feed enriched with buriti pulp). After 60 days, the in vivo antioxidant activity was evaluated through the determination of the catalase activity and non-protein sulfhydryl (NPSH) groups in the liver and quantification of malondialdehyde (MDA) in the plasma and tissues. RESULTS: high contents of oleic fatty acids (73.3%), phenolic compounds (192 ± 0.3 mg/100 g) and carotenoids (23.9 ± 0.5 mg/100 g) as well as elevated in vitro antioxidant activity were found in the buriti pulp. The enriched diet had higher contents of phenols and carotenoids as well as higher antioxidant activity compared with the standard feed (p < 0.05). There were no differences between the groups regarding catalase activity in the liver and MDA concentrations in the plasma, liver and kidneys. The male rats of the experimental group had higher liver concentrations of NPSH compounds (p < 0.05). CONCLUSION: these results may corroborate the claim that buriti fruit is an antioxidant functional food and support its utilization in a nutritionally balanced diet.

Introducción: estudios previos han demostrado que la fruta Burití (Mauritia flexuosa L.f). posee una alta concentración de ácidos grasos monoinsaturados, carotenoides, polifenoles y ácido ascórbico. Este estudio evaluó la actividad antioxidante in vitro e in vivo del Burití. Métodos: fueron determinadas la composición química, el contenido de compuestos fenólicos y de carotenoides tanto de la pulpa del Burití como de las raciones de alimento. La actividad antioxidante in vitro fue analizada utilizando el ensayo del radical 2,2-difenil-1-picrilhidrazil (DPPH). Ratas Wistar (21 días de edad) fueron asignadas al azar (n = 10) en grupos controles y grupos experimentales (alimentación enriquecida con pulpa de Burití). Después de 60 días, la actividad antioxidante in vivo se evaluó mediante la actividad enzimática de la catalasa y grupos sulfhidrílo no proteico (NPSH) en el hígado, y se cuantificó el malondialdehído (MDA) en plasma y tejidos. Resultados: la pulpa del Burití presentó alto contenido de ácido graso oleico (73,3%), compuestos fenólicos (192 ± 0,3 mg/100 g) y carotenoides (23,9 ± 0,5 mg/100 g), así como una elevada actividad antioxidante in vitro. La dieta enriquecida tenía mayor contenido de fenoles y carotenoides, y una mayor actividad antioxidante en comparación con la alimentación estándar (p < 0,05). No se observaron diferencias entre los grupos con respecto a la actividad de la catalasa en el hígado y las concentraciones de MDA en plasma, hígado y riñones. Las ratas macho del grupo experimental tuvieron concentraciones hepáticas más altas de NPSH (p < 0,05). Conclusión: estos resultados pueden corroborar la hipótesis de que la fruta Burití es un alimento funcional antioxidante y su consumo es conveniente en una dieta nutricionalmente equilibrada.

Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program.

INTRODUCTION: Albumin is considered an important extracellular antioxidant molecule. hypoalbuminemia is a strong and independent predictor of mortality in patients on hemodialysis. The present study evaluated the relation between hypoalbuminemia and oxidative stress by comparing superoxide dismutase activity, lipid peroxidation and antioxidant micronutrient consumption in chronic renal failure patients. METHODS: A case-control study was carried out with 64 patients of both sexes aged 18 to 59 years. The patients with hypoalbuminemia (ALB < 3,5 g/dL) were defined as case (n = 26) and control (n = 38) those with ALB ≥ 3.5 g/dL.Determinations of activity superoxide dismutase (SOD)and nitric oxide production by the contraction of nitrite in erythrocytes, concentration of malondialdehyde (MDA)in plasma, lipid profile and micronutrient antioxidants intake were performed. For comparisons between groups,the Student t test was used. Possible associations between variables were tested using the chi-square test and Pearson correlation test. RESULTS: Consumption of copper was significantly lower(p < 0.05) in the group with hypoalbuminemia. There was a positive correlation between the concentrations of albumin and intake copper (r = 0.280). Negative correlation was found between albumin and MDA concentrations. CONCLUSION: Hypoalbuminemia is associated with increased lipid peroxidation, and can contribute to oxidative stress in chronic renal failure patients. Additionally, patients with chronic renal disease undergoing hemodialysis evaluated in this study had reduced consumption of cooper.

Introducción: La albumina se considera una molecula antioxidante extracelular importante. La hipoalbuminemia es un predictor fuerte e independiente de mortalidad en pacientes en hemodialisis. El presente estudio evaluo la relacion entre hipoalbuminemia y el estres oxidativo mediante la comparacion de la actividad de la superoxido dismutasa, la peroxidacion lipidica y el consumo de micronutrientes antioxidantes en pacientes con insuficiencia renal cronica. Métodos: Este estudio de casos y controles se llevo a cabo con 64 pacientes de ambos sexos de 18 a 59 anos. Los pacientes con hipoalbuminemia (ALB < 3,5 g / dL) se definieron como los casos (n = 26) y el grupo control (n = 38) aquellos con ALB ≥ 3,5 g/dL. Fueran realizadas determinaciones de la actividad de la superoxido dismutasa en los eritrocitos, la produccion de oxido nitrico por la contraccion de nitrito e concentracion de malondialdehido (MDA) en plasma, el perfil de lipidos en plasma, la ingesta de proteinas y micronutrientes antioxidantes se realizaron. Para las comparaciones entre grupos, se utilizo la prueba t de Student. Posibles asociaciones entre variables se analizaron mediante el test de correlacion lineal y Pearson y en la prueba de chi-cuadrado. Resultados: El consumo de cobre fue significativamente menor (p < 0,05) para el grupo con hipoalbuminemia. Correlaciones entres las concentraciones de albumina y el uso de cobre (r = 0,280). Se encontro correlacion negativa entre las concentraciones de albumina y MDA. Conclusión: La hipoalbuminemia se asocia con aumento de la peroxidacion lipidica, y puede contribuir al estres oxidativo en pacientes con insuficiencia renal cronica. Ademas, los pacientes con enfermedad renal cronica sometidos a hemodialisis evaluados en este estudio habian reducido el consumo de cobre.