RESUMO
INTRODUCTION: Collagenous colitis (CC) is an uncommon disease with a favorable prognosis. It is included in the group of chronic watery diarrheas. OBJECTIVE: To study epidemiological and clinical characteristics of CC, as well as its course and response to the treatment. MATERIAL AND METHODS: This is a descriptive, retrospective study of the endoscopic colon biopsies performed in Hospital de León during 5 years. Those biopsies that fulfilled the histological criteria of CC were selected. RESULTS: A total of 18 cases with an incidence of 1.25/10(5) inhabitants/year was obtained. Mean age was 66.7 years. There was no difference between both genders. The period of time to diagnosis was long (10 months). A possible association with intake of some drugs, as non-steroidal antiinflammatory drugs (46%) and lansoprazole (42.8%), and smoking (41.6%), as well as autoimmune disease (30.7%) was found. There was a good response to the treatment with mesalazine in 2 of 3 patients who received this treatment. The clinical course was also favorable for the 2 patients treated with budesonide. CONCLUSION: It is important to take multiple biopsies of the colon in order to diagnose CC when there is a case of chronic watery diarrhea even when the colonoscopy is normal. Certain drugs and autoimmune diseases may be involved in the etiology.
Assuntos
Colite Colagenosa , Estudos Retrospectivos , Adulto , Idoso , Idoso de 80 Anos ou mais , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/uso terapêutico , Biópsia , Budesonida/administração & dosagem , Budesonida/uso terapêutico , Colite Colagenosa/diagnóstico , Colite Colagenosa/tratamento farmacológico , Colite Colagenosa/patologia , Colo/patologia , Colonoscopia , Diarreia/diagnóstico , Diarreia/etiologia , Feminino , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Masculino , Mesalamina/administração & dosagem , Mesalamina/uso terapêutico , Pessoa de Meia-Idade , Fatores de Tempo , Resultado do TratamentoAssuntos
Adjuvantes Imunológicos/efeitos adversos , Vacina BCG/efeitos adversos , Mycobacterium bovis , Tuberculose/etiologia , Adjuvantes Imunológicos/administração & dosagem , Administração Intravesical , Idoso , Vacina BCG/administração & dosagem , Carcinoma de Células de Transição/tratamento farmacológico , Humanos , Masculino , Neoplasias da Bexiga Urinária/tratamento farmacológicoRESUMO
Two cases of tenosynovitis tuberculosa are presented. It was the only tuberculosis manifestation in one of them. The other showed a normal chest X-ray but epithelioid granulomas were found in the bone marrow examination which forced a differential diagnosis to be made of multiple myeloma. The combined therapy, surgery + drug regimen for tuberculosis produced a good evolution.