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Acta Trop ; 152: 56-59, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26314230

RESUMO

The human Pegivirus (HPgV, also known as GBV-C virus or hepatitis G virus) is a lymphotropic RNA-virus phylogenetically related to the Hepatitis C virus, which infects approximately 5% of the world's human population. Recently, two novel, presumably hepatotropic, pegiviruses, designated as equine Pegivirus (EPgV) and Theiler's Disease Associated Virus (TDAV), were discovered in horses with clinical and laboratory evidence of hepatic disease. To verify the occurrence of pegiviruses infection in horses from Pará State, northern Brazil, serum samples from 114 horses located in four cities (Acará, Belém, Dom Eliseu and Ananindeua) were submitted for the molecular analysis of EPgV by nested RT-PCR. The results of nucleotide sequencing and phylogenetic analysis of EPgV NS3 and NS5B genomic regions confirmed one positive sample among 114 tested samples (1/114; 0.8%). No evidence of TDAV infection was found, but despite the low prevalence and unknown clinical significance among the studied population, these results represent the first molecular detection of EPgV in horses in South America.


Assuntos
Sangue/virologia , Infecções por Flaviviridae/epidemiologia , Infecções por Flaviviridae/veterinária , Flaviviridae/genética , Flaviviridae/isolamento & purificação , Doenças dos Cavalos/virologia , Animais , Sequência de Bases , Brasil/epidemiologia , Feminino , Cavalos , Humanos , Filogenia , Prevalência
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