RESUMO
BACKGROUND: In times of coronavirus, a patient with respiratory symptoms whose chest CT scan reveals ground-glass opacities, COVID-19 may seem an obvious diagnosis. CASE DESCRIPTION: At the (currently assumed) peak of the coronavirus crisis, a 12-year-old boy was admitted to the hospital twice for severe respiratory symptoms. A chest CT scan revealed ground-glass opacities.COVID-19 pneumonia was initially thought of. However, it turned out to be a rare interstitial pulmonary disease. CONCLUSION: Due to the increased awareness about COVID-19, tunnel vision is lurking. Even during a health crisis, doctors should remain alert to alternative diagnoses.
Assuntos
COVID-19/diagnóstico , Doenças Pulmonares Intersticiais/diagnóstico , Pulmão , COVID-19/epidemiologia , COVID-19/fisiopatologia , COVID-19/psicologia , Teste para COVID-19 , Criança , Tomada de Decisão Clínica , Diagnóstico Diferencial , Humanos , Julgamento , Pulmão/diagnóstico por imagem , Pulmão/fisiopatologia , Doenças Pulmonares Intersticiais/fisiopatologia , Masculino , SARS-CoV-2 , Avaliação de Sintomas/métodos , Tomografia Computadorizada por Raios X/métodosRESUMO
OBJECTIVE: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD). DESIGN: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC). SETTING: University hospital. PATIENT(S): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC. INTERVENTION(S): PGD. MAIN OUTCOME MEASURE(S): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones. RESULT(S): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems. CONCLUSION(S): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. TRIAL REGISTRATION NUMBER: NCT02149485.