RESUMO
The objective of this study was to determine the surface contamination with platinum-containing antineoplastic drugs in veterinary and human oncology centres. Inductively coupled plasma mass spectrometry was used to measure platinum levels in surface samples. In veterinary and human oncology centres, 46.3 and 68.9% of the sampled surfaces demonstrated platinum contamination, respectively. Highest platinum levels were found in the preparation rooms (44.6 pg cm(-2)) in veterinary centres, while maximal levels in human centres were found in oncology patient-only toilets (725 pg cm(-2)). Transference of platinum by workers outside areas where antineoplastic drugs were handled was observed in veterinary and human oncology centres. In conclusion, only low levels of platinum contamination attributable to carboplatin were found in the sampled veterinary oncology centres. However, dispersion of platinum outside areas where antineoplastic drugs were handled was detected in veterinary and human oncology centres. Consequently, not only personnel, but also others may be exposed to platinum.
Assuntos
Antineoplásicos/análise , Carboplatina/análise , Monitoramento Ambiental/métodos , Espectrometria de Massas/métodos , Exposição Ocupacional/análise , Platina/análise , Animais , Institutos de Câncer , Contaminação de Equipamentos , Humanos , Espectrometria de Massas/veterinária , Países BaixosRESUMO
Residues of antineoplastic drugs in canine excretion products may represent exposure risks to veterinary personnel, owners of pet dogs and other animal care-takers. The aim of this study was to measure the extent and duration of platinum (Pt) excretion in pet dogs treated with carboplatin. Samples were collected before and up to 21 days after administration of carboplatin. We used validated, ultra-sensitive, inductively coupled plasma-mass spectrometry assays to measure Pt in canine urine, faeces, saliva, sebum and cerumen. Results showed that urine is the major route of elimination of Pt in dogs. In addition, excretion occurs via faeces and saliva, with the highest amounts eliminated during the first 5 days. The amount of excreted Pt decreased over time but was still quantifiable at 21 days after administration of carboplatin. In conclusion, increased Pt levels were found in all measured excretion products up to 21 days after administration of carboplatin to pet dogs, with urine as the main route of excretion. These findings may be used to further adapt current veterinary guidelines on safe handling of antineoplastic drugs and treated animals.
Assuntos
Antineoplásicos/uso terapêutico , Carboplatina/uso terapêutico , Doenças do Cão/tratamento farmacológico , Neoplasias/veterinária , Platina/análise , Espectrofotometria Atômica/veterinária , Animais , Antineoplásicos/administração & dosagem , Antineoplásicos/química , Antineoplásicos/farmacocinética , Carboplatina/administração & dosagem , Carboplatina/química , Carboplatina/farmacocinética , Cerume/química , Doenças do Cão/metabolismo , Cães , Relação Dose-Resposta a Droga , Fezes/química , Neoplasias/tratamento farmacológico , Platina/química , Platina/urina , Saliva/química , Sebo/químicaRESUMO
BACKGROUND: Peri-articular histiocytic sarcoma (PAHS) occurs in dogs, including Bernese Mountain Dogs (BMD). An etiologic relationship with previous joint disease has not been documented. HYPOTHESIS: Peri-articular histiocytic sarcoma in BMD will be more frequently encountered around previously diseased joints compared with normal joints. ANIMALS: 920 European BMD. METHODS: A retrospective study, in which data were obtained through an Internet questionnaire and from 2 veterinary pathology laboratories. Archived samples of hematoxylin-eosin (H&E) staining diagnosed PAHS and synovial cell sarcoma (SCS) were immunolabeled with CD18 and pancytokeratin. Descriptive, comparative, and actuarial statistics comprise the data analysis. RESULTS: All primary synovial tumors were identified as PAHS based on their morphology, positive CD18, and negative pancytokeratin labeling. Joint disease was diagnosed in 226 BMD, of which 15 developed PAHS in a previously diseased joint and 3 in a nondiseased joint. Of the remaining 694 BMD without joint disease, 9 developed PAHS. The odds ratio for a dog with previous joint disease developing PAHS is calculated as 5.4 (95% CI: 2.3-12.5; P < .0001) compared with no previous joint problem. A significant association between previous joint disease and PAHS in the same joint was demonstrated for the left elbow (P = .016), right elbow (P = .006), right shoulder (P = .047), left and right stifle (P < .001), and left carpal joint (P = .010). CONCLUSIONS AND CLINICAL IMPORTANCE: The results of this study suggest a relation between previous joint disease and the development of PAHS in the same joint of European BMD. Owners of BMD should monitor dogs for peri-articular swellings, particularly around previously diseased joints.
Assuntos
Doenças do Cão/patologia , Sarcoma Histiocítico/veterinária , Cápsula Articular/patologia , Artropatias/veterinária , Animais , Distribuição de Qui-Quadrado , Cães , Feminino , Sarcoma Histiocítico/etiologia , Sarcoma Histiocítico/patologia , Histocitoquímica/veterinária , Artropatias/patologia , Masculino , Estudos RetrospectivosRESUMO
In preparing this document the Authors aimed to pool current information on canine and feline mast cell disease. The information was gathered from international studies and a emphasis was placed on material and opinion with a strong evidence base. We intend it to form the basis of our understanding in this disease at the current time and we anticipate that it will be particularly useful for the general practitioner. It should be emphasized that the authors are presenting this work from a European perspective.
Assuntos
Doenças do Gato/diagnóstico , Doenças do Cão/diagnóstico , Mastocitose/veterinária , Animais , Doenças do Gato/patologia , Doenças do Gato/terapia , Gatos , Doenças do Cão/patologia , Doenças do Cão/terapia , Cães , Mastócitos/patologia , Mastocitose/diagnóstico , Mastocitose/patologia , Mastocitose/terapia , Síndromes Paraneoplásicas/diagnóstico , Síndromes Paraneoplásicas/patologia , Síndromes Paraneoplásicas/terapia , Síndromes Paraneoplásicas/veterináriaAssuntos
Doenças do Cão/patologia , Mastocitoma Cutâneo/veterinária , Neoplasias Cutâneas/veterinária , Animais , Diagnóstico Diferencial , Cães , Feminino , Imuno-Histoquímica/veterinária , Masculino , Mastocitoma Cutâneo/patologia , Estadiamento de Neoplasias/veterinária , Neoplasias Cutâneas/patologiaRESUMO
Results of the treatment with a combination of carboplatin and piroxicam in seven dogs with advanced non-tonsillar oral squamous cell carcinoma (SCC) were retrospectively analysed. This multi-agent protocol was well tolerated by all dogs and resulted in a complete regression of the tumour without additional surgery in four of seven patients. Additional surgery was necessary to remove a metastatic lymph node in one dog and residual tumour in a second dog, which achieved a partial response following medical therapy. Median follow-up for all the dogs was 534 days, while the time-to-recurrence, time-to-progression and overall survival for this group of patients have not yet been reached. Our study, although limited in number of animals, suggests that this multiagent approach is a useful treatment option for oral non-tonsillar SCC in dogs and warrants wider application.
RESUMO
Six cats with an advanced stage squamous cell carcinoma (SCC) of the nasal planum were treated with a combination of superficial radiotherapy and intralesional carboplatin therapy. This multimodality protocol was well tolerated by the majority of cats and resulted in complete responses in all cats (100%). Median follow-up for all cats is 268 days, and the median time-to-recurrence, time-to-progression and overall survival have not yet been reached. Our study, although limited in number of animals and with a relatively short median follow-up compared to other studies for this disease, suggests that a combination of radiotherapy and intralesional carboplatin is a useful treatment option for an advanced stage SCC of the nasal planum in cats and warrants further application of the multimodality approach presented here.
RESUMO
A clustering of generalized malignant lymphoma is reported in a single household of Rottweiler dogs (both parents and three of the four sibling in one litter) and in a breeding pair of unrelated Scottish terriers. In addition, malignant lymphoma of the myocardium was found in three directly related otterhounds (the sire and two sibling offspring). Possible genetic and viral factors in the aetiology of canine malignant lymphoma are discussed.
Assuntos
Doenças do Cão/genética , Linfoma/veterinária , Animais , Análise por Conglomerados , Cães , Feminino , Linfoma/complicações , Linfoma/genética , Masculino , LinhagemRESUMO
A case of infection with the fur mite of domestic rabbits, Listrophorus gibbus, is reported. Possible methods of treatment of individual rabbits as well as of colonies of rabbits are reviewed. The presence of Listrophorus gibbus in conjunction with Cheyletiella parasitivorax is also discussed.