RESUMO
Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, the alarms issued by regulatory agencies and therapeutic alternatives.
Assuntos
Fluoroquinolonas , Tendinopatia , Humanos , Fluoroquinolonas/efeitos adversos , Antibacterianos/efeitos adversos , Tendinopatia/induzido quimicamenteRESUMO
TITLE: I Concurso de casos clínicos 'Abre los ojos en narcolepsia'.
Assuntos
Narcolepsia , Humanos , Narcolepsia/diagnóstico , OlhoRESUMO
Dalbavancin is a long-acting antimicrobial agent with an excellent in vitro activity against Gram-positive pathogens, including staphylococcal biofilms. The unusually long terminal half-life ranging from 149 to 250 hours in human subjects, allows a weekly dose. Currently is indicated in acute bacterial skin and skin structure infections (ABSSSIs), but in real-life clinical practice it has already been used successfully and safely in other infections, especially as consolidation therapy.
Assuntos
Infecções por Bactérias Gram-Positivas , Dermatopatias Infecciosas , Antibacterianos/uso terapêutico , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Humanos , Dermatopatias Infecciosas/tratamento farmacológico , Staphylococcus , Teicoplanina/análogos & derivados , Teicoplanina/uso terapêuticoRESUMO
Oral antibiotics are among the most frequently used medications in the community. Its adverse effects are generally considered to be infrequent and mild, and include allergies, toxicities and drug interactions. Antibiotics are able to harm patients by various mechanisms, not always well known. Knowledge of the clinically relevant antibiotic-associated adverse effects can allow a judicious use based on the principle first do no harm, primun non nocere. In this review we explore the main adverse effects of oral antibiotics with specific focus on ß-lactams, macrolides, and fluoroquinolones.