Epidemiological Overview of Overweight and Obesity Related to Eating Habits, Physical Activity and the Concurrent Presence of Depression and Anxiety in Adolescents from High Schools in Mexico City: A Cross-Sectional Study.

Overweight and obesity in adolescents has become a serious public health problem worldwide and Mexico City is no exception. Therefore, the objective of this study was to investigate the epidemiological panorama of overweight and obesity related to eating habits, physical activity and the concurrent presence of depression and anxiety in adolescents from high schools in Mexico City. Anthropometric measurements were taken from 2710 adolescents from 33 participating high schools. Likewise, a previously validated eating habit and physical activity questionnaire was administered, which consisted of four different sections, where each of the sections focused on key aspects of the participants' lifestyle: (1) eating habits, (2) intake of non-recommended foods, (3) food and company environment, and (4) physical activity. Moreover, the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression was applied. In this study, a high prevalence of overweight and obesity (26.5% overweight and 20.0% obese) was found in adolescents from high schools in Mexico City. Only 13.14% of participants had adequate eating habits and 18.19% physical activity habits. An association was found between having inadequate eating habits and obesity in adolescent women (OR = 1.95; CI 1.009-3.76). Additionally, associations were observed between depression symptoms and obesity (OR = 5.68, CI 1.36-32.81; p = 0.01), while anxiety was associated with underweight and obesity adjusted by other dietary habits and psychological factors. Therefore, it is important to identify adolescents with overweight or obesity and establish prevention strategies for weight control in this age group, promoting healthy eating, physical activity and education in mental health.

Inmunoexpresión de biomarcadores Bax, Bcl-2, CD138, H3, Ki-67, MCM3 y p53 en liquen plano oral / Immunoexpression of biomarkeres BAX, BCL-2, CD-138, H3, Ki-67, MCM3 AND p53 in oral lichen planus

El objetivo del presente trabajo fue determinar la expresión de diversos biomarcadores moleculares en liquen plano oral para ayudar a comprender su conducta biológica. Materiales y métodos: Se realizó un estudio inmunohistoquímico en 40 casos de liquen plano oral contra BAX, BCL-2, CD-138, Histona 3, Ki-67, MCM3 y p53, en el Área de Patología Molecular Estomatológica de la Facultad de Odontología, UDELAR, Uruguay. Resultados: Se observó mayor expresión de BAX en contraposición con BCL-2, sugiriendo un comportamiento proapoptótico, respaldado a su vez por la ausencia de expresión de p53. La expresión de los marcadores de proliferación celular fue en todo el tejido lesional observado, sugiriendo así alteraciones de la proliferación. CD-138 se expresó de manera intensa y uniforme, determinando una baja alteración de las uniones intercelulares para estos casos. Conclusiones: La alteración en la expresión de las proteínas estudiadas sugiere un trastorno en los mecanismos proliferativos y apoptóticos, los cuales se asocian con una conducta patológica de la mucosa oral.

This study aims to establish an association of the expression of specific biomarkers in oral lichen planus to understandits biological behavior. Materials and methods: An immunohistochemistry study was conducted in 40 cases of oral lichen planus against BAX, BCL-2, CD138, Histone 3, Ki-67, MCM3 and p53 at the Molecular Pathology Area of the School of Dentistry, UDELAR, Uruguay. Results: A greater expression of BAX was detected compared to BCL-2, suggesting a pro-apoptotic behavior, supported by the absence of p53 expression. MCM3 expression was more sensitive than Ki-67, considering proliferation alterations. CD-138 had a more intense and uniform expression, determining fewer intercellular adhesion alterations. Conclusions: The expression of the proteins studied suggests an alteration in proliferative and apoptotic mechanisms, associated with a pathological behavior of the oral mucosa.

O objetivo deste trabalho foi determinar a expressão de vários biomarcadores moleculares no líquen plano oral para ajudar a compreender seu comportamento biológico. Materiais emétodos: Foi realizado um estudo imunohistoquímico em 40 casos de líquen plano oral contra BAX, BCL-2, CD-138, Histona 3, Ki-67, MCM3 e p53, na área de Patologia Molecular Estomatológica da Faculdade de Odontologia , UDELAR, Uruguai. Resultados: Observou-se aumento da expressão de BAX em contraste com BCL-2, sugerindo um comportamento proapoptótico, apoiado por sua vez pela ausência da expressão de p53. A expressão de marcadores de proliferação celular foi observada em todo o tecido da lesão, sugerindo alterações na proliferação. CD-138 foi expressado de maneira intensa e uniforme, determinando uma baixa alteração das junções intercelulares para esses casos. Conclusões: A alteração na expressão das proteínas estudadas sugere um distúrbio nos mecanismos proliferativos e apoptóticos, os quais estão associados a um comportamento patológico da mucosa oral.

[Intervention for the promotion on the consumption of milk and dairy products as a strategy to reduce overweight in adolescents of México]. / Intervención para el fomento del consumo de leche y productos lácteos como parte de una estrategia para la disminución del exceso de peso en adolescentes de la Ciudad de México.

INTRODUCTION: Introduction: the consumption of milk and dairy products can play an important role in the maintenance of healthy body weight, since, under normal conditions of individuals, a negative association has been observed between daily intake of calcium contained in milk and dairy products and adiposity markers. Objective: to determine if the consumption of milk and dairy products affects the body weight reduction of adolescents in high school in Mexico City. Methods: community trial with 2,368 adolescents in three phases: description of the initial nutritional status, multidisciplinary educational intervention in the intervention group and evaluation of the changes observed. A food frequency and reminder questionnaire of 24 hours was applied to the participants, anthropometric measures were taken and the Who Anthro Plus® program was used to obtain the nutritional diagnosis. Results: it was found, in the intervention group, that adolescents who never consume whole milk, skimmed milk, fresh cow's cheese and natural yogurt have a higher prevalence of obesity (15.8%, 12.5%, 19.0% and 19.0%, respectively), compared to the adolescents who consume them daily (0.0%, 0.0%, 2.3% and 5.6%, respectively), there being a highly significant difference for the consumption of cheese fresh cow's milk and natural yogurt (p ≤ 0.01). It was possible to increase the frequency of dairy consumption and changes in nutritional status were observed in the intervention group, where the prevalence of obesity decreased from 13.8% to 6.1%. Conclusions: adolescents with higher milk consumption and its dairy products had a lower prevalence of obesity.

INTRODUCCIÓN: Introducción: el consumo de leche y productos lácteos puede jugar un papel importante en el mantenimiento del peso corporal saludable, ya que, en condiciones normales de los individuos, se ha observado una asociación negativa entre la ingesta diaria del calcio contenido en la leche y los productos lácteos con el incremento adipositario. Objetivo: determinar si el consumo de leche y productos lácteos repercute en la disminución del peso corporal de los adolescentes de escuelas secundarias de la Ciudad de México. Métodos: ensayo comunitario con 2.368 adolescentes en tres fases: descripción del estado de nutrición inicial, intervención educativa multidisciplinaria en el grupo intervención y evaluación de los cambios observados. Se aplicó a los participantes un cuestionario de frecuencia de consumo de alimentos y recordatorio de 24 horas, se tomaron medidas antropométricas y se utilizó el programa Who Anthro Plus® para obtener el diagnóstico nutricional. Resultados: se encontró, en el grupo de intervención, que los adolescentes que nunca consumen leche entera, leche descremada, queso fresco de vaca y yogur natural presentan mayor prevalencia de obesidad (15,8%, 12,5%, 19,0% y 19,0%, respectivamente), en comparación con los adolescentes que los consumen diariamente (0,0%, 0,0%, 2,3% y 5,6%, respectivamente), con una diferencia altamente significativa para el consumo de queso fresco de vaca y yogurt natural (p ≤ 0,01). Se logró aumentar la frecuencia de consumo de lácteos y se observaron cambios en el estado de nutrición en el grupo de intervención, donde la prevalencia de obesidad disminuyó del 13,8% al 6,1%. Conclusiones: los adolescentes con mayor consumo de leche y productos lácteos presentaron menor prevalencia de obesidad.

Oral cysticercosis: a collaborative study of 16 cases.

Cysticercosis is a potentially fatal parasitic disease that rarely involves the oral region in humans. This study includes 21 lesions seen in 16 Latin American patients. There were 8 men and 8 women, with an age range from 6 to 67 years (mean 33.6 years). Most cases appeared as asymptomatic submucosal nodules that resembled mucous cysts or benign mesenchymal neoplasms. Most were found in the tongue (11 cases), followed by buccal mucosa and the lower lip (4 cases each) and upper lip (2 cases). These were well circumscribed, and ranged in size from 1 to 2.5 cm in diameter. Typical histologic features of viable cysticerci were observed in 15 cases, and the presence of colloid degeneration and granular mineralization were detected in only 1 case. In all cases, simple surgical excision was sufficient to ensure complete removal of the lesions without postoperative complications. It is important to carry out a detailed study in every case, in order to exclude the presence of the parasite in other sites.