Interferometric measurements beyond the coherence length of the laser source.

Interferometric measurements beyond the coherence length of the laser are investigated theoretically and experimentally in this paper. Thanks to a high-bandwidth detection, high-speed digitizers and a fast digital signal processing, we have demonstrated that the limit of the coherence length can be overcome. Theoretically, the maximal measurable displacement is infinite provided that the sampling rate is sufficiently short to prevent any phase unwrapping error. We could verify experimentally this concept using a miniature interferometer prototype, based on a frequency stabilized vertical cavity surface emitting laser. Displacement measurements at optical path differences up to 36 m could be realized with a relative stability better than 0.1 ppm, although the coherence length estimated from the linewidth and frequency noise measurements do not exceed 6.6 m.

Two-dimensional polymer grating and prism on Bloch surface waves platform.

A one-dimensional photonic crystal sustaining Bloch Surface Waves (BSWs) is used as a platform for two-dimensional integrated optics. The dielectric platform shows low loss, long propagation distance and high surface field enhancement. In order to study the potential of the platform for future photonic chips, polymer ultra-thin prisms and gratings (~100 nm) are engineered on the top of the platform. This polymer layer modifies the BSWs effective index enabling a direct manipulation of light. The BSW deflection effects caused by surface prisms are observed in the near-field and Snells law is verified; then the BSW diffractions through surface gratings are experimentally and theoretically characterized. The results show a robust platform that can be used for integrated optics that includes different optical components. One of the main advantages is that these 2D photonic devices can have arbitrary shapes, which is difficult to obtain in 3D.

Real-time amyloid aggregation monitoring with a photonic crystal-based approach.

We propose the application of a new label-free optical technique based on photonic nanostructures to real-time monitor the amyloid-beta 1-42 (Aß(1-42)) fibrillization, including the early stages of the aggregation process, which are related to the onset of the Alzheimer's Disease (AD). The aggregation of Aß peptides into amyloid fibrils has commonly been associated with neuronal death, which culminates in the clinical features of the incurable degenerative AD. Recent studies revealed that cell toxicity is determined by the formation of soluble oligomeric forms of Aß peptides in the early stages of aggregation. At this phase, classical amyloid detection techniques lack in sensitivity. Upon a chemical passivation of the sensing surface by means of polyethylene glycol, the proposed approach allows an accurate, real-time monitoring of the refractive index variation of the solution, wherein Aß(1-42) peptides are aggregating. This measurement is directly related to the aggregation state of the peptide throughout oligomerization and subsequent fibrillization. Our findings open new perspectives in the understanding of the dynamics of amyloid formation, and validate this approach as a new and powerful method to screen aggregation at early stages.

Cocaine detection by a mid-infrared waveguide integrated with a microfluidic chip.

A germanium (Ge) strip waveguide on a silicon (Si) substrate is integrated with a microfluidic chip to detect cocaine in tetrachloroethylene (PCE) solutions. In the evanescent field of the waveguide, cocaine absorbs the light near 5.8 µm, which is emitted from a quantum cascade laser. This device is ideal for (bio-)chemical sensing applications.

Temperature dependence of the frequency noise in a mid-IR DFB quantum cascade laser from cryogenic to room temperature.

We report on the measurement of the frequency noise power spectral density in a distributed feedback quantum cascade laser over a wide temperature range, from 128 K to 303 K. As a function of the device temperature, we show that the frequency noise behavior is characterized by two different regimes separated by a steep transition at ≈200 K. While the frequency noise is nearly unchanged above 200 K, it drastically increases at lower temperature with an exponential dependence. We also show that this increase is entirely induced by current noise intrinsic to the device. In contrast to earlier publications, a single laser is used here in a wide temperature range allowing the direct assessment of the temperature dependence of the frequency noise.