1.
Haematologica
; 107(6): 1470-1473, 2022 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35199505
Assuntos
Hepatite B Crônica , Leucemia Linfocítica Crônica de Células B , Adenina/análogos & derivados , Antivirais/efeitos adversos , Vírus da Hepatite B/fisiologia , Hepatite B Crônica/tratamento farmacológico , Humanos , Leucemia Linfocítica Crônica de Células B/complicações , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Piperidinas , Estudos Retrospectivos , Ativação Viral
2.
J Gen Virol
; 96(Pt 7): 1969-74, 2015 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25805411
RESUMO
In most forms of prion diseases, blood is infectious, but detection by immunochemistry techniques of the only available marker of infection (the misfolded prion protein, PrPTSE) in blood remains elusive. We developed a novel method for the detection of PrPTSE in blood of prion-infected rodents based on the finding that PrPTSE is associated with plasma exosomes. However, further purification of the exosomes on a sucrose gradient was necessary to remove plasma immunoglobulins, which interfere with PrPTSE, masking its detection by immunochemistry. Finally, we report that about 20% of plasma infectivity is associated with exosomes.