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Dalton Trans ; 46(42): 14556-14560, 2017 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-28702664

RESUMO

Following our previous work on the production of radiometals, such as 64Cu and 68Ga, through the irradiation of liquid targets using a medical cyclotron, we describe in this paper a technique to produce 61Cu through the irradiation of natural zinc using a liquid target. The proposed method is very cost-effective, as it avoids the use of expensive enriched material, and is fast, as a purified solution of 61CuCl2 is obtained in less than 30 min after the end of beam. Considering its moderate half-life of 3.33 h and favourable decay properties as a positron emitter, 61Cu is a very attractive nuclide for the labelling of PET tracers for pre-clinical and clinical use with PET as well as to support the intense R&D programmes being carried out worldwide by taking advantage of the rich and versatile chemistry of copper.


Assuntos
Radioisótopos de Cobre/química , Análise Custo-Benefício , Ciclotrons , Radioquímica/economia , Radioquímica/instrumentação , Pesquisa , Zinco/química , Fótons , Compostos Radiofarmacêuticos/química , Fatores de Tempo
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