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Angew Chem Int Ed Engl
; 52(49): 13067-70, 2013 Dec 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24281890
RESUMO
Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments inâ vivo and inâ vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.