RESUMO
Lichen planus (LP) is a common oral disorder which may represent the manifestation of a mucosal reaction to a variety of aetiological factors. Of the many immunological changes described in LP several may be epiphenomena although a cell-mediated immune response to unidentified antigens or antigenic changes clearly is involved. Associations with drugs or systemic disorders are well-defined in some patients but may, in others, be aleatoric. Finally, the prognosis of oral LP not only differs from that of cutaneous LP but there is little doubt that in a few instances LP is a premalignant condition.
Assuntos
Líquen Plano/etiologia , Doenças da Boca/etiologia , Corticosteroides/uso terapêutico , Adulto , Idoso , Doenças Autoimunes , Infecções Bacterianas , Criança , Complicações do Diabetes , Feminino , Humanos , Imunoglobulinas/análise , Lactente , Líquen Plano/tratamento farmacológico , Líquen Plano/imunologia , Líquen Plano/microbiologia , Líquen Plano/patologia , Líquen Plano/fisiopatologia , Masculino , Pessoa de Meia-Idade , Doenças da Boca/tratamento farmacológico , Doenças da Boca/imunologia , Doenças da Boca/microbiologia , Doenças da Boca/patologia , Doenças da Boca/fisiopatologiaRESUMO
One hundred and thirteen patients with histologically confirmed oral lichen planus, from three stomatology clinics, were examined for evidence of liver disease. No patient had clinical evidence of liver disease. Nine patients (7.9%) had a raised serum concentration of a single enzyme; 6 patients had raised gamma-glutamyl transpeptidase, 2 had raised alkaline phosphatase, and 1 had raised aspartate transaminase levels. No patient had serum auto-antibodies suggestive of primary biliary cirrhosis or chronic active hepatitis. Most patients presenting with oral lichen planus are unlikely to have liver disease.
