Effect of praziquantel therapy on testes of mice infected with Schistosoma mansoni.

Histopathological changes in the testes of mice infected with S. mansoni before and after praziquantel therapy in early infection and late infection were studied. In early infection, 150 mg/kg of praziquantel regimen gave a very good effect comparable with 300 mg/kg dose. In both regimens the testes returned almost to normal activity after treatment. In late infection 150 mg/kg of praziquantel gave moderate improvement in spermatogenic activity compared to almost complete cure and return to full activity with 300 mg/kg praziquantel regimens. Also, any possible side effects of the drug on the testicles were looked for. The present study proved the safety use of the drug as regard to its testicular effects.