[The pathogenic aspects of fat acids metabolism with short chain and production of cytokines in target affected areas of skin under psoriasis].

The article deals with the results of analysis of specters of short-chained fat acids and cytokines in affected skin of patients with psoriasis. The study revealed the significant decrease of short-chained fat acids level, the shift of cytokine profile in the direction of anti-inflammatory factors (interleukins 1L-1beta, IL-8, tumor necrosis factor TNF-alpha, interferon IFN-alpha) and mytogenetic factors (EGF) on the background of stable values of anti-inflammatory cytokine IL-4. The direct pathogenically significant correlation relationships are established between the IL-4 level and the amount of most analyzed short-chained fat acids. The negative correlation relationships were established between content of C2 and IL-1beta.

[Changes in the fatty-acid spectrum of epidermal structures in various age group patients with psoriasis].

The paper depicts changes in the epidermal fatty-acid spectrum in patients with psoriasis progressing to the stage of dermatosis in various age groups (18-40 and 41-60 years). The parameters studied in healthy individuals showed age-related differences in the pool of saturated and unsaturated fatty acids (SCFA). Heterodirectional changes in the epidermal levels of saturated, polyenic, and monoenic fatty acids were recorded in the lesion foci and visually healthy skin of patients with psoriasis depending on age.

[Variability of quantitative changes in short-chain fatty acids in serum and epidermis in psoriasis].

Gas liquid chromatography was used to study the spectrum of short-chain fatty acids (SCFA) in the serum and epidermal corneal layers of abnormal and apparently healthy skin areas in patients with psoriatic disease on an exacerbation and at a progressive stage. Significantly lower SCFA levels were detected in both psoriatic and intact areas, with derangements being mostly manifested in the papulae. There were heterodirectional serum volatile fatty acid spectrum changes that were characterized by a rise in the concentrations of isobutyrate, valeriate, and capronate and by a decrease in the proportion of acetate and propionate.

[Changes in lipid peroxidation in psoriasis]. / Izmeneniia perekisnogo okisleniia lipidov pri psoriaze.

Changes of the lipid peroxidation processes (LP) in the skin (corneal layer of the epidermis) and in blood, as observed in 61 patients with local psoriasis at the progressing stage and in 55 patients with local psoriasis at remission, were investigated. The quantity of diene conjugates, ketodienes, and of conjugate trienes in the heptanoic and isopropanol phases was decreasing both in the affected and intact skins versus the controls. The test based on thiobarbituric acid (TBA) was used to establish that the content of the TBA-positive products was also decreasing. The examined values did not reach the control figures at remission. The content of the studied indices in blood was reliably higher than the control figures in all lipid extract phases at exacerbation of the dermal affection; it did not decrease after the main dermal lesion was eliminated. The correlation analysis revealed the presence of correlations between the studied parameters in blood and skin, which were changing with respect to a stage of the dermal affection.

[Lipid peroxidation processes in epidermis of patients with psoriasis]. / Protsessy lipoperoksidatsii v épidermise bol'nykh psoriazom.

The evaluation of local peroxide status was studied in 42 patients with psoriasis depending on the disease stage in different age periods (from 18 to 67 years) with disease duration from 2 months to 20 years. It was established that the development of psoriatic process is accompanied with the marked changes in local peroxide status in the epidermis. It is manifested by the decrease in intensity of lipid free-and-radical oxidation. Decrease in the products of lipoperoxidation occurs in epidermis--both in the affected and intact areas in all investigated patients independently of the stage of psoriatic process. It is more expressed during the aggravation period. The minimal levels of the intermediators being studied are recorded in the psoriatic plaques.