Factor analysis of the relationship between PANSS score and family burden of patients with schizophrenia.

OBJECTIVE: This study aims to investigate the burden of family caregivers of patients with schizophrenia, and its influencing factors METHODS: A total of 105 patients with schizophrenia and their caregivers were investigated using the positive and negative symptom scale (PANSS) and family burden scale of disease (FBS) RESULTS: There was a strong correlation between the patient's recovery and family burden, especially between positive and negative symptoms and family financial burden, family daily activities, family recreational activities, and family relationship CONCLUSION: There is a strong correlation between the patient's recovery and family burden, and this is especially correlated to family economic burden, family daily activities, family recreational activities, and family relationship. Medical staff should pay attention to the psychological characteristics of patients and fully understand and avoid the adverse effects of family burden on the rehabilitation of patients.

Effects of dasatinib on the proliferation and invasion and metastasis of breast cancer / 中国现代普通外科进展

Objective:Our study attempts to investigate the effects and the mechanism of dasatinib on the proliferation,invasion and metastasis of triple-negative breast cancer (TNBC) cells.Method:TNBC Hs578T cells were tested for the sensitivity to dasatinib in vitro using PrestoBlueTM reagent and mammosphere assay.Transwell assay and wound-healing assay were used to determine invasion and metastasis ability of Hs578T cells.The p-STAT3 and STAT3 expressions of dasatinib]treated Hs578T cells were measured by Western blot.Results:Dasatinib exhibited growth inhibition of Hs578T cells.Mammosphere assay showed that dasatinb treatment led to less mammosphere formation of TNBC cells.More importantly,migration and invasion ability of Hs578T cells was also decreased by dasatinib treatment.Western blot analysis revealed that the p-STAT3 level was decreased significantly in Hs578T cells after dasatinib treatment,compared with control group.Conclusions:Dasatinib prevents the proliferation,invasion and metastasis ability of TNBC cells via inhibiting STAT3 pathway.