Five-year results of inguinal hernia treatment with the Prolene Hernia System in a regional training hospital.

PURPOSE: Long-term results of inguinal hernia repair with the Prolene Hernia System (PHS) in our regional training hospital were retrospectively analysed. Research was conducted in an identical cohort of patients previously investigated for short-term results. METHODS: One-hundred and fifty-eight patients (217 inguinal hernias) treated with the PHS were traced and included. Patients were invited to visit the outpatient clinic for a brief history, physical examination and ultrasound. A quality of life questionnaire was completed by all patients. The primary endpoint was recurrence rate. Testis atrophy, chronic pain and hypaesthesia were secondary endpoints. RESULTS: The mean age of the population (n = 187) was 62.2 years (range 28-92), with a male:female ratio of 15:1 (175:12). The median follow-up was 5.5 years (range 3.9-6.8). One-hundred and forty-five patients visited the outpatient clinic, while 13 patients were included by telephone interview. Twenty-one patients died during follow-up and eight others were lost to follow-up. The resulting follow-up rate was 85% (158/187). In our initial study, we found four recurrences (1.8%) and seven patients with persisting pain (3.2%) after 32 months. During current follow-up, five patients were diagnosed with recurrent herniation (2.3%, 5/217) and only four patients (1.8%) suffered from persisting pain. Three patients (1.4%) were diagnosed with testicular atrophy, while ten patients (4.4%) experienced hypaesthesia. CONCLUSION: In a regional training hospital, the recurrence rate and long-term complications of patients treated for inguinal hernia with the PHS are acceptable after a follow-up of 5.5 years. The number of patients experiencing persistent pain seems to decrease over time.

Inguinal hernia treatment with the Prolene Hernia System in a Dutch regional training hospital.

INTRODUCTION: In this retrospective study results from inguinal hernia repair with the Prolene Hernia System (PHS) in a regional training hospital were analysed. PATIENTS AND METHODS: One-hundred and seventy-eight primary inguinal hernias and thirty-nine recurrent hernias (initial non-mesh repair) were treated with the PHS. The primary endpoint was the recurrence rate. Secondary endpoints were short-term and long-term complications. Pain was evaluated by use of a visual analog scale (VAS, 0-100), and a short-form 36-item questionnaire was used to assess postoperation quality of life. All patients visited the outpatient clinic for a physical examination (100% follow-up). RESULTS: After a median follow-up of 32 months four patients were diagnosed with recurrent herniation (1.8%), three after primary hernia repair (1.6%) and one after recurrent hernia repair (2.6%). Three superficial wound infections (1.3%), three haematomas needing surgical evacuation (1.3%), and two lesions of the spermatic cord (0.9%) were diagnosed. Seven patients (3.2%) suffered from persistent pain (VAS > 40). Average VAS score was 13 (0-80) >24 months after surgery. CONCLUSION: In a regional training hospital, primary and recurrent inguinal hernias were treated with low recurrence and few complications by use of the PHS.

Effect of comorbidity on the treatment and prognosis of elderly patients with non-small cell lung cancer.

BACKGROUND: With the rising mean age, more patients will be diagnosed with one or more other serious diseases at the time of lung cancer diagnosis. Little is known about the best way to treat elderly patients with comorbidity or the outcome of treatment. This study was undertaken to evaluate the independent effects of age and comorbidity on treatment and prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: All patients with NSCLC diagnosed between 1995 and 1999 in the southern part of the Netherlands (n = 4072) were included. RESULTS: The proportion of patients with localised NSCLC who underwent surgery was 92% in patients younger than 60 years and 9% in those aged 80 years or older. In patients aged 60-79 years this proportion also decreased with comorbidity. In patients with non-localised NSCLC the proportion receiving chemotherapy was considerably higher for those aged less than 60 years (24%) than in those aged 80 or older (2%). The number of comorbid conditions had no significant influence on the treatment chosen for patients with non-localised disease. Multivariable survival analyses showed that age, tumour size, and treatment were independent prognostic factors for patients with localised disease, and stage of disease and treatment for those with non-localised disease. Comorbidity had no independent prognostic effect. CONCLUSIONS: It is questionable whether the less aggressive treatment of elderly patients with NSCLC is justified.

Anatomical considerations for surgery of the anterolateral abdominal wall.

Closure of large incisional hernias with the Components Separation Method (CSM) could be explained by medial-caudal rotation of the internal and transverse oblique muscles around their centres of origin. In eight human cadavers, the CSM was performed, and translation of the rectus abdominis muscle was measured. Mean unilateral translation of the rectus abdominis in the lateral-medial direction measured 2.2, 3.7, and 3.5 cm. This was 2.7, 4.5, and 4.0 cm after release of the posterior rectus sheath. Mean translation in a caudal direction was 0.5 cm, but seven cadavers showed a mean translation of 1 cm of the uppermost measuring point in a cranial direction. The hypothesis that rotation of separate tissue layers of the abdominal wall largely accounts for the translation effect of the CSM must be rejected. Release of the external oblique muscle produces more benefit to abdominal wall closure than release of the posterior rectus sheath.