External Hardware and Sensors, for Improved MRI.

Complex engineered systems are often equipped with suites of sensors and ancillary devices that monitor their performance and maintenance needs. MRI scanners are no different in this regard. Some of the ancillary devices available to support MRI equipment, the ones of particular interest here, have the distinction of actually participating in the image acquisition process itself. Most commonly, such devices are used to monitor physiological motion or variations in the scanner's imaging fields, allowing the imaging and/or reconstruction process to adapt as imaging conditions change. "Classic" examples include electrocardiography (ECG) leads and respiratory bellows to monitor cardiac and respiratory motion, which have been standard equipment in scan rooms since the early days of MRI. Since then, many additional sensors and devices have been proposed to support MRI acquisitions. The main physical properties that they measure may be primarily "mechanical" (eg acceleration, speed, and torque), "acoustic" (sound and ultrasound), "optical" (light and infrared), or "electromagnetic" in nature. A review of these ancillary devices, as currently available in clinical and research settings, is presented here. In our opinion, these devices are not in competition with each other: as long as they provide useful and unique information, do not interfere with each other and are not prohibitively cumbersome to use, they might find their proper place in future suites of sensors. In time, MRI acquisitions will likely include a plurality of complementary signals. A little like the microbiome that provides genetic diversity to organisms, these devices can provide signal diversity to MRI acquisitions and enrich measurements. Machine-learning (ML) algorithms are well suited at combining diverse input signals toward coherent outputs, and they could make use of all such information toward improved MRI capabilities. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 1.

Control of a wireless sensor using the pulse sequence for prospective motion correction in brain MRI.

PURPOSE: To synchronize and pass information between a wireless motion-tracking device and a pulse sequence and show how this can be used to implement customizable navigator interleaving schemes that are part of the pulse sequence design. METHODS: The device tracks motion by sampling the voltages induced in 3 orthogonal pickup coils by the changing gradient fields. These coils were modified to also detect RF-transmit events using a 3D RF-detection circuit. The device could then detect and decode a set RF signatures while ignoring excitations in the parent pulse sequence. A set of unique RF signatures were then paired with a collection of navigators and used to trigger readouts on the wireless device synchronous to the pulse sequence execution. Navigator interleaving schemes were then demonstrated in 3D RF-spoiled gradient echo, T1 -FLAIR (fluid-attenuated inversion recovery) PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction), and T2 -FLAIR PROPELLER pulse sequences. RESULTS: Excitations in the parent pulse sequences were successfully rejected and the RF signatures successfully decoded. For the 3D gradient echo sequence, distortions were removed by interleaving flipped polarity navigators and taking the difference between consecutive readouts. The impact on scan duration was reduced by 54% by breaking up the navigators into smaller parts. Successful motion correction was performed using the PROPELLER pulse sequences in 3 Tesla and 1.5 Tesla MRI scanners without modifications to the device hardware or software. CONCLUSION: The proposed RF signature-based triggering scheme enables complex interactions between the pulse sequence and a wireless device. Thus, enabling prospective motion correction that is repeatable, versatile, and minimally invasive with respect to hardware setup.

NeuroMix-A single-scan brain exam.

PURPOSE: Implement a fast, motion-robust pulse sequence that acquires T1 -weighted, T2 -weighted, T2* -weighted, T2 fluid-attenuated inversion recovery, and DWI data in one run with only one prescription and one prescan. METHODS: A software framework was developed that configures and runs several sequences in one main sequence. Based on that framework, the NeuroMix sequence was implemented, containing motion robust single-shot sequences using EPI and fast spin echo (FSE) readouts (without EPI distortions). Optional multi-shot sequences that provide better contrast, higher resolution, or isotropic resolution could also be run within the NeuroMix sequence. An optimized acquisition order was implemented that minimizes times where no data is acquired. RESULTS: NeuroMix is customizable and takes between 1:20 and 4 min for a full brain scan. A comparison with the predecessor EPIMix revealed significant improvements for T2 -weighted and T2 fluid-attenuated inversion recovery, while taking only 8 s longer for a similar configuration. The optional contrasts were less motion robust but offered a significant increase in quality, detail, and contrast. Initial clinical scans on 1 pediatric and 1 adult patient showed encouraging image quality. CONCLUSION: The single-shot FSE readouts for T2 -weighted and T2 fluid-attenuated inversion recovery and the optional multishot FSE and 3D-EPI contrasts significantly increased diagnostic value compared with EPIMix, allowing NeuroMix to be considered as a standalone brain MRI application.

Motion-insensitive susceptibility weighted imaging.

PURPOSE: To enable SWI that is robust to severe head movement. METHODS: Prospective motion correction using a markerless optical tracker was applied to all pulse sequences. Three-dimensional gradient-echo and 3D EPI were used as reference sequences, but were expected to be sensitive to motion-induced B0 changes, as the long TE required for SWI allows phase discrepancies to accumulate between shots. Therefore, 2D interleaved snapshot EPI was investigated for motion-robust SWI and compared with conventional 2D EPI. Repeated signal averages were retrospectively corrected for motion. The sequences were evaluated at 3 T through controlled motion experiments involving two cooperative volunteers and SWI of a tumor patient. RESULTS: The performed continuous head motion was in the range of 5-8° rotations. The image quality of the 3D sequences and conventional 2D EPI was poor unless the rotational motion axis was parallel to B0 . Interleaved snapshot EPI had minimal intraslice phase discrepancies due to its small temporal footprint. Phase inconsistency between signal averages was well tolerated due to the high-pass filter effect of the SWI processing. Interleaved snapshot EPI with prospective and retrospective motion correction demonstrated similar image quality, regardless of whether motion was present. Lesion depiction was equal to 3D EPI with matching resolution. CONCLUSION: Susceptibility-based imaging can be severely corrupted by head movement despite accurate prospective motion correction. Interleaved snapshot EPI is a superior alternative for patients who are prone to move and offers SWI which is insensitive to motion when combined with prospective and retrospective motion correction.

T1 -FLAIR imaging during continuous head motion: Combining PROPELLER with an intelligent marker.

PURPOSE: The purpose of this work is to describe a T1 -weighted fluid-attenuated inversion recovery (FLAIR) sequence that is able to produce sharp magnetic resonance images even if the subject is moving their head throughout the acquisition. METHODS: The robustness to motion artifacts and retrospective motion correction capabilities of the PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) trajectory were combined with prospective motion correction. The prospective correction was done using an intelligent marker attached to the subject. This marker wirelessly synchronizes to the pulse sequence to measure the directionality and magnitude of the magnetic fields present in the MRI machine during a short navigator, thus enabling it to determine its position and orientation in the scanner coordinate frame. Three approaches to incorporating the marker-navigator into the PROPELLER sequence were evaluated. The specific absorption rate, and subsequent scan time, of the T1 -weighted FLAIR PROPELLER sequence, was reduced using a variable refocusing flip-angle scheme. Evaluations of motion correction performance were done with 4 volunteers and 3 types of head motion. RESULTS: During minimal out-of-plane movement, retrospective PROPELLER correction performed similarly to the prospective correction. However, the prospective clearly outperformed the retrospective correction when there was out-of-plane motion. Finally, the combination of retrospective and prospective correction produced the sharpest images even during large continuous motion. CONCLUSION: Prospective motion correction of a PROPELLER sequence makes it possible to handle continuous, large, and high-speed head motions with only minor reductions in image quality.

Prospective motion correction for diffusion weighted EPI of the brain using an optical markerless tracker.

PURPOSE: To enable motion-robust diffusion weighted imaging of the brain using well-established imaging techniques. METHODS: An optical markerless tracking system was used to estimate and correct for rigid body motion of the head in real time during scanning. The imaging coordinate system was updated before each excitation pulse in a single-shot EPI sequence accelerated by GRAPPA with motion-robust calibration. Full Fourier imaging was used to reduce effects of motion during diffusion encoding. Subjects were imaged while performing prescribed motion patterns, each repeated with prospective motion correction on and off. RESULTS: Prospective motion correction with dynamic ghost correction enabled high quality DWI in the presence of fast and continuous motion within a 10° range. Images acquired without motion were not degraded by the prospective correction. Calculated diffusion tensors tolerated the motion well, but ADC values were slightly increased. CONCLUSIONS: Prospective correction by markerless optical tracking minimizes patient interaction and appears to be well suited for EPI-based DWI of patient groups unable to remain still including those who are not compliant with markers.

Chemical shift encoding using asymmetric readout waveforms.

PURPOSE: To describe a new method for encoding chemical shift using asymmetric readout waveforms that enables more SNR-efficient fat/water imaging. METHODS: Chemical shift was encoded using asymmetric readout waveforms, rather than conventional shifted trapezoid readouts. Two asymmetric waveforms are described: a triangle and a spline. The concept was applied to a fat/water separated RARE sequence to increase sampling efficiency. The benefits were investigated through comparisons to shifted trapezoid readouts. Using asymmetric readout waveforms, the scan time was either shortened or maintained to increase SNR. A matched in-phase waveform is also described that aims to improve the SNR transfer function of the fat and water estimates. The sequence was demonstrated for cervical spine, musculoskeletal (MSK), and optic nerve applications at 3T and compared with conventional shifted readouts. RESULTS: By removing sequence dead times, scan times were shortened by 30% with maintained SNR. The shorter echo spacing also reduced T2 blurring. Maintaining the scan times and using asymmetric readout waveforms achieved an SNR improvement in agreement with the prolonged sampling duration. CONCLUSIONS: Asymmetric readout waveforms offer an additional degree of freedom in pulse sequence designs where chemical shift encoding is desired. This can be used to significantly shorten scan times or to increase SNR with maintained scan time.

RARE two-point Dixon with dual bandwidths.

PURPOSE: To investigate the impact of dual readout bandwidths (dBW) in a dual echo fat/water acquisition and describe a dBW-rapid acquisition relaxation enhanced, or turbo spin echo sequence where the concept is used to improve SNR by removing dead times between refocusing pulses and avoiding redundant Chemical-shift encoded. METHODS: Cramér-Rao bounds and Monte Carlo simulations were used to investigate a two-point fat/water model where the difference in bandwidths is incorporated. In vivo images were acquired at 1.5 and 3 T with the dBW-rapid acquisition relaxation enhanced, or turbo spin echo sequence. Typical bandwidth ratios were 1:2. SNR was compared with a single bandwidth sequence under identical scan parameters at 3T. RESULTS: Monte Carlo simulations and Cramér-Rao analysis demonstrate that number of signal averages can be improved with dual bandwidths compared to conventional single bandwidth acquisitions. The dBW-rapid acquisition relaxation enhanced, or turbo spin echo sequence can acquire images with high readout resolutions with well-conditioned sampling. An SNR improvement of 52% was measured, in line with the theoretical gain of 54%. CONCLUSIONS: The proposed dBW-rapid acquisition relaxation enhanced, or turbo spin echo sequence is a highly SNR-efficient two-point rapid acquisition relaxation enhanced, or turbo spin echo sequence without dead times, and can acquire images at higher resolutions than current vendor-supplied alternatives.

Toward "plug and play" prospective motion correction for MRI by combining observations of the time varying gradient and static vector fields.

PURPOSE: The efficacy of a Wireless Radio frequency triggered Acquisition Device (WRAD) is evaluated for high frequency (50 Hz) prospective motion correction in a 3-dimensional spoiled gradient echo pulse sequence. METHODS: The device measures the rate of change in the gradient vector fields (slew) using a 3-dimensional assembly of Printed Circuit Board (PCB) inductors and the direction of the static magnetic field using a 3-axis Hall effect magnetometer. The slew vector encoding is highly efficient, because the Maxwell-term position encoding is observable, allowing overconstrained pose measurement using 3 sinusoidal gradient pulses lasting 880 µs. Since small offsets in the magnetometer can introduce bias into the pose estimates, sensor/system biases are tracked using a lightweight Kalman filter. The only calibration required is determining a geometric scaling factor for the pickup coils, which is specific to the device and will therefore be valid in any scanner. RESULTS: The device was used to perform prospective motion correction in 3 subjects, resulting in an increase in Average Edge Strength (AES) for involuntary and deliberate motion. CONCLUSIONS: The WRAD is simple to set up and use, with well-defined measurement variance. This could enable "plug and play" prospective motion correction if pulse sequence independence is achieved.

A Wireless Radio Frequency Triggered Acquisition Device (WRAD) for Self-Synchronised Measurements of the Rate of Change of the MRI Gradient Vector Field for Motion Tracking.

In this paper, we present a device that is capable of wireless synchronization to the MRI pulse sequence time frame with sub-microsecond precision. This is achieved by detecting radio frequency pulses in the parent pulse sequence using a small resonant circuit. The device incorporates a 3-axis pickup coil, constructed using conventional printed circuit board (PCB) manufacturing techniques, to measure the rate of change of the gradient waveforms with respect to time. Using Maxwell's equations, assuming negligible rates of change of curl and divergence, a model of the expected gradient derivative (slew) vector field is presented. A 3-axis Hall effect magnetometer allows for the measurement of the direction of the static magnetic field in the device co-ordinate frame. By combining the magnetometer measurement with the pickup coil voltages and slew vector field model, the orientation and position can be determined to within a precision of 0.1 degrees and 0.1 mm, respectively, using a pulse series lasting 880 µs . The gradient pulses are designed to be sinusoidal, enabling the detection of a phase shift between the time frame of the pickup coil digitization circuit and the gradient amplifiers. The signal processing is performed by a low power micro-controller on the device and the results are transmitted out of the scanner bore using a low latency 2.4 GHz radio link. The device identified an unexpected 40 kHz oscillation relating to the pulse width modulation frequency of the gradient amplifiers that is predominantly in the direction of the static magnetic field. The proposed wireless radio frequency triggered acquisition device enables users to probe the scanner gradient slew vector field with minimal hardware set-up and shows promise for the future developments in the prospective motion correction.

A Method for Measuring Orientation Within a Magnetic Resonance Imaging Scanner Using Gravity and the Static Magnetic Field (VectOrient).

In MRI brain imaging, subject motion limits obtainable image clarity. Due to the hardware layout of an MRI scanner, gradient excitations can be used to rapidly detect position. Orientation, however, is more difficult to detect and is commonly calculated by comparing the position measurements of multiple spatially constrained points to a reference dataset. The result is increased size of the apparatus the subject must wear, which can influence the imaging workflow. In optical based methods marker attachment sites are limited due to the line of sight requirement between the camera and marker, and an external reference frame is introduced. To address these challenges a method called VectOrient is proposed for orientation measurement that is based on vector observations of gravity and the MRI scanner's static magnetic field. A prototype device comprising of an accelerometer, magnetometer and angular rate sensor shows good MRI compatibility. Phantom scans of a pineapple with zero scanner specific calibration achieve comparable results to a rigid body registration algorithm with deviations less than 0.8 degrees over 28 degree changes in orientation. Dynamic performance shows potential for prospective motion correction as rapid changes in orientation (peak 20 degrees per second) can be corrected. The pulse sequence implemented achieves orientation updates with a latency estimated to be less than 12.7 ms, of which only a small fraction (<1 ms) is used for computing orientation from the raw sensor signals. The device is capable of quantifying subject respiration and heart rates. The proposed approach for orientation estimation could help address some limitations of existing methods such as orientation measurement range, temporal resolution, ease of use and marker placement.