Reproductive toxicants have a threshold of adversity.

This paper surveys the scientific basis for the current threshold approach for reproductive hazard and risk assessment. In some regulatory areas it was recently suggested to consider reproductive toxicants under the stringent linear extrapolation risk assessment paradigm that was developed for genotoxic carcinogens. First, the current risk assessment paradigm for genotoxic carcinogens is addressed, followed by an overview of reproductive toxicology and its threshold dose approach for hazard and risk assessment, the testing procedures for assessing the reproductive toxicity of chemicals, and the derivation of conclusions on their risk assessment and Classification, Labelling and Packaging (CLP). Relevant details of testing methodologies are discussed, such as exposure time windows, parameters determined, and the coverage of the entire reproductive cycle. In addition, the dose-response relationship is considered, illustrated with several examples. It is concluded that the current risk assessment methodology for genotoxic carcinogens is a debatable worst-case scenario and that for risk assessment of reproductive toxicants the threshold dose approach remains valid.

Risk assessment of peak exposure to genotoxic carcinogens: a pragmatic approach.

Short-term exposures to relatively high concentrations or doses are a regular cause of concern. Since carcinogenicity is often of great personal and social relevance the question arises whether short-term exposure (1-10 days) to a carcinogenic substance may contribute to tumour development and, if so, whether this contribution to the cancer risk can be quantified. The present object was to explore the possibility of a pragmatic estimation of the cancer risk of peak exposure to a genotoxic carcinogen relative to the cancer risk of the same cumulative dose of this carcinogen distributed over lifetime. A report published by the Health Council of The Netherlands served as point of departure. Published data strongly suggests that short-term or single exposure can indeed give rise to tumour formation in animal experiments. The application of a dose-rate correction factor (DRCF), defined as a factor by which the tumour incidence caused by a specific dose of a chemical carcinogen at low-dose rates is multiplied to derive the tumour incidence at high-dose rates, appears to be a feasible approach. Theoretical models calculated maximum values for the DRCF of up to seven for a young child acutely exposed to an initiator or first-stage carcinogen. A maximum value of 8.3 was calculated from animal experiments. A decision tree is presented which allows the pragmatic assessment of the carcinogenic risk following short-term exposure to genotoxic carcinogens. It is recommended to validate this decision tree with model-substances.