Assuntos
Anodontia/genética , Glândulas Écrinas/anormalidades , Neoplasias Palpebrais/genética , Hipotricose/genética , Ceratodermia Palmar e Plantar/genética , Mutação , Proteínas Wnt/genética , Adulto , Anodontia/diagnóstico , Anodontia/fisiopatologia , Criança , Análise Mutacional de DNA , Glândulas Écrinas/fisiopatologia , Neoplasias Palpebrais/diagnóstico , Neoplasias Palpebrais/fisiopatologia , Feminino , Predisposição Genética para Doença , Hereditariedade , Humanos , Hipotricose/diagnóstico , Hipotricose/fisiopatologia , Ceratodermia Palmar e Plantar/diagnóstico , Ceratodermia Palmar e Plantar/fisiopatologia , Masculino , Pessoa de Meia-Idade , Linhagem , FenótipoRESUMO
OBJECTIVE: To quantitatively compare the relationship between the congenital cleft palate and development of the palatal shelf. METHODS: Fifty two pairs palatal shelves were macroscopic measured, and 60 series coronal sections were microscopically measured, which were precisely orientated in the coronal plane and serially sectioned at 7 micro m thickness. With the aid of computer imaging analysis system the widths and areas of the palatal shelves in vertical and coronal direction, the maximal areas of the palatal bone and palatal process and alveolar process were measured and compared quantitatively between the cleft group and non-cleft group. RESULTS: The widths and areas of palatal shelves in cleft foetuses showed significant reduction macroscopically and microscopically as well as the maximal areas of the palatal bone, in addition, both of two processes of the maxilla showed significant developmental deficiency. CONCLUSIONS: The palatal shelves show significant developmental hypoplasia in three dimension directions, which have significant correlation between palatal cleft and trisomic condition.
Assuntos
Fissura Palatina/embriologia , Palato/anatomia & histologia , Animais , Fissura Palatina/genética , Feminino , Processamento de Imagem Assistida por Computador , Camundongos , Palato/embriologia , TrissomiaRESUMO
BACKGROUND: The development of an invasive squamous cell carcinoma within a lateral cervical cyst as a result of malignant transformation of the epithelium is considered a rare circumstance. The existence of this entity is a source of controversy in light of the differential diagnosis, which includes a cervical metastasis from an unknown primary carcinoma (CUP-syndrome). Apart from site, histologic findings, and follow-up, the principal diagnostic criterion for lateral cervical cyst carcinoma is the histomorphologic demonstration of transition of the benign epithelium into invasive squamous cell carcinoma. Although numerous case reports of this entity exist, carcinoma in situ in a lateral cervical cyst has been reported in only five cases thus far. METHOD: In this context, we present the case of a 44-year-old patient with a 7-month history of cervical swelling. RESULTS: After diagnostic extirpation of the tumor, histologic findings were consistent with a lateral branchial cyst with high-grade dysplasia and carcinoma in situ of the squamous epithelial lining. CONCLUSION: This case of a premalignant lesion within a lateral branchial cyst (ie, carcinoma in situ) supplies the "missing link" and adds credibility to the concept of primary branchiogenic carcinoma.
