Specific Game-Based Performance in Elite Male Adolescent Team Handball Players.

PURPOSE: In elite team handball, talent identification and selection of the best young players is a fundamental process in several national federations and clubs; however, literature addressing the specific game-based performance in team handball is almost nonexistent. Consequently, the aim of the study was to assess and compare the team-handball-specific game-based performance of elite male team handball players of different ages. METHODS: Twelve under-23, 10 under-19, 10 under-17, and 10 under-15 elite male players performed the team-handball game-based performance test. During testing, oxygen uptake, heart rate, sprinting time in defense, offense, fast breaks, and fast retreats, as well as ball velocity and jump height in the jump shot, were measured. RESULTS: Significant differences (P < .05) between under-23, under-19, under-17, and under-15 players were found for absolute peak oxygen uptake, defense, offense and fast break time, ball velocity, and jump height in the game-based performance test, as well as in body weight and height. CONCLUSION: The results revealed that with increasing age, elite male team handball players are heavier and taller (body weight and height); faster (team-handball offense, defense, and fast break); jump higher and throw faster (in the team-handball jump shot); and perform better aerobically (absolute peak oxygen uptake). The better performance in the under-23 and under-19 players compared with male adult players competing in a lower National Federation league (not on top-elite level) demonstrates that highly specific game-based physical performance determines the potential for developing young male team handball players for competition at the top level.

Assessment of the Maximal Range of Motion from Initial Sensation of Stretching to the Limits of Tolerance.

The aim of this study was to determine whether the first sensation of stretching (ROMFSS) may predict the maximum range of motion (ROMMAX) in male (N = 37) and female (N = 32) volunteer subjects, and to assess the reliability of the ROM perceived by subjects in relation to a pre-determined ROM (ROM50%). Subjects attempted three experimental sessions with 48 hours between sessions 1 and 2 and 28 days between sessions 1 and 3. Within each session, five trials were performed with isokinetic equipment to assess posterior thigh muscle flexibility. The results revealed a strong and significant correlation between ROMMAX and ROMFSS for both sexes, females (r = 0.96, p < 0.001, R2 = 0.92) and males (r = 0.91, p < 0.001; R2 = 0.82). The accuracy of the model verified by the standard error of estimate (SEE) was high in the equations proposed for both female (SEE = 4.53%) and male (SEE = 5.45%). Our results revealed that ROMFSS may predict the ROMMAX for both male and female subjects. The ROMFSS may contribute to the development of evaluation methods that do not subject the individuals to conditions that may include unnecessary risk of injury and is well suited to monitor the training process of stretching exercises with submaximal loads.

Testing-Specific Skating Performance in Ice Hockey.

ABSTRACT: Hajek, F, Keller, M, Taube, W, von Duvillard, SP, Bell, JW, and Wagner, H. Testing-specific skating performance in ice hockey. J Strength Cond Res 35(12S): S70-S75, 2020-Skating performance generally determines overall performance in ice hockey but has not been measured adequately in the past. Consequently, the aim of the study was to develop and validate a specific overall skating performance test for ice hockey (SOSPT) that includes similar movements and intensities as in competition. Ten male elite under-14-year and under-18-year old ice hockey players performed the SOSPT (2 heats only) and a 40-m on-ice sprinting test twice within 8 days. Additionally, 14 under-15, 18 under-17, and 20 under-20 male elite ice hockey players performed only the SOSPT (4 heats). Time was measured from the first subject's movement during a V-start until crossing the line (40-m on-ice sprinting test), first touch of the shoulder on the mat (heat #1 in the SOSPT) or first touch of the puck with the stick (heat #2 in the SOSPT) using a hand stopwatch. We found a high test-retest reliability of the SOSPT and 40-m on-ice sprinting test (interclass correlation coefficient, >0.7; coefficient of variation, <5%) with highly significant differences (p < 0.001) between the under-15, under-17, and under-20 players, a high correlation (r > 0.70) between an expert rating and the SOSPT, and a low correlation between the 40-m on-ice sprinting test and the SOSPT in the under-14 and under-18 players. The results of the study reveal that the SOSPT is a reliable and valid test to determine the specific overall skating performance in ice hockey players and is more suitable compared with straight skating tests of the 40-m on-ice sprinting test.

Effect of Differential Training on Female Volleyball Spike-Jump Technique and Performance.

PURPOSE: To determine the effect of in-season differential training on volleyball spike-jump technique and performance in elite-level female players. METHODS: During the season, spike jumps of 12 elite female players (Austrian Volleyball League Women) were recorded by 13 Qualisys Oqus cameras (250 Hz) and an AMTI force plate (1000 Hz). First measurement was made at the beginning of the investigation. Two identical measurements were repeated after a first and a second interval. The first interval served as control phase. The second interval was comparable in length and regular program but included differential training (6 wk, 8 sessions of 15-20 min) as a modified warm-up. It addressed specific performance determinants. Analyses of variances were calculated for the 3 measurements and for the development during control and intervention phase. RESULTS: Initial jump height (0.44 [0.09] m) changed by -4.5% during the control phase and +11.9% during the intervention (P < .001, ηp2=.70). All approach variables, arm backswing, and velocity-conversion strategy improved compared with the control phase (Δ%: 6.1-51.2%, P < .05, ηp2=.40-.80). Joint angles, countermovement depth, maximal angular velocities, and torso incline were not affected (Δ%: -2.9-9.1%, P = .066-.969, ηp2=.00-.27). CONCLUSIONS: In-season differential training led to technical adaptations and increased spike-jump height in elite female players. The differential training program allowed players to experience a range of adaptability and to adjust toward an individual optimum in technical components of performance determinants. Coaches are encouraged to apply technical differential training to elite athletes and to target biomechanical performance factors specifically.

Spike jump biomechanics in male versus female elite volleyball players.

There are well-known biological differences between women and men, especially in technical-coordinative variations that contribute to sex differences in performance of complex movements like the most important offensive action in volleyball, the spike jump. The aim of this study was to investigate sex-dependent performance and biomechanical characteristics in the volleyball spike jump. Thirty female and male sub-elite volleyball players were analysed while striking a stationary ball with maximal spike jump height. Twelve MX13 Vicon cameras with a cluster marker set, two AMTI force plates, surface EMG, and a Full-Body 3D model in Visual3D were used. Main findings include sex differences (P< .05) in jump height (pη2 = .73), approach [speed (pη2 = .61), step length], transition strategy [plant angle, neuromuscular activation (pη2 = .91), horizontal force maxima and impulses], acceleration distances [centre of mass displacement (pη2 = .21), minimal knee and hip angles], use of torso and arms [incline, angular velocity (pη2 = .23)]. Correlations support that the results cannot be explained fully by strength and power differences between sexes but represent the product of technical-coordinative variations. Their relevance is acknowledged for both sexes and numerous performance determinants displayed sex differences. The integration of such attributes into sex-specific training seems promising but its effect requires further investigation.

Testing Specific Physical Performance in Male Team Handball Players and the Relationship to General Tests in Team Sports.

Wagner, H, Sperl, B, Bell, JW, and von Duvillard, SP. Testing specific physical performance in male team handball players and the relationship to general tests in team sports. J Strength Cond Res 33(4): 1056-1064, 2019-Team handball is exemplified by frequent changes in intensities and different complex movements during games, whereas physical performance has often been tested predominantly using standardized general tests. The study aimed (a) to determine the relationship between specific and general physical performance as well as between specific aerobic capacity and agility, and (b) to ascertain the relevance of these tests for strength and conditioning professionals. Seventy-two male indoor court players performed a game-based performance test (GBPT) including team handball-specific techniques, upper-body and lower-body strength tests, a 30-m sprint test, a countermovement jump Abalakov (CMJA) test (with arm swing), and an incremental treadmill-running test. To assess the specific physical performance using the general test performance, we used linear regression calculations. In addition, a principal component factor analysis was calculated. Linear regression analyses revealed a low correlation (R < 0.5) between specific and general aerobic performance, 30-m sprinting time and specific agility in the GBPT, jump height in the CMJA test and jump height in the jump shot, as well as isokinetic shoulder rotation torque and ball velocity in the jump shot. However, a moderate correlation (R > 0.5) was found between specific aerobic performance and specific agility in the GBPT. Principal component factor analysis yielded separate components for specific and general physical performance with a cumulative variance of 69%. The results of this study clearly indicated that general and team handball-specific performance are separate components. Recommendations to strength and conditioning professionals and coaches in team handball were presented.

Movement characteristics of volleyball spike jump performance in females.

OBJECTIVES: Performance factors in the volleyball spike jump are well known for male players; however, technical-coordinative differences for female players are known only marginally. The objective of this study was to investigate the relationship between movement characteristics and female' spike jump performance and to identify the most relevant aspects of jump height and ball velocity. DESIGN: Single group correlation and regression. METHODS: Fifteen elite female volleyball players performed spike jumps by striking a stationary ball at maximal jump height. Data were collected via twelve MX13 Vicon cameras (250Hz), two AMTI force plates (2000Hz), and controlled via Visual3D software. RESULTS: Ten out of 42 characteristics correlated with jump height and none of 22 correlated with ball velocity. A stepwise regression model (adjusted R2=0.82, p<0.001) predicted jump height based on orientation step length and maximal angular velocity of dominant knee extension. For ball velocity, stepwise regression analysis was not feasible; however, an alternative model yielded adjusted R2=0.55, p<0.01. CONCLUSIONS: Key aspects for jump height were (1) optimised approach and energy conversion, (2) wide dynamic arm swing allowing for a forceful countermovement and, thus, increased range of motion in lower limbs, and (3) large angular velocities in ankles and knees, especially on the dominant side. These aspects strongly determined jump height in females and should be included in technical and strength-related training. For ball velocity, upper body anthropometrics and angular joint velocities emerged as the most important criteria. The importance of specific joints may depend on variations in striking technique.

Physical Performance in Elite Male and Female Team-Handball Players.

PURPOSE: Biological differences between men and women are well known; however, literature addressing knowledge about the influence of sex on specific and general performance in team handball is almost nonexistent. Consequently, the aim of the study was to assess and compare specific and general physical performance in male and female elite team-handball players, to determine if the differences are consequential for general compared with specific physical performance characteristics and the relationship between general and specific physical performance. METHODS: Twelve male and 10 female elite team-handball players performed a game-based performance test, upper- and lower-body strength and power tests, a sprinting test, and an incremental treadmill running test. RESULTS: Significant differences (P < .05) between male and female players were found for peak oxygen uptake and total running time during the treadmill test, 30-m sprinting time, leg-extension strength, trunk- and shoulder-rotation torque, and countermovement-jump height, as well as offense and defense time, ball velocity, and jump height in the game-based performance test. An interaction (sex × test) was found for time and oxygen uptake, and except shoulder-rotation torque and ball velocity in women, the authors found only a low relationship between specific and general physical performance. CONCLUSION: The results of the study revealed that male players are heavier, taller, faster, and stronger; jump higher; and have better aerobic performance. However, female players performed relatively better in the team-handball-specific tests than in the general tests. The findings also suggest that female players should focus more on strength training.

Specific physiological and biomechanical performance in elite, sub-elite and in non-elite male team handball players.

BACKGROUND: Team handball is a dynamic sport game that is played professionally in numerous countries. However, knowledge about training and competition is based mostly on practical experience due to limited scientific studies. Consequently, the aims of our study were to compare specific physiological and biomechanical performance in elite, sub-elite and in non-elite male team handball players. METHODS: Thirty-six elite, sub-elite and non-elite male team handball players performed a game based performance test, upper-body and lower-body strength tests, 30-m sprint test, counter movement jump test and an incremental treadmill running test. RESULTS: Significant differences (P<0.05) were found for the peak oxygen uptake, heart rate, offense and defense time, jump height and ball velocity during the jump throw in the game based performance test, maximal oxygen uptake in the incremental treadmill running test as well as in maximal leg strength and leg explosive strength in the isometric strength test. CONCLUSIONS: Elite male players have an enhanced specific agility, a better throwing performance, a higher team handball specific oxygen uptake and higher leg strength compared to sub-elite and non-elite players. Based on these results we recommend that training in team handball should focus on game based training methods to improve performance in specific agility, endurance and technique.

Specific Physical Training in Elite Male Team Handball.

Wagner, H, Gierlinger, M, Adzamija, N, Ajayi, S, Bacharach, DW, and von Duvillard, SP. Specific physical training in elite male team handball. J Strength Cond Res 31(11): 3083-3093, 2017-Specific physical training in elite team handball is essential for optimal player's performance; however, scientific knowledge is generally based on temporary training studies with subelite athletes. Therefore, the aim of the study was to analyze the effects of specific physical training in an elite male handball team over the entire season. Twelve players of a male handball team from the First Austrian Handball League conducted a 1-year specific physical training program in addition to their normal (team handball techniques and tactics) weekly training. Performance was measured with 5 general and 4 specific tests as well as game statistics during competition. Repeated measures analysis of variances and paired sample t-test were used to analyze differences in performance during training. We found a significant increase in oxygen uptake, offense time, defense time, fast break time, and jump height in the specific tests. Game performance statistics revealed a lower throwing percentage in the hosting team (59%) compared with the rival teams (63%). Our results indicated that specific endurance and agility are an acceptable modality in elite male team handball. However, performance in competition is strongly influenced by specific techniques and tactics. We recommend to strength and conditioning professionals that they tailor strength and power training, coordination and endurance as specific as possible, using free weights, agility exercises that include change in direction and jumps as well as short (10-15 seconds) high-intensity intervals.

Effects of Dual-Task Management and Resistance Training on Gait Performance in Older Individuals: A Randomized Controlled Trial.

Background: Dual-task (DT) training is a well-accepted modality for fall prevention in older adults. DT training should include task-managing strategies such as task switching or task prioritization to improve gait performance under DT conditions. Methods: We conducted a randomized controlled trial to evaluate a balance and task managing training (BDT group) in gait performance compared to a single task (ST) strength and resistance training and a control group, which received no training. A total of 78 older individuals (72.0 ± 4.9 years) participated in this study. The DT group performed task managing training incorporating balance and coordination tasks while the ST group performed resistance training only. Training consisted of 12 weekly sessions, 60 min each, for 12 weeks. We assessed the effects of ST and BDT training on walking performance under ST and DT conditions in independent living elderly adults. ST and DT walking (visual verbal Stroop task) were measured utilizing a treadmill at self-selected walking speed (mean for all groups: 4.4 ± 1 km h-1). Specific gait variables, cognitive performance, and fear of falling were compared between all groups. >Results: Training improved gait performance for step length (p < 0.001) and gait-line (ST: p < 0.01; DT p < 0.05) in both training groups. The BDT training group showed greater improvements in step length (p < 0.001) and gait-line (p < 0.01) during DT walking but did not have changes in cognitive performance. Both interventions reduced fear of falling (p < 0.05). Conclusion: Implementation of task management strategies into balance and strength training in our population revealed a promising modality to prevent falls in older individuals. Trial registration: German register of clinical trials DRKS00012382.

Saving your back: How do horizontal patient transfer devices stack up?

The authors evaluated the use of a new transfer device (roller tray) and compared it with three commonly used devices (slide board, nylon tube, and roller board). Caregivers experienced the greatest low back stress moving patients weighing 70 to 90 kg (approximately 150 to 200 lb). Qualitative data overwhelmingly favored the new roller tray with disposable absorbent underpads over the other devices. Caregivers experienced the greatest L4-5 torque not when transferring the heaviest patients (over 90 kg or approximately 200 lb), but rather when transferring those weighing 70 to 90 kg. These "middle-weight" patients are often moved using only two instead of three caregivers or a lift team, as are used for heavier patients. Caregivers should use three caregivers (two pullers and one pusher) even when patients are medium weight. The researchers' nursing faculty members are enthusiastic about using the new transfer device in their teaching stations.

Testing Game-Based Performance in Team-Handball.

Wagner, H, Orwat, M, Hinz, M, Pfusterschmied, J, Bacharach, DW, von Duvillard, SP, and Müller, E. Testing game-based performance in team-handball. J Strength Cond Res 30(10): 2794-2801, 2016-Team-handball is a fast paced game of defensive and offensive action that includes specific movements of jumping, passing, throwing, checking, and screening. To date and to the best of our knowledge, a game-based performance test (GBPT) for team-handball does not exist. Therefore, the aim of this study was to develop and validate such a test. Seventeen experienced team-handball players performed 2 GBPTs separated by 7 days between each test, an incremental treadmill running test, and a team-handball test game (TG) (2 × 20 minutes). Peak oxygen uptake (V[Combining Dot Above]O2peak), blood lactate concentration (BLC), heart rate (HR), sprinting time, time of offensive and defensive actions as well as running intensities, ball velocity, and jump height were measured in the game-based test. Reliability of the tests was calculated using an intraclass correlation coefficient (ICC). Additionally, we measured V[Combining Dot Above]O2peak in the incremental treadmill running test and BLC, HR, and running intensities in the team-handball TG to determine the validity of the GBPT. For the test-retest reliability, we found an ICC >0.70 for the peak BLC and HR, mean offense and defense time, as well as ball velocity that yielded an ICC >0.90 for the V[Combining Dot Above]O2peak in the GBPT. Percent walking and standing constituted 73% of total time. Moderate (18%) and high (9%) intensity running in the GBPT was similar to the team-handball TG. Our results indicated that the GBPT is a valid and reliable test to analyze team-handball performance (physiological and biomechanical variables) under conditions similar to competition.

Physiological Demands of Simulated Off-Road Cycling Competition.

The purpose of the study was to measure the demands of off-road cycling via portable spirometry, leg-power output (PO), heart rate (HR) and blood lactate (BLa) concentration. Twenty-four male competitive cyclists (age: 29±7.2 yrs, height: 1.79 ± 0.05 m, body mass: 70.0 ± 4.9 kg, VO2peak: 64.9 ± 7.5 ml·kg(-1)·min(-1)) performed simulated mountain bike competitions (COMP) and laboratory tests (LabT). From LabT, we determined maximal workload and first and second ventilatory thresholds (VT1, VT2). A high-performance athlete (HPA) was used for comparison with three groups of subjects with different sport-specific performance levels. Load profiles of COMP were also investigated during uphill, flat and downhill cycling. During the COMP, athletes achieved a mean oxygen uptake (VO2COMP) of 57.0 ± 6.8 ml·kg(-1)·min(-1) vs. 71.1 ml·kg(-1)·min(-1) for the HPA. The POCOMP was 2.66±0.43 W·kg(-1) and 3.52 W·kg(-1) for the HPA. POCOMP, VO2COMP and HRCOMP were compared to corresponding variables at the VT2 of LabT. LabT variables correlated with racing time (RTCOMP) and POCOMP (p < 0.01 to <0.001; r-0.59 to -0.80). The VO2peak (LabT) accounted for 65% of variance of a single COMP test. VO2COMP, POCOMP and also endurance variables measured from LabTs were found as important determinants for cross-country performance. The high average VO2COMP indicates that a high aerobic capacity is a prerequisite for successful COMP. Findings derived from respiratory gas measures during COMPs might be useful when designing mountain bike specific training. Key pointsCross- country cycling is characterized by high oxygen costs due to the high muscle mass simultaneously working to fulfill the demands of this kind of sports.Heart rate and blood lactate concentration measures are not sensitive enough to assess the energy requirements of COMP. Therefore, respiratory gas and power output measures are helpful to provide new information to physiological profile of cross- country cycling.An excellent cycling-specific capacity is a prerequisite for successful off-road cycling.Data determined from LabT might be utilized to describe semi-specific abilities of MB- athletes on a cycle ergometer, while data originating from COMP might be useful when designing a mountain bike specific training.

Individual and team performance in team-handball: a review.

Team handball is a complex sport game that is determined by the individual performance of each player as well as tactical components and interaction of the team. The aim of this review was to specify the elements of team-handball performance based on scientific studies and practical experience, and to convey perspectives for practical implication. Scientific studies were identified via data bases of PubMed, Web of Knowledge, SPORT Discus, Google Scholar, and Hercules. A total of 56 articles met the inclusion criteria. In addition, we supplemented the review with 13 additional articles, proceedings and book sections. It was found that the specific characteristics of team-handball with frequent intensity changes, team-handball techniques, hard body confrontations, mental skills and social factors specify the determinants of coordination, endurance, strength and cognition. Although we found comprehensive studies examining individual performance in team-handball players of different experience level, sex or age, there is a lack of studies, particularly for team-handball specific training, as well as cognition and social factors. Key PointsThe specific characteristics of team-handball with frequent intensity changes, specific skills, hard body confrontations, mental skills and social factors define the determinants of coordination, endurance, strength and cognition.To increase individual and team performance in team-handball specific training based on these determinants have been suggested.Although there are comprehensive studies examining individual performance in team-handball players of different experience level, sex, or age are published, there is a lack of training studies, particularly for team-handball specific techniques and endurance, as well as cognition and social factors.

Myocardial dimensions and hemodynamics during 24-h ultraendurance ergometry.

PURPOSE: This study aimed to evaluate cardiorespiratory and hemodynamic responses during 24 h of continuous cycle ergometry in ultraendurance athletes. METHODS: Eight males (mean ± SD; age = 39 ± 8 yr, height = 179 ± 7 cm, body weight [Wt] = 77.1 ± 6.0 kg) were monitored during 24 h at a constant workload,∼25% below the first lactate turn point at 162 ± 23 W. Measurements included Wt, HR, oxygen consumption (V˙O2), cardiac output (Q), and stroke volume (SV) determined by a noninvasive rebreathing technique (Innocor; Innovision, Odense, Denmark). Myocardial dimensions were evaluated using a two-dimensional echocardiogram. [M-mode measurement]-left atrial (LAD), ventricular end-diastolic (LVEDD), and end-systolic diameters (LVESD) were obtained over the left parasternal area. Venous blood samples were analyzed for hematocrit (Hct%), albumin (g·L(-1)), aldosterone (pg·mL(-1)), CK, CK-MB (U·L(-1)), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (pg·mL(-1)). RESULTS: HR (bpm) significantly increased (P < 0.01) from 1 h (132 ± 11) to 6 h (143 ± 10) and significantly decreased (P < 0.001) from 6 to 24 h (116 ± 10). V˙O2 and (Q were unchanged during the 24 h. Wt (76.6 ± 5.6 vs 78.7 ± 5.4), SV (117 ± 13 vs 148 ± 19), LVEDD (4.9 ± 0.3 vs 5.6 ± 0.2), and LAD (3.6 ± 0.5 vs 4.3 ± 0.7) significantly increased between 6 and 24 h (P < 0.001). No significant changes were observed for LVESD. Hct (45.1 ± 1.3 vs 41.3 ± 1.2) significantly decreased (P < 0.05) and CK (181 ± 60/877 ± 515), aldosterone (48 ± 17 vs 661 ± 172), and NT-proBNP (23 ± 13 vs 583 ± 449) significantly increased (P < 0.05). The increase in SV (ΔSV) was significantly related to changes in Wt (ΔWt), and HR (ΔHR) and ΔWt were significantly related to ΔLAD and ΔLVEDD. CONCLUSION: Our findings suggest that the decrease in HR during 24 h of ultraendurance exercise was due to hypervolemia and the associated ventricular loading, increasing left ventricular diastolic dimensions because of increased SV and LVEDD, resulting in an increase in NT-proBNP.

Energy expenditure and sex differences of golf playing.

The purpose of the study was to assess the average physical intensity and energy expenditure during a single round of golf on hilly and flat courses in a heterogeneous group of healthy men and women of varying age and golf handicap. Forty-two males and 24 females completed an incremental cycle-ergometer exercise test to determine exercise performance markers. The heart rate (HR), duration, distance, walking speed, ascent and descent were measured via a global positioning system (GPS)/HR monitor during the game and energy expenditure was calculated. Playing 9 or 18-holes of golf, independent of the golf course design, the average HR was not significantly different between sexes or the subgroups. The intensities were light with respect to the percentage of maximal HR and metabolic equivalents of task (METs). Total energy expenditure of all participants was not significantly different for hilly (834 ± 344 kcal) vs. flat courses (833 ± 295 kcal) whereas male players expended significantly greater energy than female players (926 ± 292 vs. 556 ± 180 kcal), but did not have significantly greater relative energy expenditure (2.8 ± 0.8 vs. 2.2 ± 0.7 METs). As a high volume physical activity, playing golf is suggested to yield health benefits. Since the intensity was well below recommended limits, golf may have health related benefits unrelated to the intensity level of the activity.

Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis.

UNLABELLED: Arachidonic acid (AA) is metabolized to eicosanoids and isoprostanes (IPs) via different pathways. The presence of granuloma in apical periodontitis (AP) is linked with inflammation and the synthesis of metabolites of AA. OBJECTIVE: We investigated the conversion rate of (14)C labelled arachidonic acid ((14)C-AA), the lipoxygenases (LOX) products and the endogenous synthesis of eicosanoids and IPs in extracted granuloma. Furthermore, we assessed if there are markers for bone destruction and the influence of cigarette smoking. PATIENTS AND METHODS: In 46 patients with symptoms and corresponding radiological signs of AP, teeth were extracted including the periapical granuloma. The endogenous synthesis of eicosanoids and IPs, the conversion rate of (14)C-AA and LOX products in extracted granuloma were analyzed. RESULTS: We found that smoking increases significantly the synthesis of IPs and LOX-metabolites in granuloma. Furthermore, smoking may have contributed to significant differences in qualitative and quantitative profile of eicosanoids, IPs and the conversion rate of (14)C-AA independent of the size of the granuloma. CONCLUSIONS: Our data demonstrate that in smokers with granuloma due to AP products of lipid peroxidation as 8-iso-PGF(2α) and products of the LOX-pathway are increased at the expense of cyclooxygenase products. The size of granuloma did not influence the amount of synthesized eicosanoids, IPs or LOX-metabolites out of (14)C-AA whereas cigarette smoking was a significantly influencing and modifiable risk factor.