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Int J Occup Saf Ergon ; 26(1): 46-54, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29583088


A pair of lightweight electrically heated gloves (EHG) with smart temperature control function was developed. To evaluate the thermoregulation properties of the EHG, human trials were conducted in a climate chamber (2.5 °C, 60% RH). The changes in skin temperature at all fingers and the opisthenar, and the subjective thermal sensation were recorded over 60 min. The effects of two air velocities (i.e., 0.17 and 0.50 m/s) on the cold protective performance of the EHG in scenarios of heating and control were also investigated. For heating scenarios, skin temperature and thermal sensation at all fingers and the opisthenar were found significantly higher than those in control conditions. Moreover, the air velocity at 0.50 m/s greatly reduced the cold protective performance of the gloves. The research findings can be applied to improve thermal comfort and extend working times for persons in cold environments.

Luvas Protetoras , Calefação/métodos , Termorreceptores , Sensação Térmica , Feminino , Humanos , Masculino , Temperatura Cutânea , Fatores de Tempo , Adulto Jovem
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 37(2): 190-6, 2012 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-22561438


OBJECTIVE: To investigate the expression of galectin-1 with the stimulation of peritoneal dialysis solution (PDS) and its role in the epithelial-to-mesenchymal transition (EMT) in human peritoneal mesothelial cells (HPMCs). METHODS: HPMCs were stimulated with PDS containing different concentrations of high glucose (1.5%, 2.5%, and 4.25%). After 24 h, mRNA and protein expressions of galectin-1,vimentin, and zo-1 were analyzed with real-time PCR and Western blot, respectively. Liposome transfected siRNA technique was used to knock down the expression of galectin-1 and the effect of galectin-1 siRNA on the EMT of HPMCs was also observed under 4.25% PDS condition. RESULTS: mRNA expression of galectin-1 in HPMCs increased in PDS groups, especially in group with 4.25% PDS (P<0.05). Protein expression of galectin-1 in HPMCs significantly increased in PDS groups with a dose dependent manner (P<0.05).Expression of vimentin in HPMCs significantly increased in PDS groups, especially in groups of 2.5% PDS and 4.25% PDS (P<0.05), but zo-1 expression markedly decreased (P<0.05). The expression of galectin-1 correlated positively with vimentin (P<0.05) but negatively with zo-1 (P<0.05). Expression of vimentin in groups of 4.25% PDS was markedly inhibited (P<0.05) by galectin-1 siRNA, whereas zo-1 expression was significantly increased (P<0.05). CONCLUSION: Galectin-1 can mediate high glucose PDS-induced EMT in HPMCs and may be a new target for the prevention and treatment of peritoneal fibrosis.

Soluções para Diálise/farmacologia , Transição Epitelial-Mesenquimal/efeitos dos fármacos , Galectina 1/metabolismo , Glucose/farmacologia , Peritônio/citologia , Células Cultivadas , Células Epiteliais/citologia , Galectina 1/genética , Humanos , Diálise Peritoneal/efeitos adversos , Fibrose Peritoneal/etiologia , RNA Mensageiro/genética , RNA Mensageiro/metabolismo