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Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-38110150


INTRODUCTION: Shoulder calcific tendinopathy is a frequent cause of shoulder pain. Diagnosis is usually based on ultrasound (US) and/or X-ray. US is considered an inherently operator-dependent imaging modality and, interobserver variability has previously been described by experts in the musculoskeletal US. The main objective of this study is to assess the interobserver agreement for shoulder calcific tendinopathy attending to the size, type, and location of calcium analyzed in plain film and ultrasound among trained musculoskeletal radiologists. MATERIAL AND METHODS: From June 2018 to May 2019, we conducted a prospective study. Patients diagnosed with shoulder pain related to calcific tendinopathy were included. Two different experienced musculoskeletal radiologists evaluated independently the plain film and the US. RESULTS: Forty patients, with a mean age of 54.6 years, were included. Cohen's kappa coefficient of 0.721 and 0.761 was obtained for the type of calcium encountered in plain film and the US, respectively. The location of calcification obtained a coefficient of 0.927 and 0.760 in plain film and US, respectively. The size of the calcification presented an intraclass correlation coefficient (ICC) of 0.891 and 0.86 in plain film and US respectively. No statistically significant differences were found in either measurement. CONCLUSION: This study shows very good interobserver reliability of type and size measurement (plain film and US) of shoulder calcifying tendinopathy in experienced musculoskeletal radiologists.

Signal Transduct Target Ther ; 8(1): 405, 2023 10 25.
Artigo em Inglês | MEDLINE | ID: mdl-37875500


Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK inhibitors. Preclinical investigators of this study found that CDK4 overexpression, while not of CDKN2A, was the most consistent predictive factor for palbociclib efficacy in sarcomas. Advanced adult-type soft-tissue sarcoma, excluding DD-LPS, or bone sarcoma patients, progressing after at least one systemic line, whose tumors overexpressed CDK4, but not CDKN2A at baseline biopsy, were accrued in this single-arm phase II trial (EudraCT number: 2016-004039-19). With the main endpoint of a 6-month PFS rate, 40% was considered promising in this population. Palbociclib was administered orally at 125 mg/day for 21 days in 28-day cycles. A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening, archival material (141), and screening, baseline biopsy (95). There were 28 (29%) with favorable mRNA profiles from 95 screened patients at baseline. From 23 enrolled patients, 21 evaluable, the 6-month PFS rate was 29% (95% CI 9-48), and there were 6 patients out of 21 with a PFS longer than 6 months. The median PFS and overall survival were 4.2 (95% CI 3.6-4.8) and 12 (95% CI 8.7-15.4) months, respectively. Translational research showed a significant correlation between CDK4 mRNA and protein expression. Palbociclib was active in a variety of sarcoma subtypes, selected by CDK4/CDKN2A, and deserves further investigation in the sarcoma context.

Lipopolissacarídeos , Sarcoma , Adulto , Humanos , Sarcoma/genética , Piperazinas/uso terapêutico , Piperazinas/farmacologia , RNA Mensageiro , Quinase 4 Dependente de Ciclina/genética , Inibidor p16 de Quinase Dependente de Ciclina/genética , Inibidor p16 de Quinase Dependente de Ciclina/metabolismo
Rev. colomb. reumatol ; 28(3): 218-220, jul.-set. 2021. graf
Artigo em Espanhol | LILACS | ID: biblio-1357274


RESUMEN La tendinopatía calcificada del hombro se caracteriza por el depósito de cristales de hidroxiapatita en uno o varios tendones del hombro. Dentro de los procesos que ocurren en esta entidad está la fase de reabsorción, en la que los depósitos podrían migrar hacia estructuras adyacentes. Una muy rara complicación es la migración hacia la unión miotendinosa del tendón correspondiente, la cual provoca una importante reacción inflamatoria muscular que puede objetivarse en pruebas complementarias específicas. Presentamos un caso clínico de una tendinopatía calcificante del subescapular, con pos terior migración hacia la unión miotendinosa causando una miositis del mismo.

ABSTRACT Calcific tendinopathy of the shoulder is characterised by the deposit of hydroxy apatite crys tals in one or more tendons of the shoulder. Within the processes that occur within this disorder, there is the resorption phase, in which the deposits could migrate towards adjacent structures. A very rare complication is the migration towards the myotendinous junction of the corresponding tendon, which causes a significant muscular inflammatory reaction that can be seen in specific complementary tests. A clinical case is presented of a subscapular calcific tendinopathy, with subsequent migra tion to the myotendinous junction, causing myositis of the same.

Humanos , Feminino , Pessoa de Meia-Idade , Condições Patológicas, Sinais e Sintomas , Doenças Musculoesqueléticas , Senilidade Prematura , Edema , Tendinopatia , Doenças Musculares
J Ultrason ; 21(85): e177-e181, 2021 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-34258044


We report the case of a 19-year-old professional volleyball player who presented with right shoulder pain exacerbated during sports activity. On physical examination, infraspinatus atrophy was evident. As the clinical setting suggested suprascapular nerve entrapment syndrome, shoulder MR and later CT were performed. The results showed radiological signs of subacute-chronic infraspinatus muscle denervation and a Bennett lesion of the shoulder, presumably due to chronic repetitive trauma during the classical overhead swing in volleyball. The patient agreed to surgical treatment, and arthroscopic decompression was achieved. After months of rehabilitation, the pain gradually subsided, the infraspinatus muscle recovered its trophism, and the patient progressively returned to her regular sports activity.

J Shoulder Elbow Surg ; 29(1): 104-112, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31409562


BACKGROUND: Subscapularis function after arthroscopic Bankart repair has been widely studied. However, data regarding subscapularis performance after arthroscopic Latarjet procedures are lacking. This study aimed to evaluate subscapularis clinical and radiologic performance after arthroscopic Latarjet procedures. METHODS: We included 40 patients who underwent arthroscopic Latarjet procedure with a minimum 2-year follow-up. Clinical evaluation included Western Ontario Shoulder Instability Index and Rowe scores, specific subscapularis isokinetic study, and lift-off tests. Contralateral measurements were used for comparison. Computed tomographic evaluation included graft consolidation, muscle dimensions, and degree of fatty atrophy, calculated as the mean muscle attenuation (MMA). RESULTS: There was a decrease of 8.3% of maximum internal rotation peak torque in the operated arm (P = .02). However, there was no significant difference in the agonist-antagonist ratio: 76.9% in the operated arm and 76% in the contralateral (P = .82). Lift-off strength test demonstrated a decrease in the first year but not at final follow-up (P = .38). There was a significant decrease in lift-off distance of 23% compared to the contralateral side (P < .001). Subscapularis MMA was diminished when compared to the infraspinatus/teres minor (P < .001) at the expense of its upper part (P = .03). Hyperlaxity and number of dislocation episodes were correlated to a lower MMA (P = .046 and P = .005). CONCLUSION: Arthroscopic Latarjet procedures provide satisfactory clinical results. There seems to be a diminished subscapularis MMA depending on its superior half. Hyperlaxity and number of previous dislocations were correlated to a lower MMA. Although there was a decrease in the maximum internal rotation peak torque, we did not find any difference in the agonist-antagonist ratio or in the final lift-off strength between sides.

Instabilidade Articular/cirurgia , Manguito Rotador/fisiopatologia , Luxação do Ombro/cirurgia , Articulação do Ombro/fisiopatologia , Adolescente , Adulto , Artroplastia/métodos , Artroscopia , Feminino , Seguimentos , Humanos , Instabilidade Articular/fisiopatologia , Masculino , Força Muscular , Estudos Prospectivos , Rotação , Manguito Rotador/diagnóstico por imagem , Luxação do Ombro/fisiopatologia , Articulação do Ombro/cirurgia , Tomografia Computadorizada por Raios X , Adulto Jovem
Hand (N Y) ; 12(5): NP136-NP139, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28391751


BACKGROUND: Amyloidosis affecting peripheral nerve is usually seen in primary amyloidosis. METHODS: We are reporting on the case of a 74-year-old man with a 16-month history of progressive left radial nerve paralysis. Perioperative imaging detected an enlarged radial nerve in the middle-distal part of the arm. The patient had an antecedent of amyloid deposits in the lung. RESULTS: A radial nerve amyloidosis was suspected and confirmed with a biopsy assisted by ultrasonography, resulting in a secondary amyloidosis form. CONCLUSIONS: Isolated radial nerve palsy due to nerve damage by amyloidosis has been reported before, but not in AA or secondary amyloidosis.

Amiloidose/diagnóstico , Nervo Radial/patologia , Neuropatia Radial/etiologia , Idoso , Biópsia , Humanos , Masculino , Nervo Radial/diagnóstico por imagem
Opt Express ; 19 Suppl 2: A136-45, 2011 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-21445215


Restricting the angular range in which a photovoltaic system emits light, is a promising but rather unexplored approach to enhance conversion efficiency. In this paper we analyze and discuss the effect of a directionally selective filter on the absorption of light and the generation of charge carriers in a germanium solar cell. A directionally selective filter transmits photons of perpendicular incidence and reflects photons under oblique incidence in a given spectral range. To investigate its effect on light trapping, we perform reflection and quantum efficiency measurements. The reflection measurements show that a wavelength dependent absorption enhancement is induced by the application of the directionally selective filter. We calculate a maximum absorption enhancement of 45% at λ ≈ 1900 nm. We show that the absorption enhancement is caused by light trapping of non-absorbed and scattered light and is not due to a suppression of radiative processes. A trapping of photons generated by radiative recombination could not be detected. Measurements of the quantum efficiency confirm the results of the reflection measurements. The generation of charge carriers is increased by up to 33% at λ ≈1900 nm. A comparison of path length enhancement factors calculated from reflection and quantum efficiency measurements indicates a low parasitic absorption in the solar cell device.

Emerg Radiol ; 18(2): 177-80, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21057844


Remote cerebellar hemorrhage (RCH) is a rare complication after supratentorial or spinal surgery. RCH is poorly known and hence probably underdiagnosed. Diminished consciousness and headache are the most common clinical features. Computed tomography and magnetic resonance reveal a characteristic pattern of linear bleeding between the cerebellar folia. The pathophysiological mechanism is disputed but is probably venous bleeding secondary to significant intraoperative or postoperative loss of cerebrospinal fluid. Multiple risk factors have been described, but postsurgical negative pressure drainage of cerebrospinal fluid is the only clearly predisposing factor. We present a case of RCH after spinal surgery with a literature review.

Hemorragia Cerebral/diagnóstico , Região Lombossacral , Feminino , Humanos , Região Lombossacral/cirurgia , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Tomografia Computadorizada por Raios X
Asunción; s.e; 2010.Oct. 39 p. ilus, graf.
Monografia em Espanhol | LILACS, BDNPAR | ID: biblio-1018565


Los dientes homólogos tienen la misma anatomía, corresponden a una misma arcada, diferenciándose en derecho e izquierdo. Se forman en la misma etapa de la vida del individuo. Están expuestos a los mismos factores durante su formación, pudiendo sufrir alteraciones estructurales idénticas que los hace susceptibles en un mismo grado a los factores exógenos. Los dientes temporarios evidencian un rápido avance de caries aparentemente porque, a diferencia de los permanentes, aquellos presentan menor grosor del esmalte por lo que los microorganismo rápidamente invaden dentina; además, tienen una vida útil relativamente corta. Se realizó un estudio observacional descriptivo de corte transversal en 101 niños con dentición temporaria y mixta temprana que acudieron a la Facultad de odontología de la Universidad Nacional de Asunción durante el año 2009 con el objetivo de determinar la frecuencia de caries en molares temporarios homólogos. Par ello se realizó un control clínico y radiográfico a fin de llegar al objetivo. Mediante la exploración clínica se observó que los 101 niños, 98 (97) presentaron caries de ubicación similar en por lo menos 1 un par de molares homólogos. Deben tomarse medidas preventivas cuando se presentan en la clínica pacientes con un molar temporario afectado ya que la probabilidades de que el molar homólogo esté afectado son bastante altas .

Humanos , Cárie Dentária , Homologação , Odontologia