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1.
Artigo em Inglês | MEDLINE | ID: mdl-35040057

RESUMO

Boron (B) has previously been shown to inhibit cadmium (Cd) uptake in wheat. Here, we investigated the physiological response of external B application (C for no B added, B for B added, B+Cd for B and Cd added, B/Cd for B 24 h pretreatment before Cd added, B and Cd were 46.2 µM and 5 µM, respectively) on wheat growth under Cd stress. The results showed that the wheat growth was significantly weaker under Cd treatment, while B application did not significantly improve the wheat growth under Cd stress. However, B application decreased Cd concentrations and malondialdehyde (MDA) concentrations of shoot and root. The key enzyme activities including superoxide dismutase (SOD) and peroxidase (POD) significantly increased under Cd treatments while decreased under B treatments. Further, a total of 198, 680 and 204 of the differential metabolites were isolated between B and C treatment, Cd and C treatment and B+Cd and Cd treatment, respectively. The metabolites with up-accumulation in B application (B+Cd) roots were mainly galactaric acid, citric acid, N6-galacturonyl-L-lysine, D-glucose, while the metabolites with down-accumulation were mainly threoninyl-tryptophan and C16 sphinganine. The differential metabolic pathways were mainly concentrated in linoleic acid metabolism, galactose metabolism, sphingolipid metabolism, glycolysis/gluconeogenesis, propanoate metabolism in diabetic complications between B+Cd treatment and B treatment. The results indicate that B alleviates Cd toxicity in winter wheat by inhibiting Cd uptake, increasing antioxidant enzyme activity and changing metabolites.

2.
J Pharm Biomed Anal ; 210: 114565, 2022 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-35033944

RESUMO

Andrographis paniculata (Burm.f.) Nees is an essential traditional herbal medicine with various bioactivities in Asian countries. The quality of herbal medicines directly affects its clinical efficacy, so a comprehensive strategy, including color assay, chemical profiles, quantitative analysis, and anti-inflammatory activity assay, is constructed to evaluate the quality of A. paniculata in this paper. Here, 16 batches of commercial A. paniculata were collected, and there were noticeable differences in appearance, chemical compounds, and bioactivity among batches. Principal component analysis (PCA) indicated the color and diterpenoid lactones could be used to classify A. paniculat. And then, correlation analysis found the batches with greener color have higher contents of diterpenoid lactones and more efficient anti-inflammatory activity. Based on the results above, the partial least squares (PLS) regression models were finally established to predict the contents of diterpenoid lactones using the color assay data. All diterpenoid lactones models showed good performance, especially neoandrographolide. Notably, PLS regression models were first used for the nondestructive quantitative analysis of A. paniculata. This comprehensive quality evaluation strategy can theoretically elucidate the relationship between good appearance, high contents of diterpenoid lactones, and superior bioactivity of A. paniculata, which is meaningful for its quality control and evaluation. It also laid a theoretical basis for appearance and bioactivity evaluations of high-quality traditional herbal medicine.

3.
Glob Health Action ; 15(1): 1987044, 2022 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-35037844

RESUMO

To achieve universal health coverage, health system strengthening (HSS) is required to support the of delivery of high-quality care. The aim of the National Institute for Health Research Global Research Unit on HeAlth System StrEngThening in Sub-Saharan Africa (ASSET) is to address this need in a four-year programme, with three healthcare platforms involving eight work-packages. Key to effective health system strengthening (HSS) is the pre-implementation phase of research where efforts focus on applying participatory methods to embed the research programme within the existing health system. To conceptualise the approach, we provide an overview of the key methods applied across work-package to address this important phase of research conducted between 2017 and 2021.Work-packages are being undertaken in publicly funded health systems in rural and urban areas in Ethiopia, Sierra Leone, South Africa, and Zimbabwe. Stakeholders including patients and their caregivers, community representatives, clinicians, managers, administrators, and policymakers are the main research participants.In each work-package, initial activities engage stakeholders and build relationships to ensure co-production and ownership of HSSIs. A mixed-methods approach is then applied to understand and address determinants of high-quality care delivery. Methods such as situation analysis, cross-sectional surveys, interviews and focus group discussions are adopted to each work-package aim and context. At the end of the pre-implementation phase, findings are disseminated using focus group discussions and participatory Theory of Change workshops where stakeholders from each work package use findings to select HSSIs and develop a programme theory.ASSET places a strong emphasis of the pre-implementation phase in order to provide an in-depth and systematic diagnosis of the existing heath system functioning, needs for strengthening and stakeholder engagement. This common approach will inform the design and evaluation of the HSSIs to increase effectiveness across work packages and contexts, to better understand what works, for whom, and how.

4.
BMC Anesthesiol ; 22(1): 14, 2022 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-34996367

RESUMO

BACKGROUND: Serum chloride (Cl-) is one of the most essential extracellular anions. Based on emerging evidence obtained from patients with kidney or heart disease, hypochloremia has been recognized as an independent predictor of mortality. Nevertheless, excessive Cl- can also cause death in severely ill patients. This study aimed to investigate the relationship between hyperchloremia and high mortality rate in patients admitted to the surgical intensive care unit (SICU). METHODS: We enrolled 2131 patients from the Multiparameter Intelligent Monitoring in Intensive Care III database version 1.4 (MIMIC-III v1.4) from 2001 to 2012. Selected SICU patients were more than 18 years old and survived more than 72 h. A serum Cl- level ≥ 108 mEq/L was defined as hyperchloremia. Clinical and laboratory variables were compared between hyperchloremia (n = 664) at 72 h post-ICU admission and no hyperchloremia (n = 1467). The Locally Weighted Scatterplot Smoothing (Lowess) approach was utilized to investigate the correlation between serum Cl- and the thirty-day mortality rate. The Cox proportional-hazards model was employed to investigate whether serum chlorine at 72 h post-ICU admission was independently related to in-hospital, thirty-day and ninety-day mortality from all causes. Kaplan-Meier curve of thirty-day and ninety-day mortality and serum Cl- at 72 h post-ICU admission was further constructed. Furthermore, we performed subgroup analyses to investigate the relationship between serum Cl- at 72 h post-ICU admission and the thirty-day mortality from all causes. RESULTS: A J-shaped correlation was observed, indicating that hyperchloremia was linked to an elevated risk of thirty-day mortality from all causes. In the multivariate analyses, it was established that hyperchloremia remained a valuable predictor of in-hospital, thirty-day and ninety-day mortality from all causes; with adjusted hazard ratios (95% CIs) for hyperchloremia of 1.35 (1.02 ~ 1.77), 1.67 (1.28 ~ 2.19), and 1.39 (1.12 ~ 1.73), respectively. In subgroup analysis, we observed hyperchloremia had a significant interaction with AKI (P for interaction: 0.017), but there were no interactions with coronary heart disease, hypertension, and diabetes mellitus (P for interaction: 0.418, 0.157, 0.103, respectively). CONCLUSION: Hyperchloremia at 72 h post-ICU admission and increasing serum Cl- were associated with elevated mortality risk from all causes in severely ill SICU patients.

5.
Nat Commun ; 13(1): 138, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-35013412

RESUMO

Molecularly soft organic-inorganic hybrid perovskites are susceptible to dynamic instabilities of the lattice called octahedral tilt, which directly impacts their carrier transport and exciton-phonon coupling. Although the structural phase transitions associated with octahedral tilt has been extensively studied in 3D hybrid halide perovskites, its impact in hybrid 2D perovskites is not well understood. Here, we used scanning tunneling microscopy (STM) to directly visualize surface octahedral tilt in freshly exfoliated 2D Ruddlesden-Popper perovskites (RPPs) across the homologous series, whereby the steric hindrance imposed by long organic cations is unlocked by exfoliation. The experimentally determined octahedral tilts from n = 1 to n = 4 RPPs from STM images are found to agree very well with out-of-plane surface octahedral tilts predicted by density functional theory calculations. The surface-enhanced octahedral tilt is correlated to excitonic redshift observed in photoluminescence (PL), and it enhances inversion asymmetry normal to the direction of quantum well and promotes Rashba spin splitting for n > 1.

7.
Artigo em Inglês | MEDLINE | ID: mdl-35023236

RESUMO

Melatonin has been reported to affect intestinal function by targeting microbiome, morphological structure, barrier integrity and nutrient absorptive system. While the effect of melatonin on intestinal development in newborn infants is obscure, thus, this study firstly attempted to investigate the hypothesis that melatonin treatment improves intestinal development in sucking piglets. 14 healthy newborn piglets received 10 ml melatonin solution (1 mg/ml) or drinking water (n = 7) for 21 days. The results showed that oral administration of melatonin increased liver relative weight (p < 0.05) but failed to affect growth performance in sucking piglets (p > 0.05). Immunostaining jejunal samples from melatonin group showed high expressions of nnos and claudin1, indicating that melatonin improved intestinal neural development and barrier integrity. Also, melatonin promoted intestinal absorptive function evidenced by the increased serum proline concentration in melatonin-treated piglets compared with the control (p < 0.05). Gut microbiota compositions were tested by 16S rDNA sequencing and the results showed that melatonin increased the relative abundance of Actinobacteria compared with the control (p < 0.05) at the phylum level. However, Selenomonadales was markedly reduced compared with the control at the order level (p < 0.05). Gut and faecal volatile fatty acids were tested to evaluate the microbiota metabolism, but no difference was noticed in volatile fatty acid concentrations (p > 0.05). Melatonin improved intestinal development by affecting neural development, barrier integrity, nutrient absorption and microbiota in sucking piglets.

8.
Horm Behav ; 138: 105102, 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34998227

RESUMO

Not only males but also females compete over reproduction. In a population of free-living house mice (Mus musculus domesticus), we analyzed how (metabolic) costs of aggressive interactions (reflected in fresh wounds and long-term corticosterone concentrations in hair) are predicted by individual reproductive physiology and reproductive success in males and females. Over eight years, we studied wounds and reproduction of more than 2800 adults under naturally varying environmental conditions and analyzed steroid hormones from more than 1000 hair samples. Hair corticosterone were higher and wounds more frequent in males than females. In males, wound occurrence increased with increasing breeding activity in the population, without affecting hair corticosterone levels. Unexpectedly, individual male reproductive success did not predict wounds, while hair corticosterone increased with increasing levels of hair testosterone and reproductive success. High corticosterone in hair of males might therefore reflect metabolic costs of fighting over reproduction. In females, hair corticosterone was generally lower than in males and high levels did not impede pregnancy. Reproductive investment (reflected in hair progesterone) was dissociated from reproductive success. Occasional wounds in females indicated individuals without recent reproductive success and revealed reproductive competition, presumably driven by instability in the social environment. In both sexes, corticosterone increased with age, but there was no evidence that received overt aggression, as indicated by wounds or elevated corticosterone, suppressed reproductive physiology. Our results diverge from laboratory findings and emphasize the need to also study animals in their natural environment in order to understand the complexity of their behavioral physiology.

9.
Artigo em Inglês | MEDLINE | ID: mdl-35029827

RESUMO

MCM-48 molecular sieve with a large specific area (1470.87 m2/g) was hydrothermally synthesized for VOCs elimination by the adsorption method. The dynamic adsorption behaviors of toluene on this material were evaluated via breakthrough curves under both dry and wet conditions. A high toluene adsorption capacity of 171.13 mg/g was observed under dry conditions; however, in the presence of water vapor (20% RH), the adsorption capacity greatly decreased to 58.88 mg/g due to the competitive occupation of adsorption sites between water molecules and toluene molecules. To improve the affinity to toluene, functionalized MCM-48 materials were obtained by the co-condensation method and grafting method, respectively. It was found that co-M48(1:5)-100/48 sample by co-condensation method presents the highest dynamic adsorption capacity at both dry condition (194.62 mg/g) and 20% RH (122.42 mg/g), which has a significant advantage in the same type of adsorbent. This could be ascribed to the conjugated π-electrons effect between aromatic rings of phenyl groups uniformly distributed in MCM-48 skeleton and toluene molecules, which was qualitatively confirmed by FTIR. Moreover, cycle tests confirmed that this adsorbent possesses superior stability. The Yoon-Nelson model was successfully employed to describe the dynamic adsorption behavior of toluene over the organofunctionalized MCM-48 adsorbents, and the adsorption force of toluene was explained. Finally, a diagram describing the effect of different functionalization methods on the hydrophobicity and organophilicity of MCM-48 was given for a better understanding.

10.
ACS Appl Mater Interfaces ; 14(1): 1874-1884, 2022 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-34937333

RESUMO

A flexible strain sensor is of significant importance in wearable electronics since it can help monitor the physical signals from the human body. Among various strain sensors, the polyurethane (PU)-based ones have received widespread attention owing to their excellent toughness, large working range, and nice gas permeability. However, the hydrophobicity of these sensors is not good enough, which may affect their use life and sensitivity. In this work, a high-performance strain sensor composed of PU, reduced graphene oxide (rGO), polydopamine (PDA), and 1H,1H,2H,2H-perfluorodecane-thiol (PFDT) was designed and prepared. The results revealed that this PU/rGO/PDA/PFDT device possessed good superhydrophobicity with a water contact angle of 153.3°, a wide working strain range of 590%, and an outstanding gauge factor as high as 221 simultaneously. Because of these above advantages, the sensor worked effectively in detecting both subtle and large human movements (such as joint motion, finger motion, and vocal cord vibration) even in a high humidity environment. This strain sensor with high sensitivity, wide working range, and suitable modulus may have great potential in the field of flexible and wearable electronics in the near future.

11.
Cancer Lett ; 525: 9-21, 2022 01 28.
Artigo em Inglês | MEDLINE | ID: mdl-34715253

RESUMO

Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death among men in western countries. Androgen deprivation therapy (ADT) is considered the standard therapy for recurrent prostate cancer; however, this therapy may lead to ADT resistance and tumor progression, which seems to be regulated by epithelial-mesenchymal transition (EMT) and/or neuroendocrine differentiation (NED). In addition, recent data suggested the involvement of either adaptive or innate infiltrated immune cells in the initiation, progression, metastasis, and treatment of prostate cancer. In this review, we outlined the characteristics and roles of these immune cells in the initiation, progression, metastasis, and treatments of prostate cancer. We also summarized the current therapeutic strategies in targeting immune cells of the prostate tumor microenvironment.


Assuntos
Antagonistas de Androgênios/uso terapêutico , Androgênios/metabolismo , Neoplasias da Próstata/imunologia , Microambiente Tumoral/efeitos dos fármacos , Androgênios/imunologia , Progressão da Doença , Resistencia a Medicamentos Antineoplásicos/genética , Transição Epitelial-Mesenquimal/efeitos dos fármacos , Humanos , Masculino , Metástase Neoplásica , Próstata/metabolismo , Próstata/patologia , Neoplasias da Próstata/genética , Neoplasias da Próstata/patologia , Neoplasias da Próstata/terapia
12.
Food Chem ; 368: 130804, 2022 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-34404001

RESUMO

Herein, corn starch samples with different moisture contents (native corn starch, 30, 35, 40, 45, and 50%) were prepared by twin-screw extrusion, and the structural and physical properties were analyzed and correlated. Scanning electron microscopy observed the morphology, attenuated total reflection-Fourier transform infrared spectroscopy investigated the double helix structure, X-ray diffraction analyzed the crystal region, ion chromatography observed the chain length distribution, and rapid viscosity analyzer measured the viscosity of corn starch samples. We found that the corn starch crystallinity, degree of order, and double helix degree decreased with increasing moisture content. The moisture content has a crucial role in the peak viscosity, breakdown, final viscosity, and setback in pasting property experiments. With the increase in moisture content, the longer chain was transformed into a shorter chain, and the dispersion of molecular weight distribution continuously increased. This study provides a theoretical basis for the production of extruded corn starch.


Assuntos
Amido , Zea mays , Espectroscopia de Infravermelho com Transformada de Fourier , Viscosidade , Difração de Raios X
13.
Sci Total Environ ; 802: 149838, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34454156

RESUMO

Microplastics (MPs) have been widely detected in aquatic environments, and become emerging contaminants of growing concern. It is urgently needed to explore how to effectively remove MPs from water. This study first established an alternative method of removing MPs by magnetic nano-Fe3O4. Results showed that 1.3 g·L-1 nano-Fe3O4 and 150 min treatments caused optimal magnetization of MPs via surface absorption. Then, magnetized MPs in water can be conveniently removed by suction of the magnet. The average removal rate of four common types of MPs including polyethylene, polypropylene, polystyrene and polyethylene terephthalate in size of approximately 200-900 µm was 86.87 ± 6.92%, 85.05 ± 4.70%, 86.11 ± 6.21%, and 62.83 ± 8.34%, respectively. The removal rate varied among polymer- and size-different MPs, and was positively related to the density of nano-Fe3O4 absorbed on MP surfaces. In addition, the removal rate of MPs in artificial seawater was relatively high in comparison to pure water. Furthermore, the established approach was effectively applied to remove MPs in environmental water bodies including river water, domestic sewage, and natural seawater, with the removal rate of higher than 80%. Altogether, this study provided a novel and simple removal approach to remove MPs in water, which has a certain application prospect.


Assuntos
Microplásticos , Poluentes Químicos da Água , Monitoramento Ambiental , Fenômenos Magnéticos , Plásticos , Água , Poluentes Químicos da Água/análise
14.
Nanotechnology ; 33(13)2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34911057

RESUMO

Surface-enhanced Raman scattering (SERS) is recognized as one of the most favored techniques for enhancing Raman signals. The morphology of the SERS substrate profoundly affects molecular Raman spectra. This study aimed to construct a ring-mounted nanostructured substrate via liquid-liquid two-phase self-assembly incorporated with anodic aluminum oxide (AAO) membrane transfer techniques. High-density nanoparticles (NPs) assembled on AAO membranes were ascribed to reduce the diameters of the nanopores, with Au-Ag alloy NPs to regulate the dielectric constant so as to reveal the local surface plasmon resonance tunability. SERS engineered in this way allowed for the fabrication of a ring-mounted nanostructured substrate where the distribution density of NPs and dielectric constant could be independently fine-tuned. High SERS activity of the substrate was revealed by detecting the enhanced factor of crystal violet and rhodamine 6G molecules, which was up to 1.56 × 106. Moreover, SERS of thiram target molecules confirmed the supersensitivity and repeatability of the substrate as a practical application. The results of this study manifested a low-cost but high-efficiency ring-mounted nanostructured SERS substrate that might be suitable in many fields, including biosensing, medical research, environmental monitoring, and optoelectronics.

15.
Appl Microbiol Biotechnol ; 106(2): 855-863, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34921327

RESUMO

The outbreak of goose gout disease caused by novel goose astrovirus type 1 (GAstV-1) has resulted in huge economic losses to the goose industry in China since 2017. However, little is known about the B cell epitopes in major antigen of GAstV-1 and the serological approach for detection of GAstV-1 is not available. In this study, three novel monoclonal antibodies (mAbs) against the ORF2 protein were first generated and designated as 3G6, 5H7, and 6C6, respectively. Epitope mapping revealed that mAb 3G6, 5H7, and 6C6 recognized 695AVRFEKGGHE704, 685EKALSAPQAG694, and 635DDDPLSDVTS644 in ORF2, respectively. Sequence alignments found that the three epitopes were highly conserved in GAstV-1 but not in other AAstV members. Moreover, a mAb-based sandwich ELISA for the detection of GAstV-1 was first developed using mAb 6C6. The sandwich ELISA only reacted with GAstV-1 but not with GAstV-2 and the other goose-associated viruses tested. The limit of the detection of the sandwich ELISA reaches 1.58 × 103 TCID50/mL of GAstV-1. Notably, mAb 6C6 could also efficiently react with the GAstV-1 in tissue frozen sections of the clinical infected goose through IFA. The mAbs generated in this study pave the way for further studying on the role of ORF2 in the infection and pathogenesis of GAstV, and the sandwich ELISA and the tissue frozen section-IFA approaches established here provide efficient and rapid serological diagnostic tools for detection of GAstV-1. KEY POINTS: • Three novel B cell epitopes were identified in ORF2 of GAstV-1. • mAb-based ELISA and IFA for detection of GAstV-1 were developed.

16.
Food Chem ; 372: 131171, 2022 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-34601416

RESUMO

The genus Pleurotus, namely oyster mushroom, is widely cultivated and consumed worldwide. Cap color is an important commercial trait for oyster mushroom. Diverse color is determined by various pigment constituents. However, the pigments of oyster mushrooms are still ambiguous. In this study, we extracted and identified pigments of oyster mushroom species with black, yellow and pink cap color. The extracted pigments appearing the three color types correspondingly to the cap color, which were all identified as melanin using a panel of spectroscopic and physical/imaging techniques. Nevertheless, HPLC and elemental analysis indicated that the melanin in oyster mushrooms was actually a mixture of eumelanin and phaeomelanin. Differences in the quantities and relative proportions of eumelanin and phaeomelanin resulted in the color variation in oyster mushroom caps. Electron microscopy studies showed that the melanin units are likely located in the cell wall, as reported in other fungi. The pigments in oyster mushrooms with three different cap color were extracted and identified for the first time in this study, which provided fundamental knowledge for future studies on the mechanism of color formation in mushrooms.


Assuntos
Pleurotus , Parede Celular , Pigmentação , Pleurotus/genética , Análise Espectral
17.
Food Chem ; 372: 131211, 2022 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-34601423

RESUMO

In this study, the interaction of ovalbumin with lutein dipalmitate and the effect of ovalbumin on marigold lutein esters extracts were investigated. Lutein dipalmitate quenched the fluorescence of ovalbumin by static quenching. Binding and thermodynamic parameters proved that lutein dipalmitate bound to ovalbumin spontaneously by van der Waals force and hydrogen bond, and the complex stoichiometry was 1:1. Through three-dimensional fluorescence spectroscopy, Fourier transform infrared spectroscopy and circular dichroism experiments, the conformation of ovalbumin was unfolded, and alteration in the ovalbumin secondary structure induced by lutein dipalmitate was observed. The results of transmission electron microscopy and particle size revealed that there were spherical and nano-sized aggregates in the ovalbumin-lutein dipalmitate system, indicating the lutein dipalmitate not only could bind to ovalbumin at molecular level, but also promote the aggregation of ovalbumin. Additionally, the addition of ovalbumin had a positive effect on the stability of marigold lutein esters extracts.


Assuntos
Calendula , Luteína , Dicroísmo Circular , Ésteres , Ovalbumina , Extratos Vegetais , Espectrometria de Fluorescência , Espectroscopia de Infravermelho com Transformada de Fourier , Termodinâmica
18.
J Clin Lab Anal ; 36(1): e24153, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34918391

RESUMO

BACKGROUND: JNK pathway-associated phosphatase (JKAP) involves in the regulation of inflammation, immunity, and lung injury. The current study aimed to investigate correlation of JKAP with Th1, Th17 cells, acute exacerbation risk, and disease severity in chronic obstructive pulmonary disease (COPD) patients. METHODS: Totally, 45 stable COPD (SCOPD) patients, 45 acute exacerbation COPD (AECOPD) patients, and 45 controls were enrolled. Serum was collected for JKAP, interferon-gamma (IFN-γ) (Th1 cytokine), and interleukin 17 (IL-17) (Th17 cytokine) detection. Besides, peripheral blood mononuclear cell from COPD patients was collected for evaluating Th1 and Th17 cells. RESULTS: JKAP was highest in controls followed by SCOPD patients and lowest in AECOPD patients (median: 105.673 vs. 75.374 vs. 41.807 pg/ml, p < 0.001). Meanwhile, receiver operating characteristic (ROC) curves revealed that JKAP differentiated the AECOPD patients from the controls (area under curve (AUC): 0.910 (95% confidence interval (CI): 0.849-0.970)) and AECOPD patients from SCOPD patients (AUC: 0.726 (95% CI: 0.622-0.830)). Moreover, JKAP positively correlated with FEV1 (%predicted) in AECOPD patients (r = 0.347 p = 0.019). Additionally, JKAP was negatively correlated with the GOLD stage in AECOPD patients (r = -0.344, p = 0.021) and SCOPD patients (r = -0.357, p = 0.016). Whereas, JKAP was not associated with other clinical features (all p > 0.05). Besides, JKAP was negatively linked with Th17 cells (r = -0.378, p = 0.010), IFN-γ (r = -0.358, p = 0.016), IL-17 (r = -0.414, p = 0.005) in AECOPD patients and Th17 cells (r = -0.342, p = 0.022), IL-17 (r = -0.299, p = 0.046) in SCOPD patients. CONCLUSION: Downregulated JKAP correlates with Th17 cells, higher acute exacerbation risk, and severity in COPD patients, indicating its underlying potency as a biomarker for COPD.

19.
Environ Pollut ; 292(Pt B): 118465, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34748889

RESUMO

Indoor airborne microplastics fibers (MPFs) are emerging contaminants of growing concern. Nowadays, air conditioners (ACs) are widely used in indoor environments. However, little is known about their impact on the distribution of indoor MPFs. In this study, we first disclosed the prevalence of MPF contamination in filters for indoor split ACs used in living rooms, dormitories, and offices. The average density of microfibers was 1.47-21.4 × 102 items/cm2, and a total 27.7-35.0% of fibers were MPFs. Of these fibers, the majority were polyester (45.3%), rayon (27.8%), and cellophane (20.1%). We further tracked the long-term accumulation of MPFs on AC filters in three types of rooms, and demonstrated that dormitories showed relatively heavy accumulation especially after running for 35-42 days. Furthermore, we found that simulative AC filters which had been lined with PET MPFs could effectively release those MPFs into indoor air, propelling them away from the ACs at varying distances. Statistical analysis showed that the estimated daily intake of MPFs (5-5000 µm length) from AC filters would increase gradually with their usage, with the intake volume reaching up to 11.2 ± 2.2-44.0 ± 8.9 items/kg-BW/day by the 70th day, although this number varied among people of different ages. Altogether, these findings suggest that AC filters can act as both a sink and a source of microplastics fibers. Therefore, AC filters should be evaluated not only for their substantial impact on the distribution of indoor airborne MPFs, but also for their role in the prevalence of the related health risks.


Assuntos
Filtros de Ar , Poluição do Ar em Ambientes Fechados , Poluição do Ar em Ambientes Fechados/análise , Monitoramento Ambiental , Humanos , Microplásticos , Plásticos
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