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1.
J Hazard Mater ; 382: 121097, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31476722

RESUMO

Motivated by the use of ultraviolet (UV) radiation in the disinfection processes of drinking and waste water treatment plants, this study explores the colloidal properties and stability of UV irradiated graphene oxide (GO) by using the batch technique and time-resolved dynamic light scattering over a wide range of salt types (NaCl, MgCl2, and CaCl2) and ionic strength relevant to engineered and natural systems. The results show that the UV irradiation time has an important impact on the physicochemical properties of GO and consequently on its colloidal properties and stability. The aggregation kinetics, attachment efficiency and critical coagulation concentration (CCC) values of UV irradiated GO are obtained for the first time. By correlating CCC values with physicochemical properties, we find that the disorder degree plays a more important role in colloidal properties and stability of UV irradiated GO than oxygen containing functional groups. The findings are valuable for environmental fate assessments on various families of functionalized GO.

2.
Parasitol Int ; 74: 101925, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31077806

RESUMO

Tick-borne diseases cause significant losses to livestock production in tropical and subtropical regions. However, information about the tick-borne infections in cattle in Xinjiang Uygur Autonomous Region (XUAR), northwestern China, is scarce. In this study, nested polymerase chain reaction (PCR) assays and gene sequencing were used to detect and analyze epidemiological features of Babesia bovis, B. bigemina, Coxiella burnetii and Anaplasma bovis infections in XUAR. Out of 195 samples tested, 24 (12.3%), 67 (34.4%), 40 (20.5%) and 10 (5.1%) were positive for B. bovis, B. bigemina, C. burnetii and A. bovis, respectively. Sequencing analysis indicated that B. bovis SBP-4, B. bigemina Rap1a, C. burnetii htpB and A. bovis 16S rRNA genes from XUAR showed 99%-100% identity with documented isolates from other countries. Phylogenetic analyses revealed that B. bovis SBP-4, B. bigemina Rap1a, C. burnetii htpB and A. bovis 16S rRNA gene sequences clustered in the same clade with isolates from other countries. To the best of our knowledge, this is the first report of C. burnetii infection of cattle in XUAR. Furthermore, this study provides important data for understanding the distribution of tick-borne pathogens, and is expected to improve the approach for prevention and control of tick-borne diseases in China.

3.
Nanotechnology ; 31(5): 055705, 2020 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-31618712

RESUMO

Cu-supported nitrogen-doped carbon nanofibers (NCNFs) were fabricated via electrospinning and subsequent activation treatment with poly vinylpyrrolidone as both carbon and nitrogen sources. The NCNFs are firmly adhered to Cu foil without any additional binder and form a hierarchical three-dimensional net structure, which could effectively shorten the diffusion paths for electrons and lithium ions, thus resulting in lower impedance and superior electrochemical properties. Additionally, NCNFs feature a amorphous carbon structure, N-rich carbon lattice and wide pore distribution, not only ensuring fast ions/electrons transport, but also giving rise to the higher energy density. When directly used as a binder-free electrode, NCNFs deliver a high reversible capacity of 617.8 mAh g-1 at 200 mA g-1 after 100 cycles and maintain a superior capacity of 274.1 mAh g-1 at 1.44 A g-1 even after 500 cycles. Besides, the reversible capacity up to 216.5 mAh g-1 can be still obtained at a high current density of 6 A g-1, demonstrating the excellent high-rate cyclability. The facile synthesis approach and superior electrochemical properties make NCNFs electrodes an alternative anode candidate for lithium-ion batteries.

4.
Opt Lett ; 44(21): 5186-5189, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31674963

RESUMO

An optical diffractive neural network (DNN) can be implemented with a cascaded phase mask architecture. Like an optical computer, the system can perform machine learning tasks such as number digit recognition in an all-optical manner. However, the system can work only under coherent light illumination, and the precision requirement in practical experiments is quite high. This Letter proposes an optical machine learning framework based on single-pixel imaging (MLSPI). The MLSPI system can perform the same linear pattern recognition task as DNN. Furthermore, it can work under incoherent lighting conditions, has lower experimental complexity, and can be easily programmable.

5.
Medicine (Baltimore) ; 98(45): e17946, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31702684

RESUMO

BACKGROUND: Adaptive balance control is often compromised in children with developmental coordination disorder (DCD). Neuromuscular training (NMT) is commonly used in clinical settings to improve neuromuscular control and hence balance performance in these children. However, its effectiveness has not been proven scientifically. This randomized controlled study aimed to explore the effectiveness of NMT for improving adaptive balance performance and the associated leg muscle activation times in children with DCD. METHODS: Eighty-eight children with DCD were randomly assigned to the NMT or control group (44 per group). The NMT group received two 40-minute NMT sessions/week for 3 months, whereas the control group received no intervention. The outcomes were measured at baseline and 3 and 6 months. The primary outcome was the sway energy score (SES) in both the toes-up and toes-down conditions as derived using the Adaptation Test (ADT). Secondary outcomes included the medial gastrocnemius, medial hamstring, tibialis anterior and rectus femoris muscle activation onset latencies during ADT, measured using surface electromyography and accelerometry. Data were analyzed using a repeated measures analysis of covariance based on the intention-to-treat principle. RESULTS: At 3 months, no significant within-group or between-group differences were noted in the SESs for either group. At 6 months, the toes-down SES decreased by 6.8% compared to the baseline value in exclusively the NMT group (P = .004). No significant time, group or group-by-time interaction effects were observed in any leg muscle activation outcomes. CONCLUSIONS: Short-term NMT failed to improve adaptive balance performance and leg muscle activation times in children with DCD. Further studies should explore the clinical applications of longer-term task-specific interventions intended to improve the adaptive balance performance of these children.


Assuntos
Terapia por Exercício/métodos , Transtornos das Habilidades Motoras/reabilitação , Equilíbrio Postural , Adaptação Fisiológica , Criança , Eletromiografia , Feminino , Humanos , Masculino , Método Simples-Cego , Resultado do Tratamento
6.
J Interv Cardiol ; 2019: 6762089, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31772542

RESUMO

Introduction: Although coronary artery disease (CAD) presentations and clinical outcomes differ by sex, little is known about premature CAD (PCAD). The present analysis aimed to evaluate the gender-related differences of PCAD in an Asian population from the FOCUS registry. Methods: A total of 1397 Asian young patients with angiographically confirmed CAD undergoing drug-eluting stent implantation were included in this analysis and divided into two groups according to the genders. Patients were followed up for three years and clinical outcomes were compared between groups. Results: Young women were older and more likely to have hypertension and diabetes than men (all p<0.001). In contrast, males with PCAD had higher BMI and higher prevalence of current smoking as well as previous vessel revascularizations (all p<0.05). Men were more likely to be manifested as total occlusive lesions (p<0.001). Regardless of the clinical characteristics, the cumulative incidences of adverse events such as major adverse cardiovascular event (MACE), cardiovascular death, and all-cause death were not significantly different at one- or three-year follow-up (all p>0.05). Conclusion: Despite remarkable differences in clinical characteristics between Asian males and females with PCAD, the two groups did not differ significantly in clinical outcomes.

7.
Mol Ther Nucleic Acids ; 18: 787-800, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31734559

RESUMO

Exosomes, carriers to transfer endogenous molecules, derived from bone marrow-derived mesenchymal stem cells (BMSCs) have been reported to play a role in the progression of bladder cancer. Here we aimed to test the functional mechanism of microRNA-9-3p (miR-9-3p)-containing exosomes derived from BMSCs in bladder cancer. BMSCs were cocultured with bladder cancer cells, and exosomes secreted from BMSCs were identified. Next, the expression of miR-9-3p and endothelial cell-specific molecule 1 (ESM1) in bladder cancer tissues and cells was determined. Then effects of miR-9-3p and ESM1 via BMSC-derived exosomes on bladder cancer cell viability, migration, invasion, and apoptosis were determined by loss- and gain-of-function experiments and on in vivo tumor growth, and metastasis was assessed in nude mice. miR-9-3p expression was decreased and ESM1 was increased in bladder cancer. BMSCs inhibited bladder cancer cell viability, migration, and invasion, and induced apoptosis, whereas the addition of exosome secretion inhibitor GW4869 achieved the opposite effects. Moreover, exosomal miR-9-3p upregulation or ESM1 silencing suppressed bladder cancer cell viability, migration, and invasion; induced cell apoptosis; and inhibited in vivo tumor growth and metastasis. Taken together, BMSC-derived exosomal miR-9-3p suppressed the progression of bladder cancer through ESM1 downregulation, offering a potential novel therapeutic target for bladder cancer therapy.

8.
Dalton Trans ; 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31750479

RESUMO

Magnesium-lithium hybrid batteries (MLHBs) are playing an increasingly important role in energy storage systems owing to their abundant raw materials and favorable safety characteristics. Consequently, MLi2Ti6O14 (M = Sr, Ba, and Pb) compounds have been synthesized via a sol-gel method, followed by calcination. For the first time, as cathodes for MLHBs, MLi2Ti6O14 (M = Sr, Ba, and Pb) showed good electrochemical properties. For example, at 50 mA g-1, the specific capacities of MLi2Ti6O14 (M = Sr, Ba, and Pb) after 300 cycles are 75.6, 68.2 and 76.3 mA h g-1, respectively. In addition, MLi2Ti6O14 (M = Sr, Ba, and Pb) also possess outstanding rate performances. Importantly, the ion storage mechanism of MLi2Ti6O14 (M = Sr, Ba, and Pb) compounds in MLHBs was studied with PbLi2Ti6O14 as the representative. These results reveal that MLi2Ti6O14 (M = Sr, Ba, and Pb) have good electrochemical reversibility, and can be used as cathodes for MLHBs.

9.
Sci Rep ; 9(1): 17270, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31754166

RESUMO

It is generally acknowledged that the activation method and component of the precursor are of great importance for making porous carbon. In this study, four plant materials belong to one genus were selected as optimized plant material to produce hierarchical porous carbon for supercapacitors, the influence of initial structure was discussed. All the produced porous carbons have large specific surface area (higher than 2342 m2 g-1), high microporosity (more than 57%), and high pore volume (larger than 1.32 cm3 g-1). All the samples show characteristic of electrical double layer capacitance, and the onion-based porous carbon obtain highest specific capacitance of 568 F g-1 at the current density of 0.1 A g-1. With the current density rising from 1 A g-1 to 50 A g-1, the specific capacitance only decreases for 20%. After 5000 cycles, all the samples show relatively high capacitance retention (up to 97%). Two-step acid pickling has washed most impurities and directly lead to small equivalent series resistance (lower than 0.2 Ω). The samples show high power density and energy density (71 W h kg-1@180 W kg-1, 210 kW kg-1@33 W h kg-1). This study open an avenue to create high-performance hierarchical porous carbon based on plant architecture.

10.
Inorg Chem ; 2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31713423

RESUMO

Thermodynamic properties of the complexation of 2,2'-(trifluoroazanediyl)bis(N,N'-dimethylacetamide) (CF3ABDMA) with U(VI), Nd(III), and Np(V) have been studied in 1.0 M NaNO3 at 25 °C. Equilibrium constants of the complexation were determined by potentiometry and spectrophotometry. In comparison with a series of structurally related amine-bridged diacetamide ligands, including 2,2'-(benzylazanediyl)bis(N,N'-dimethylacetamide) (BnABDMA), 2,2'-azanediylbis(N,N'-dimethylacetamide) (ABDMA), and 2,2'-(methylazanediyl)bis(N,N'-dimethylacetamide) (MABDMA), CF3ABDMA forms weaker complexes with U(VI), Nd(III), and Np(V) due to the lower basicity of the center N atom in CF3ABDMA resulting from the attachment of the strong electron-withdrawing CF3- moiety. The complexation strength of CF3ABDMA with the three metal ions follows the order: UO22+ > Nd3+ > NpO2+, consistent with the order of the "effective" charges of the metal ions. Structural information on the U(VI)/CF3ABDMA complexes in solution and in solid was obtained by theoretical computation, single crystal X-ray diffractometry, 19F NMR, and electrospray ionization mass spectrometry. The structural data indicate that, similar to the three previously studied amine-bridged diacetamide ligands (BnABDMA, ABDMA, and MABDMA), the CF3ABDMA ligand coordinates to UO22+ in a tridentate mode, through the center nitrogen and the two amide oxygen atoms.

11.
Artigo em Inglês | MEDLINE | ID: mdl-31702129

RESUMO

Carbon-based electrocatalysts with single-metal-site hold great potential for the mechanism exploration via mimicking molecular catalysts, due to their distinct catalytic sites. In addition to metal atoms, the neighboring non-metal heteroatoms such as N, S, and O atoms, which are widely detected in carbon-based single-atom catalysts, may also contribute to enhancing the electrochemical activity of single-metal center. In this work, the boosting effect of O-doping toward electrochemical oxygen reduction reaction (ORR) was evaluated by both experimental study and DFT calculations. O-doped carbon supported single-Fe-site catalysts possessing deep mesopores and desirable hydrophilic surface were achieved by confined carbonization in inert or reductive atmosphere (SAFe-NDC and SAFe-NDC-H). As compared to the-state-of-the-art Pt/C, these catalysts showed superior catalytic activity toward ORR in terms of half-wave potential, Tafel slope as well as long-term stability. Particularly, SAFe-NDC-H outperformed the SAFe-NDC counterpart. Considering these two catalysts possess comparable porous structure, surface properties, and local electronic structure of single-Fe-site, the dopant non-metal O atoms, specifically, carbonyl group (C=O), are revealed to affect the ORR activity of single-Fe-site exclusively. The introduced C=O facilitates the formation of *OOH as well as the reduction of *OH, thereby reducing the catalysts' overpotential.

12.
CNS Neurosci Ther ; 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31730272

RESUMO

OBJECTIVE: Impairment of basal ganglia (BG)-thalamo-cortical circuit causes various symptoms of Parkinson's disease (PD). We investigated the functional connectivity (FC) patterns of putamen among PD subtypes and healthy control (HC) and explored their clinical significance. METHODS: A total of 16 patients with tremor-dominant (TD) PD, 23 patients with postural instability and gait difficulty-dominant (PIGD) PD, and 31 HC that underwent functional magnetic resonance imaging were observed. Voxel-wise FC analysis was performed by computing correlation between bilateral putamen and other voxels within the brain. Correlation analysis was performed between FC strength and clinical symptoms. RESULTS: Compared with PIGD group, TD group showed increased FC between left putamen and right cerebellum lobule VI and cerebellum crus I, then we compared the cerebellum FC difference among the three groups. The cerebellum lobule VI FC difference was mainly involved in motor related cortex, and the cerebellum crus I FC difference was related to cognition areas. While compared with HC, TD and PIGD groups both had significant FC difference brain areas correlated with motor and cognition symptoms. The connectively of putamen and right cerebellum lobules VI and I showed positive correlation with tremor and Montreal Cognitive Assessment degree of scores, respectively. The connectivity of putamen and sensorimotor cortex had negative correlation with PIGD scores. CONCLUSIONS: The altered connectivity of BG-cortical circuit in patients with PD was related to PIGD symptoms. Motor and cognitive impairments declined slower in patients with TD PD, which may be related to increased functional connectivity between putamen and cerebellum.

13.
Proc Natl Acad Sci U S A ; 116(47): 23404-23409, 2019 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-31685626

RESUMO

Phase transitions in halide perovskites triggered by external stimuli generate significantly different material properties, providing a great opportunity for broad applications. Here, we demonstrate an In-based, charge-ordered (In+/In3+) inorganic halide perovskite with the composition of Cs2In(I)In(III)Cl6 in which a pressure-driven semiconductor-to-metal phase transition exists. The single crystals, synthesized via a solid-state reaction method, crystallize in a distorted perovskite structure with space group I4/m with a = 17.2604(12) Å, c = 11.0113(16) Å if both the strong reflections and superstructures are considered. The supercell was further confirmed by rotation electron diffraction measurement. The pressure-induced semiconductor-to-metal phase transition was demonstrated by high-pressure Raman and absorbance spectroscopies and was consistent with theoretical modeling. This type of charge-ordered inorganic halide perovskite with a pressure-induced semiconductor-to-metal phase transition may inspire a range of potential applications.

14.
Int J Biol Sci ; 15(12): 2733-2749, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31754343

RESUMO

Breast cancer is one of the most common malignant tumors worldwide. Metastasis remains the leading cause of death in breast cancer patients. Research on the mechanism of breast cancer metastasis has become a core issue in breast cancer research. Our previous series of studies have shown that VASP, as a key oncogene, plays an important role in the development of various tumors such as breast cancer. In this study, we find that miR-638 can target to inhibit VASP expression, and Lin28 acts as an RNA-binding protein to regulate the processing of miR-638, which inhibits its maturation and promotes the expression of VASP. In addition, we also find that CREB1 acts as a transcription factor that binds to the promoter of Lin28 gene and activates the Lin28/miR-638/VASP pathway. Furthermore, CREB1 can also directly bind to the promoter of VASP, and activate VASP expression, forming a CREB/Lin28/miR-638/VASP interactive network, which plays an important role in promoting cell proliferation and migration in breast cancer. Our study explained the mechanism of CREB1/Lin28/miR-638/VASP network promoting the development of breast cancer, which further elucidated the mechanism of VASP as a key oncogene, and also provided a theoretical basis for expanding new approaches to tumor biotherapy.

15.
Parasitol Int ; : 102028, 2019 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-31759172

RESUMO

Q fever, spotted fever rickettsioses and equine piroplasmosis, are some of the most serious equine tick-borne diseases caused by Coxiella burnetii, Rickettsia spp., Babesia caballi and/or Theileria equi. This study surveyed and molecularly characterized these pathogens infecting horses in ten ranches from XUAR, China using molecular technology. Among 200 horse blood samples, 163 (81.5%) were infected with at least one of the pathogens. Rickettsia spp. was the most prevalent pathogen (n = 114, 57.0%), followed by C. burnetii (n = 79, 39.5%), T. equi (n = 79, 39.5%) and B. caballi (n = 49, 24.5%). Co-infections were observed in 61.3% of positive samples in this study. Statistically significant differences were observed between the sampling regions for C. burnetii, B. caballi and T. equi, and also in different age group for C. burnetii and T. equi. The genotype analysis indicated that C. burnetii htpB, Rickettsia spp. ompA, B. caballi rap-1, B. caballi 18S rRNA, T. equi EMA-1 and T. equi 18S rRNA gene sequences from horses in XUAR were variable. To the best of our knowledge, this study is the first report of C. burnetii and Rickettsia spp. infection and co-infected with piroplasma in horses in China. Overall, this study revealed the high infection rate of the pathogens in horses in XUAR, China. The current findings are expected to provide a basis for better tick-borne disease control in the region.

16.
Sci Total Environ ; 688: 1069-1080, 2019 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-31726538

RESUMO

Belowground interspecific facilitation and complementarity contribute to the phosphorus (P) uptake advantages in the cereal-legume intercropping system. However, the root morphological and physiological plasticity and, subsequently, the P uptake capability response to light conditions in intercropping systems remain unclear. Soybean was grown under two levels of P application rates in sole and intercropping systems (maize/soybean relay strip intercropping) from 2016 to 2018 in Renshou, southwest of China. As a supplement to the field experiment, soybean was also grown in L-S (simulating the light conditions of sole cropping in the field: light first and then shading) and S-L (simulating the light conditions of intercropping in the field: shading first and then light) light conditions with two levels of P application in 2018 in a pot experiment. After maize harvest (approximately 3/4 of the soybean growth period), light capture in intercropping was higher than sole (ameliorated light conditions in intercropping system), which resulted in an advantage of P uptake in intercropped soybean. Both low P supply and more light capture increased the total root length and root APase activity. The genes GmEXPB2 (which is associated with root growth) and GmACP1 (which is associated with exudation of APase) were highly expressed in plants that captured more light under both P-sufficient and P-deficient conditions. Additionally, more light capture increased the production of lateral roots and the proportion of in the upper 15 cm soil layer roots at the reproductive stage in the field. Across the field and pot experiments, increased root morphological and physiological plasticity were associated with lower P concentrations in the leaves and greater allocation of photosynthates to roots as sucrose. It is suggested that ameliorated light conditions can regulate soybean root growth plasticity and, consequently, P uptake in maize/soybean relay strip intercropping systems, especially in the areas with low solar radiation.

17.
Breast Cancer ; 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31728872

RESUMO

BACKGROUND: Breast cancer has become a dangerous killer for the female, which seriously threatened women's life, leading to huge pressures to society. The present study assessed the mechanism underlying the involvement of bone marrow tyrosine kinase on chromosome X (BMX) in breast cancer development. METHODS: The expression of BMX was examined by qPCR and immunohistochemistry. The effect of BMX on cell proliferation and migration was detected by Clone formation assay and Transwell assay. In vitro study, the correlation of BMX with Wnt/ß-catenin pathway was explored by western blot and TOP/FOP flash assay. RESULTS: In the present study, we found that BMX was up-regulated in breast cancer, which was associated with the tumor differentiation and TNM stage. Oncogenic BMX enhanced the ability of breast cancer cell proliferation and migration. Furthermore, BMX could up-regulate the protein expression levels of p-ß-catenin (Y142), p-ß-catenin(Y654) and inhibit the expression level of p-ß-catenin (S33/37), thus activating Wnt/ß-catenin pathway in MCF-7 and MDA-MB-231 cells. In addition, we revealed that BMX promoted GSK3ß phosphorylation, which suppressed the degradation of ß-catenin. CONCLUSIONS: In this study, we identified that BMX-activated Wnt/ß-catenin signaling pathway, playing an oncogenic role in breast cancer, suggesting that BMX could become a potential treatment target of breast cancer.

18.
Opt Express ; 27(20): 28194-28203, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31684576

RESUMO

We present the photonic spin Hall effect on an ellipsoidal Rayleigh particle, which amounts to a polarization-dependent shift in scattering far-field. Based on the dipole model, we demonstrate that such shift is unavoidable when the light incidence is inclined with respect to the main axis of the ellipsoidal Rayleigh particle. The result has general validity and can be applied to metal and dielectric materials. In addition, the photonic spin Hall effect also manifests itself in the optical force and torque exerted on the particle, which is promising for precision metrology, spin-optics devices and optical driven micro-machines. Due to wide existence of the Rayleigh particles in nature, we believe that our findings might provide a useful toolset for investigating polarization-dependent scattering of particles.

19.
Int J Cardiol ; 2019 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-31685245

RESUMO

BACKGROUND: Obesity is often considered as a risk factor of cardiovascular events, but recent researches showed conflicting results regarding to the effect of body weight on prognosis of coronary artery disease (CAD). This study aimed to evaluate the relationship between body mass index (BMI) and clinical outcomes of CAD in Asian population. METHODS: A total of 4315 patients from the FOCUS registry were enrolled into this analysis. Patients were divided into 4 groups according to BMI: lean group (BMI<18.5 kg/m2), normal group (BMI 18.5-24.9 kg/m2), overweight group (BMI 25-30 kg/m2) and obesity group (BMI>30 kg/m2). Follow-up was continued to 3 years to evaluate clinical outcomes, and the primary endpoint was a composite of all-cause death and myocardial infarction (MI). RESULTS: Patients with higher BMI were more likely to be associated with cardiovascular risk factors like hypertension, hypercholesterolemia and diabetes, but not smoking. At the end of the follow-up period, however, the incidence of a composite endpoint of all-cause death and MI was significantly lower in the higher BMI (overweight and obese) subsets, as compared with the lower BMI group (5.2% vs. 8.0%, p < 0.001). So did the cumulative rates of all-cause death (p < 0.001), cardiovascular death (p < 0.001), and a combined endpoint of cardiovascular death and MI (p = 0.001). CONCLUSIONS: In Asian patients with CAD, an inverse association between BMI and long-term prognosis was observed. Although overweight or obese patients were associated with more metabolism-associated comorbidities, they had significantly lower adverse events at 3-year follow up after percutaneous coronary intervention.

20.
J Craniofac Surg ; 30(8): e697-e700, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31689737

RESUMO

OBJECTIVE: Accurate localization and removal of deep-seated cavernomas through a less invasive approach is still a challenge. The aim of this study is to compare the efficacy of neuronavigation and ultrasound in guiding surgery for resection of deep-seated cavernomas by transsulcal microsurgical approach. METHODS: A total of 38 consecutive patients who suffered from deep-seated cavernomas underwent surgery via a transsulcal microsurgical approach in our hospital between September 2016 and March 2018. Patients were randomly divided into 2 groups (20 cases in neuronavigation group and 18 cases in ultrasound group). The clinical features, character of images, and surgical outcome were analyzed. RESULTS: There was no significant difference between the 2 groups in diameter (16.6 ±â€Š2.7 mm versus 19.6 ±â€Š2.0 mm, P > 0.05) and depth (19.2 ±â€Š2.4 mm versus 22.0 ±â€Š4.6 mm, P > 0.05) of lesions. The ultrasound group had a similar tumor resection rate (100% versus 80%, P = 0.11) and shorter operation time (119.7 ±â€Š4.5 minutes versus 137.3 ±â€Š4.9 minutes, P < 0.05) than that in the neuronavigation group. There was no significant difference between in the symptomatic improvement rate, complication, postoperative hospital stay, and period of follow-up (P > 0.05). No death and recurrence appeared in both groups. CONCLUSION: Ultrasound showed certain advantages than neuronavigation in guiding resection of deep-seated cavernomas by transsulcal microsurgical approach.

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