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PeerJ ; 12: e17268, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38708351


Objective: To study the efficacy of PADTM Plus-based photoactivated disinfection (PAD) for treating denture stomatitis (DS) in diabetic rats by establishing a diabetic rat DS model. Methods: The diabetic rat DS model was developed by randomly selecting 2-month-old male Sprague-Dawley rats and dividing them into four groups. The palate and denture surfaces of rats in the PAD groups were incubated with 1 mg/mL toluidine blue O for 1 min each, followed by a 1-min exposure to 750-mW light-emitting diode light. The PAD-1 group received one radiation treatment, and the PAD-2 group received three radiation treatments over 5 days with a 1-day interval. The nystatin (NYS) group received treatment for 5 days with a suspension of NYS of 100,000 IU. The infection group did not receive any treatment. In each group, assessments included an inflammation score of the palate, tests for fungal load, histological evaluation, and immunohistochemical detection of interleukin-17 (IL-17) and tumor necrosis factor (TNF-α) conducted 1 and 7 days following the conclusion of treatment. Results: One day after treatment, the fungal load on the palate and dentures, as well as the mean optical density values of IL-17 and TNF-α, were found to be greater in the infection group than in the other three treatment groups (P < 0.05). On the 7th day after treatment, these values were significantly higher in the infection group than in the PAD-2 and NYS groups (P < 0.05). Importantly, there were no differences between the infection and PAD-1 groups nor between the PAD-2 and NYS groups (P > 0.05). Conclusions: PAD effectively reduced the fungal load and the expressions of IL-17 and TNF-α in the palate and denture of diabetic DS rats. The efficacy of multiple-light treatments was superior to that of single-light treatments and similar to that of NYS.

Diabetes Mellitus Experimental , Desinfecção , Ratos Sprague-Dawley , Estomatite sob Prótese , Animais , Masculino , Ratos , Estomatite sob Prótese/microbiologia , Estomatite sob Prótese/radioterapia , Estomatite sob Prótese/tratamento farmacológico , Desinfecção/métodos , Cloreto de Tolônio/farmacologia , Cloreto de Tolônio/uso terapêutico , Fator de Necrose Tumoral alfa/metabolismo , Interleucina-17/metabolismo , Modelos Animais de Doenças
PeerJ ; 11: e16633, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38111655


Leptin is a peptide hormone that regulates energy balance, immune inflammatory response, and bone metabolism. Several studies have demonstrated a relationship between leptin and periodontitis, a local inflammatory disease that progressively weakens the supporting structures of the teeth, eventually leading to tooth loss. This article reviews the existing literature and discusses leptin's basic characteristics, its relationship with periodontitis, and its effects on periodontal tissue metabolism.

Leptina , Periodontite , Humanos , Periodontite/complicações , Transdução de Sinais , Metabolismo Energético